{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:13:36Z","timestamp":1788261216942,"version":"build-2803163510"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p>Helicobacter pylori causes one of the most common chronic bacterial infections. Clinical manifestations include asymptomatic chronic gastritis, gastric and duodenal ulcers, adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma in adults. In children, most H pylori infections are asymptomatic despite being associated with microscopic gastric inflammation, and children rarely develop complications associated with infection. Due to rising resistance and lack of symptomatic improvement in the absence of peptic ulcer disease, testing and eradication therapy are recommended only for the subset of patients in whom there is a high suspicion of peptic ulcer disease. Studies do not support the role of H pylori infection in functional disorders such as recurrent abdominal pain. A variety of diagnostic modalities exist; therefore, it is important to understand the appropriate approach to diagnosing H pylori infection. The joint European Society for Pediatric Gastroenterology, Hepatology, and Nutrition\/North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines were updated in 2016. Antibiotic and proton pump inhibitor weight-based dosing guidelines have changed to prevent ineffective treatment from increasing antimicrobial resistance. Treatment can also be guided by antibiotic sensitivities obtained from H pylori culture. Patients should be tested again after treatment to confirm eradication.<\/jats:p>","DOI":"10.1542\/pir.2019-0048","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T14:20:23Z","timestamp":1604326823000},"page":"585-592","source":"Crossref","is-referenced-by-count":16,"title":["<i>Helicobacter pylori<\/i>in Pediatric Patients"],"prefix":"10.1542","volume":"41","author":[{"given":"Yelena","family":"Korotkaya","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Johns Hopkins School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darla","family":"Shores","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Johns Hopkins School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2020,11,1]]},"reference":[{"key":"2022041520363061700_B1","article-title":"Helicobacter pylori infection","year":"2015"},{"key":"2022041520363061700_B2","doi-asserted-by":"crossref","DOI":"10.1001\/archpedi.159.5.415","article-title":"What is new related to Helicobacter pylori infection in children and teenagers?","author":"Kato S","year":"2005"},{"issue":"12)","key":"2022041520363061700_B3","first-page":"1","article-title":"New diagnostic strategies for detection of Helicobacter pylori infection in pediatric patients","volume":"10","author":"Gold","year":"2014","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"2022041520363061700_B4","author":"American Academy of Pediatrics","year":"2018"},{"key":"2022041520363061700_B5","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12165","article-title":"Epidemiology of Helicobacter pylori infection","author":"Eusebi LH","year":"2014"},{"key":"2022041520363061700_B6","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12414","volume-title":"Helicobacter pylori infection in children.","author":"Kalach","year":"2017"},{"key":"2022041520363061700_B7","doi-asserted-by":"crossref","DOI":"10.4137\/CGast.S13760","article-title":"Virulence factors of Helicobacter pylori: a review","author":"Roesler","year":"2014"},{"issue":"8","key":"2022041520363061700_B8","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/gutjnl-2014-307689","article-title":"Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city","volume":"64","author":"den Hollander","year":"2015","journal-title":"Gut"},{"key":"2022041520363061700_B9","year":"2016"},{"issue":"6","key":"2022041520363061700_B10","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/MPG.0000000000001594","article-title":"Joint ESPGHAN\/NASPGHAN guidelines for the management of Helicobacter pylori in children and adolescents (update 2016)","volume":"64","author":"Jones","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"2022041520363061700_B11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.gie.2006.03.015","article-title":"Complications of pediatric EGD: a 4-year experience in PEDS-CORI","volume":"65","author":"Thakkar","year":"2007","journal-title":"Gastrointest Endosc"},{"issue":"7","key":"2022041520363061700_B12","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1365-2036.2008.03807.x","article-title":"Meta-analysis: high-dose proton pump inhibitors vs. standard dose in triple therapy for Helicobacter pylori eradication","volume":"28","author":"Villoria","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"2022041520363061700_B13","year":"2017"}],"container-title":["Pediatrics In Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatricsinreview\/article-pdf\/41\/11\/585\/1279211\/pedsinreview_20190048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatricsinreview\/article-pdf\/41\/11\/585\/1279211\/pedsinreview_20190048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T10:06:21Z","timestamp":1698314781000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatricsinreview\/article\/41\/11\/585\/35348\/Helicobacter-pylori-in-Pediatric-Patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":13,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,1]]},"published-print":{"date-parts":[[2020,11,1]]}},"URL":"https:\/\/doi.org\/10.1542\/pir.2019-0048","relation":{},"ISSN":["0191-9601","1526-3347"],"issn-type":[{"value":"0191-9601","type":"print"},{"value":"1526-3347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,1]]}}}