{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:08:31Z","timestamp":1789711711373,"version":"4.0.1"},"reference-count":14,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,3,1]]},"abstract":"<jats:p>Objectives.\u2003Coagulopathy is a potential complication of head trauma that may be attributable to parenchymal brain damage. The objectives of this study were to assess the frequency of coagulation defects in pediatric abusivehead trauma and to analyze their relationship to parenchymal brain damage.<\/jats:p>\n               <jats:p>Methods.\u2003We reviewed the records of 265 pediatric patients hospitalized for head trauma. One hundred forty-seven patients met study inclusion criteria: (1) radiologic evidence of head trauma, (2) multidisciplinary validation that head trauma had been inflicted, and (3) coagulation screening performed within 2 days of presentation. Using nonparametric analysis, initial coagulation test results were compared between study patients without parenchymal brain damage and those with parenchymal brain damage.<\/jats:p>\n               <jats:p>Results.\u2003Mild prothrombin time (PT) prolongations (median 13.1) occurred in 54% of study patients with parenchymal brain damage and only 20% of study patients withoutparenchymal brain damage. Among pediatric abusive head trauma patients with parenchymal brain damage who died, 94% displayed PT prolongations (median 16.3) and 63% manifested evidence of activated coagulation.<\/jats:p>\n               <jats:p>Conclusions.\u2003PT prolongation and activated coagulation are common complications of pediatric abusive head trauma. In the presence of parenchymal brain damage, it is highly unlikely that these coagulation abnormalities reflect a preexisting hemorrhagic diathesis. These conclusions have diagnostic, prognostic, and legal significance.<\/jats:p>","DOI":"10.1542\/peds.99.3.371","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:40:17Z","timestamp":1092440417000},"page":"371-375","source":"Crossref","is-referenced-by-count":115,"title":["Coagulopathy in Pediatric Abusive Head Trauma"],"prefix":"10.1542","volume":"99","author":[{"given":"Kent P.","family":"Hymel","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado; the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Abshire","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Luckey","sequence":"additional","affiliation":[{"name":"Prevention Research Center for Family and Child Health, University of Colorado Health Sciences Center, Denver, Colorado."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Jenny","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado; the"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[1997,3,1]]},"reference":[{"key":"2021120819221793900_B1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0022-3476(82)80565-9","article-title":"Disseminated intravascular coagulation fibrinolytic syndrome following head injury in children: frequency and prognostic implications.","volume":"100","author":"Miner","year":"1982","journal-title":"J Pediatr."},{"key":"2021120819221793900_B2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3171\/jns.1978.49.3.0357","article-title":"Head injury and coagulation disorders.","volume":"49","author":"Jaap van der Sandle","year":"1978","journal-title":"J Neurosurg."},{"key":"2021120819221793900_B3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1227\/00006123-198407000-00008","article-title":"Clinicopathological correlations of disseminated intravascular coagulation in patients with head injury.","volume":"15","author":"Kaufman","year":"1984","journal-title":"Neurosurgery."},{"key":"2021120819221793900_B4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1227\/00006123-198610000-00005","article-title":"Relationship between abnormalities of coagulation and fibrinolysis and postoperative intracranial hemorrhage in head injury.","volume":"19","author":"Touho","year":"1986","journal-title":"Neurosurgery."},{"key":"2021120819221793900_B5","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1227\/00006123-198906000-00007","article-title":"The incidence and significance of hemostatic abnormalities in patients with 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Med."},{"key":"2021120819221793900_B9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1227\/00006123-199202000-00002","article-title":"Delayed brain injury after head trauma: significance of coagulopathy.","volume":"30","author":"Stein","year":"1992","journal-title":"Neurosurgery."},{"key":"2021120819221793900_B10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1227\/00006123-198011000-00003","article-title":"Delayed and recurrent intracranial hematomas related to disseminated intravascular clotting and fibrinolysis in head injury.","volume":"7","author":"Kaufman","year":"1980","journal-title":"Neurosurgery."},{"key":"2021120819221793900_B11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0022-3476(85)80656-9","article-title":"Vitamin K in 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activation.","volume":"81","author":"Morrissey","year":"1993","journal-title":"Blood."}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/99\/3\/371\/998177\/pe039700371o.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/99\/3\/371\/998177\/pe039700371o.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T20:19:29Z","timestamp":1638994769000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/99\/3\/371\/67453\/Coagulopathy-in-Pediatric-Abusive-Head-Trauma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3,1]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1997,3,1]]},"published-print":{"date-parts":[[1997,3,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.99.3.371","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"value":"1098-4275","type":"electronic"},{"value":"0031-4005","type":"print"}],"subject":[],"published":{"date-parts":[[1997,3,1]]}}}