{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:06:58Z","timestamp":1770271618423,"version":"3.49.0"},"reference-count":80,"publisher":"American Academy of Pediatrics (AAP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:p>Spondyloarthritis (SpA) is a blanket term encompassing entities such as enthesitis-related arthritis, nonradiographic axial SpA, and ankylosing spondylitis. These diseases share many clinical features, including a predilection for inflammation of the entheses and the sacroiliac joints. The nomenclature is based on the evolution of the classification of the disease and the age of the patient. SpA has a prevalence of approximately 1% of the population of the United States, with 10% to 20% of patients experiencing the onset during childhood. Children with onset of arthritis before age 16 years are classified as having juvenile idiopathic arthritis. Children with enthesitis and\/or sacroiliitis are further classified as belonging to the enthesitis-related arthritis subtype of juvenile idiopathic arthritis. The initial manifestations can be subtle and will usually include a peripheral pattern of arthritis and enthesitis. It may take several years for axial disease to develop in children. Except for an association with the human leukocyte antigen (HLA-B27) serotype, there are no laboratory markers for the disease, and the radiographic findings are often negative. A careful clinical evaluation for evidence of inflammation in the entheses and the joints and a search for comorbidities are required. Magnetic resonance imaging facilitates the early detection of sacroiliitis, an important feature that may be clinically silent. Because recent studies indicate that earlier introduction of therapy can help achieve better outcomes, rapid identification and treatment of children with SpA is essential.<\/jats:p>","DOI":"10.1542\/pir.2020-000810","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T09:35:11Z","timestamp":1635759311000},"page":"581-589","source":"Crossref","is-referenced-by-count":7,"title":["Update on Juvenile Spondyloarthritis"],"prefix":"10.1542","volume":"42","author":[{"given":"Lita","family":"Aeder","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Brookdale University Hospital and Medical Center, New York, NY; and State University of New York Health Science Center at Brooklyn, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen B.","family":"Onel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Hospital for Special Surgery, New York, NY; and Department of Clinical Pediatrics, Weill Cornell Medicine, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"issue":"2","key":"2022032113472985700_B1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"issue":"1","key":"2022032113472985700_B2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1546-0096-10-14","article-title":"The assessment of the spondyloarthritis international society concept and criteria for the classification of axial spondyloarthritis and peripheral spondyloarthritis: a critical appraisal for the pediatric rheumatologist","volume":"10","author":"Burgos-Vargas","year":"2012","journal-title":"Pediatr Rheumatol Online J"},{"issue":"4","key":"2022032113472985700_B3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria","volume":"27","author":"van der Linden","year":"1984","journal-title":"Arthritis Rheum"},{"issue":"2","key":"2022032113472985700_B4","first-page":"85","article-title":"Criteria of the classification of spondylarthropathies [in French]","volume":"57","author":"Amor","year":"1990","journal-title":"Rev Rhum Mal Osteoartic"},{"issue":"10","key":"2022032113472985700_B5","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/art.1780341003","article-title":"The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy","volume":"34","author":"Dougados","year":"1991","journal-title":"Arthritis Rheum"},{"issue":"12","key":"2022032113472985700_B6","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00296-017-3837-8","article-title":"The performance of classification criteria for juvenile spondyloarthropathies","volume":"37","author":"Adrovic","year":"2017","journal-title":"Rheumatol Int"},{"issue":"6","key":"2022032113472985700_B7","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/ard.2009.108233","article-title":"The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection","volume":"68","author":"Rudwaleit","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2022032113472985700_B8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/ard.2010.133645","article-title":"The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general","volume":"70","author":"Rudwaleit","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"2022032113472985700_B9","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/ard.2008.104018","article-title":"The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis","volume":"68","author":"Sieper","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"2022032113472985700_B10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/MAJ.0b013e31820f8c99","article-title":"Epidemiology of spondyloarthritis in North America","volume":"341","author":"Reveille","year":"2011","journal-title":"Am J Med Sci"},{"issue":"3","key":"2022032113472985700_B11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3109\/03009748309098542","article-title":"Ankylosing spondylitis of juvenile onset: comparison with adult onset disease","volume":"12","author":"Garc\u00eda-Morteo","year":"1983","journal-title":"Scand J Rheumatol"},{"issue":"2","key":"2022032113472985700_B12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/ard.30.2.138","article-title":"Radiological manifestations of ankylosing spondylitis according to age at onset","volume":"30","author":"Riley","year":"1971","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"2022032113472985700_B13","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/art.10444","article-title":"Long-term outcome in patients with juvenile idiopathic arthritis","volume":"46","author":"Minden","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"9","key":"2022032113472985700_B35","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1136\/ard.2008.092304","article-title":"Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis","volume":"68","author":"O\u2019Shea","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"2022032113472985700_B14","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/art.1780140505","article-title":"Juvenile ankylosing spondylitis","volume":"14","author":"Ladd","year":"1971","journal-title":"Arthritis Rheum"},{"issue":"3","key":"2022032113472985700_B15","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/art.39464","article-title":"Sexual dimorphism in the Th17 signature of ankylosing spondylitis","volume":"68","author":"Gracey","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"9563","key":"2022032113472985700_B16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","article-title":"Juvenile idiopathic arthritis","volume":"369","author":"Ravelli","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"2022032113472985700_B17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/art.38197","article-title":"Detection of enthesitis in children with enthesitis-related arthritis: dolorimetry