{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:38:45Z","timestamp":1767911925146,"version":"3.49.0"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,1,1]]},"abstract":"<jats:p>Objectives.\u2003To identify the causative agents, presenting signs and symptoms, and course of disease in children diagnosed with anaphylaxis.<\/jats:p>\n               <jats:p>Design.\u2003Five-year retrospective chart review.<\/jats:p>\n               <jats:p>Setting.\u2003Urban children\u2019s hospital pediatric emergency department, operating suite, and inpatient units.<\/jats:p>\n               <jats:p>Participants.\u2003Fifty-five cases of anaphylaxis in 50 patients 1 to 19 years of age.<\/jats:p>\n               <jats:p>Interventions.\u2003None.<\/jats:p>\n               <jats:p>Results.\u2003The most common inciting agents in this population were latex (27%), food (25%), drugs (16%), and venoms (15%). Thirty-two cases (58%) occurred outside of the hospital, including 3 of 11 severe cases. Nineteen (35%) had histories of prior allergy to the causative agent. Most agent exposures were intravenous (38%), oral (27%), or dermal (20%). The most common systems involved were respiratory (93%), skin (93%), cardiovascular (26%), and neurologic (26%). Features distinguishing the 11 patients requiring intensive care included latex agents (45%), nonenteral route of exposure (91%), and presence of cardiovascular symptoms (45%). Of the 17 patients with known past anaphylaxis, only 5 had epinephrine self-administration devices available, and 3 had used them.<\/jats:p>\n               <jats:p>Conclusions.\u2003(1) Most patients with anaphylaxis present with skin or respiratory symptoms. (2) Severely ill children more commonly have nonenteral and\/or latex exposures that occur in the hospital. (3) Most children with anaphylaxis have no stated histories of prior reaction to the causative agent. (4) Those patients who have had past episodes of anaphylaxis infrequently have epinephrine self-administration devices available for use. anaphylaxis, allergy, latex.<\/jats:p>","DOI":"10.1542\/peds.99.1.e7","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T22:12:21Z","timestamp":1092435141000},"page":"e7-e7","source":"Crossref","is-referenced-by-count":83,"title":["Anaphylaxis in Children: A 5-Year Experience"],"prefix":"10.1542","volume":"99","author":[{"given":"Susan D.","family":"Dibs","sequence":"first","affiliation":[{"name":"1From the Division of Emergency Medicine, Children\u2019s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Douglas","family":"Baker","sequence":"additional","affiliation":[{"name":"1From the Division of Emergency Medicine, Children\u2019s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[1997,1,1]]},"reference":[{"key":"2022051611394044900_B1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1056\/NEJM199208063270603","article-title":"Fatal and near-fatal anaphylactic reactions to food in children and adolescents.","volume":"327","author":"Sampson","year":"1992","journal-title":"N Engl J Med."},{"key":"2022051611394044900_B2","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1001\/jama.1988.03410100140041","article-title":"Fatal food-induced anaphylaxis.","volume":"260","author":"Yunginger","year":"1988","journal-title":"JAMA"},{"key":"2022051611394044900_B3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1542\/peds.94.1.115","article-title":"Multiple Africanized bee stings in a child.","volume":"94","author":"Arive","year":"1994","journal-title":"Pediatrics."},{"key":"2022051611394044900_B4","first-page":"220","article-title":"Peanuts. Allergic and other untoward reactions.","volume":"48","author":"Fries","year":"1982","journal-title":"Ann Allergy."},{"key":"2022051611394044900_B5","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/0091-6749(91)90385-2","article-title":"Intraoperative anaphylaxis: an association with latex sensitivity.","volume":"87","author":"Gold","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"2022051611394044900_B6"},{"key":"2022051611394044900_B7"},{"key":"2022051611394044900_B8","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3928\/0090-4481-19920901-10","article-title":"Anaphylaxis in children.","volume":"21","author":"Saryan","year":"1992","journal-title":"Pediatr Ann."},{"key":"2022051611394044900_B9","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1056\/NEJM199106203242506","article-title":"Anaphylaxis.","volume":"324","author":"Bochner","year":"1991","journal-title":"N Engl J Med"},{"key":"2022051611394044900_B10","first-page":"87","article-title":"Anaphylaxis.","volume":"69","author":"Yunginger","year":"1992","journal-title":"Ann Allergy."},{"key":"2022051611394044900_B11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0025-7125(16)30328-5","article-title":"Anaphylaxis.","volume":"76","author":"Atkinson","year":"1992","journal-title":"Med Clin North Am."},{"key":"2022051611394044900_B12","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1001\/jama.1992.03490200082008","article-title":"Anaphylaxis and stinging insect hypersensitivity.","volume":"268","author":"Valentine","year":"1992","journal-title":"JAMA."},{"key":"2022051611394044900_B13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/00325481.1993.11701726","article-title":"Allergy to insect stings.","volume":"93","author":"Moffitt","year":"1993","journal-title":"Postgrad Med."},{"key":"2022051611394044900_B14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0091-6749(94)90071-X","article-title":"A cluster of anaphylactic reactions in children with spina bifida during general anesthesia: epidemiologic features, risk factors, and latex hypersensitivity.","volume":"94","author":"Kelly","year":"1994","journal-title":"J Allergy Clin Immunol."},{"key":"2022051611394044900_B15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0022-3476(96)70272-X","article-title":"Current perspectives on latex allergy.","volume":"128","author":"Landwehr","year":"1996","journal-title":"J Pediatr."},{"key":"2022051611394044900_B16","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1542\/peds.91.2.516","article-title":"Anaphylaxis at school: etiologic factors, prevalence and treatment.","volume":"91","author":"Wynn","year":"1993","journal-title":"Pediatrics."},{"key":"2022051611394044900_B17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1746-1561.1994.tb03274.x","article-title":"Preparing school personnel to assist students with life-threatening food allergies.","volume":"64","author":"Hay","year":"1994","journal-title":"J Sch Health."}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/99\/1\/e7\/985062\/pe017e00e71p.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/99\/1\/e7\/985062\/pe017e00e71p.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T11:40:02Z","timestamp":1652701202000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/99\/1\/e7\/75917\/Anaphylaxis-in-Children-A-5-Year-Experience"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1,1]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1997,1,1]]},"published-print":{"date-parts":[[1997,1,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.99.1.e7","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"value":"1098-4275","type":"electronic"},{"value":"0031-4005","type":"print"}],"subject":[],"published":{"date-parts":[[1997,1,1]]}}}