{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:15:20Z","timestamp":1787022920121,"version":"build-2736575974"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:p>Background.\u2003Respiratory syncytial virus (RSV) is the most important viral respiratory pathogen of infancy and childhood. Much has been written about inpatients with severe disease. Inpatients, however, represent only a minority of RSV-infected children. We studied the characteristics of symptomatic outpatient RSV infection in healthy children to gain a better understanding of RSV disease and to provide a background for the testing of intervention strategies in children without high-risk conditions.<\/jats:p>\n                  <jats:p>Methods.\u2003A total of 1113 children were followed during 20 consecutive RSV seasons. Signs and symptoms of respiratory infection were monitored. Cultures were obtained for febrile upper respiratory infection, acute otitis media, and lower respiratory infection (LRI). Rates of febrile upper respiratory infection, acute otitis media, LRI, and hospitalization were calculated. Given those rates, numbers of children needed to demonstrate efficacy of a vaccine product were calculated.<\/jats:p>\n                  <jats:p>Results.\u2003Mild disease from RSV infection lacked some of the classic features of RSV infection seen in hospitalized children. Involvement of the lower respiratory tract was, however, noted to be much higher in RSV infection than it was in infection with other viral respiratory pathogens. LRI was, therefore, considered the best candidate endpoint for vaccine trials. A product with 60% efficacy could be proven, with a power of 0.8, to be efficacious with as few as 1500 infants.<\/jats:p>\n                  <jats:p>Conclusions.\u2003RSV infection is common and often involves the lower respiratory tract, even in outpatients. Our 20-year study of RSV infection provides a basis for calculation of sample sizes to be used in trials of vaccine candidates. respiratory syncytial virus, outpatient, epidemiology, vaccine, bronchiolitis.<\/jats:p>","DOI":"10.1542\/peds.99.2.e7","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T19:40:17Z","timestamp":1092426017000},"page":"e7-e7","source":"Crossref","is-referenced-by-count":48,"title":["Twenty Years of Outpatient Respiratory Syncytial Virus Infection:  A Framework for Vaccine Efficacy Trials"],"prefix":"10.1542","volume":"99","author":[{"given":"Randall G.","family":"Fisher","sequence":"first","affiliation":[{"name":"From the Departments of Pediatric Infectious Diseases and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Gruber","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Infectious Diseases and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Edwards","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Infectious Diseases and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Reed","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Vanderbilt University Medical Center, Nashville, Tennessee."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon J.","family":"Tollefson","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Infectious Diseases and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Infectious Diseases and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Wright","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Infectious Diseases and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[1997,2,1]]},"reference":[{"key":"2021121006463714400_B1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1056\/NEJM197303082881005","article-title":"Epidemiology of acute lower respiratory diseases in children.","volume":"288","author":"Glezen","year":"1973","journal-title":"N Engl J Med."},{"key":"2021121006463714400_B2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/oxfordjournals.aje.a121565","article-title":"Epidemiology of respiratory syncytial virus infection in Washington, DC. 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