{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:33:23Z","timestamp":1772811203105,"version":"3.50.1"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,5,1]]},"abstract":"<jats:p>Objective.\u2003To evaluate the efficacy of fiber-optic phototherapy using the standard Ohmeda Biliblanket, a large version, double standard Biliblankets, and conventional phototherapy using daylight fluorescent lamps in full-term, healthy infants with nonhemolytic hyperbilirubinemia.<\/jats:p><jats:p>Methods.\u2003Full-term, healthy infants with nonhemolytic hyperbilirubinemia (bilirubin concentration, &amp;gt;255 \u03bcmol\/L or 222 \u03bcmol\/L at &amp;lt;48 hours of age) were allocated randomly to one of four modes of phototherapy: standard fiber-optic mat (Ohmeda Biliblanket), a large version, double standard Biliblankets, and conventional phototherapy. Bilirubin levels were monitored every 12 hours. Exposure was stopped when bilirubin levels were less than 185 \u03bcmol\/L, the minimum duration being 24 hours.<\/jats:p><jats:p>Results.\u2003A total of 171 infants were studied; 42 were exposed to standard fiber-optic phototherapy, 43 to large fiber-optic phototherapy, 42 to double\u2013fiber-optic phototherapy, and 44 to conventional phototherapy. Durations of exposure were 87.05 \u00b1 6.09 (SEM), 82.57 \u00b1 5.84, 64.85 \u00b1 5.43, and 62.61 \u00b1 3.74 hours, respectively; the 24-hour decline rates were 10.26% \u00b1 1.84%, 14.50% \u00b1 1.53%, 21.82% \u00b1 1.71%, and 19.00% \u00b1 1.65%, respectively; the overall decline rates over the whole exposure period were 0.47% \u00b1 0.03%, 0.52% \u00b1 0.04%, 0.71% \u00b1 0.05%, and 0.75% \u00b1 0.04% per hour, respectively. The efficacy of double\u2013fiber-optic phototherapy and conventional phototherapy was similar and significantly better than that of the large fiber-optic mat and the standard fiber-optic mat in duration, 24-hour decline rate, and overall decline rate. The large mat was slightly better than the standard-size mat with regard to 24-hour decline rate and overall decline rate, but this difference was not significant. Failure of phototherapy occurred only in the large fiber-optic mat group (3 of 43) and the standard fiber-optic mat group (4 of 42); none occurred in the other two groups, but differences not statistically significant. The nursing personnel were more comfortable with single fiber-optic phototherapy, which caused no initial disturbance to the swaddled infants as did conventional phototherapy, but found double\u2013fiber-optic phototherapy difficult to use.<\/jats:p><jats:p>Conclusion.\u2003For efficacy of fiber-optic phototherapy in full-term infants to be comparable to that of our conventional phototherapy, the light dose of the standard mats needs to be doubled. fiber-optic phototherapy, neonatal hyperbilirubinemia, efficacy.<\/jats:p>","DOI":"10.1542\/peds.99.5.e13","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:40:17Z","timestamp":1092440417000},"page":"e13-e13","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of Bidirectional Fiber-optic Phototherapy for Neonatal Hyperbilirubinemia"],"prefix":"10.1542","volume":"99","author":[{"given":"K. L.","family":"Tan","sequence":"first","affiliation":[{"name":"1 From the Department of Neonatology, National University Hospital, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[1997,5,1]]},"reference":[{"key":"2021121009521872700_B1","first-page":"243","article-title":"A new device for phototherapy treatment of jaundiced infants.","volume":"10","author":"Rosenfeld","year":"1990","journal-title":"J Perinatol."},{"key":"2021121009521872700_B2","first-page":"235","article-title":"A clinical trial of fiberoptic phototherapy vs conventional phototherapy.","volume":"146","author":"Holtrop","year":"1992","journal-title":"Am J Dis Child."},{"key":"2021121009521872700_B3","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1542\/peds.90.5.674","article-title":"Double versus single phototherapy in low birth weight infants.","volume":"90","author":"Holtrop","year":"1992","journal-title":"Pediatrics."},{"key":"2021121009521872700_B4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/000992289403300313","article-title":"Ohmeda Biliblanket vs Wallaby phototherapy system for the reduction of bilirubin levels in the home care setting.","volume":"33","author":"George","year":"1994","journal-title":"Clin Pediatr."},{"key":"2021121009521872700_B5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0022-3476(94)70019-2","article-title":"Comparison of the efficacy of fiberoptic and conventional phototherapy for neonatal hyperbilirubinemia.","volume":"125","author":"Tan","year":"1994","journal-title":"J Pediatr."},{"key":"2021121009521872700_B6","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1136\/bmj.293.6558.1361","article-title":"Efficacy of phototherapy on neonatal hyperbilirubinaemia.","volume":"293","author":"Tan","year":"1986","journal-title":"Br Med 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Pediatr."},{"key":"2021121009521872700_B10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0140-6736(95)91244-4","article-title":"1-day phototherapy of neonatal jaundice with blue-green lamp.","volume":"346","author":"Donzelli","year":"1996","journal-title":"Lancet."},{"key":"2021121009521872700_B11","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1651-2227.1992.tb12126.x","article-title":"Efficacy of high intensity blue light and standard daylight phototherapy for non-haemolytic hyperbilirubinaemia.","volume":"81","author":"Tan","year":"1992","journal-title":"Acta Paediatr."},{"key":"2021121009521872700_B12","first-page":"550","article-title":"Comparison of the effectiveness of single-direction and double-direction phototherapy for neonatal jaundice.","volume":"56","author":"Tan","year":"1975","journal-title":"Pediatrics."},{"key":"2021121009521872700_B13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0095-5108(18)30506-2","article-title":"Phototherapy for neonatal jaundice.","volume":"18","author":"Tan","year":"1991","journal-title":"Clin Perinatol."},{"key":"2021121009521872700_B14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0022-3476(74)80524-X","article-title":"Phototherapy of neonatal hyperbilirubinemia: bilirubin in unexposed areas of the skin.","volume":"85","author":"Vogl","year":"1974","journal-title":"J Pediatr."},{"key":"2021121009521872700_B15","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000243822","article-title":"Phototherapy for ABO haemolytic hyperbilirubinaemia.","volume":"61","author":"Tan","year":"1992","journal-title":"Biol 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