compared to ultrasonography","volume":"66","author":"Weiss","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"2022032113472985700_B18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4274\/balkanmedj.2017.0111","article-title":"Juvenile idiopathic arthritis","volume":"34","author":"Barut","year":"2017","journal-title":"Balkan Med J"},{"issue":"8","key":"2022032113472985700_B19","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s10067-017-3733-3","article-title":"Prominent midfoot involvement in children with enthesitis-related arthritis category of juvenile idiopathic arthritis","volume":"36","author":"Phatak","year":"2017","journal-title":"Clin Rheumatol"},{"issue":"11","key":"2022032113472985700_B20","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.3899\/jrheum.100090","article-title":"Early predictors of juvenile sacroiliitis in enthesitis-related arthritis","volume":"37","author":"Pagnini","year":"2010","journal-title":"J Rheumatol"},{"issue":"2","key":"2022032113472985700_B21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.berh.2005.12.002","article-title":"The spectrum of paediatric and adolescent rheumatology","volume":"20","author":"Davies","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"4","key":"2022032113472985700_B22","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.pcl.2018.03.006","article-title":"Juvenile spondyloarthritis: a distinct form of juvenile arthritis","volume":"65","author":"Weiss","year":"2018","journal-title":"Pediatr Clin North Am"},{"issue":"11","key":"2022032113472985700_B23","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.3899\/jrheum.100014","article-title":"Spondyloarthritis in a pediatric population: risk factors for sacroiliitis","volume":"37","author":"Stoll","year":"2010","journal-title":"J Rheumatol"},{"issue":"12","key":"2022032113472985700_B24","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.3899\/jrheum.120642","article-title":"Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison to other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry","volume":"39","author":"Weiss","year":"2012","journal-title":"J Rheumatol"},{"issue":"6","key":"2022032113472985700_B25","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.berh.2018.07.003","article-title":"Pain in spondyloarthritis: a neuro-immune interaction","volume":"31","author":"Pathan","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"8","key":"2022032113472985700_B26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/ard.56.8.488","article-title":"The LMP2 polymorphism is associated with susceptibility to acute anterior uveitis in HLA-B27 positive juvenile and adult Mexican subjects with ankylosing spondylitis","volume":"56","author":"Maksymowych","year":"1997","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"2022032113472985700_B27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s11926-012-0267-1","article-title":"Uveitis in seronegative arthritis","volume":"14","author":"Wendling","year":"2012","journal-title":"Curr Rheumatol Rep"},{"issue":"3","key":"2022032113472985700_B28","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.rdc.2012.08.012","article-title":"Pathophysiology and role of the gastrointestinal system in spondyloarthritides","volume":"38","author":"Jacques","year":"2012","journal-title":"Rheum Dis Clin North Am"},{"issue":"10","key":"2022032113472985700_B29","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.3899\/jrheum.110508","article-title":"Fecal calprotectin in children with the enthesitis-related arthritis subtype of juvenile idiopathic arthritis","volume":"38","author":"Stoll","year":"2011","journal-title":"J Rheumatol"},{"issue":"4","key":"2022032113472985700_B30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/BOR.0000000000000185","article-title":"Juvenile spondyloarthritis","volume":"27","author":"Gmuca","year":"2015","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"2022032113472985700_B31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.rdc.2013.06.002","article-title":"Update on juvenile spondyloarthritis","volume":"39","author":"Ramanathan","year":"2013","journal-title":"Rheum Dis Clin North Am"},{"issue":"5","key":"2022032113472985700_B32","first-page":"S40","article-title":"The conundrum of juvenile psoriatic arthritis","volume":"33","author":"Ravelli","year":"2015","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"2022032113472985700_B33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrrheum.2012.37","article-title":"New advances in juvenile spondyloarthritis","volume":"8","author":"Tse","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"10","key":"2022032113472985700_B34","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0002-9149(99)80672-9","article-title":"Prevalence of cardiac manifestations of juvenile ankylosing spondylitis","volume":"75","author":"Stamato","year":"1995","journal-title":"Am J Cardiol"},{"issue":"1","key":"2022032113472985700_B36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12969-018-0238-9","article-title":"Clinical features of children with enthesitis-related juvenile idiopathic arthritis \/ juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre","volume":"16","author":"Goirand","year":"2018","journal-title":"Pediatr Rheumatol Online J"},{"issue":"70","key":"2022032113472985700_B37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.15557\/JoU.2017.0025","article-title":"Imaging of juvenile spondyloarthritis, part I: classifications and radiographs","volume":"17","author":"Sudo\u0142-Szopi\u0144ska","year":"2017","journal-title":"J Ultrason"},{"issue":"6","key":"2022032113472985700_B38","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/ard.2008.101501","article-title":"New criteria for inflammatory back pain in patients with chronic back pain: a real patient exercise by experts from the Assessment of SpondyloArthritis international Society (ASAS)","volume":"68","author":"Sieper","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"2022032113472985700_B39","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s10067-008-0907-z","article-title":"The value of sacroiliac pain provocation tests in early active sacroiliitis","volume":"27","author":"Ozgocmen","year":"2008","journal-title":"Clin Rheumatol"},{"issue":"4","key":"2022032113472985700_B40","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/ard.30.4.381","article-title":"Normal range of spinal mobility: an objective clinical study","volume":"30","author":"Moll","year":"1971","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"2022032113472985700_B41","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1136\/ard.28.6.584","article-title":"Measurement of back movement","volume":"28","author":"Macrae","year":"1969","journal-title":"Ann Rheum Dis"},{"issue":"25","key":"2022032113472985700_B42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1546-0096-12-25","article-title":"Magnetic resonance imaging findings in juvenile spondyloarthropathy and effects of treatment observed on subsequent imaging","volume":"12","author":"Lin","year":"2014","journal-title":"Pediatr Rheumatol Online J"},{"issue":"1","key":"2022032113472985700_B43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13075-018-1642-8","article-title":"Radiographs in screening for sacroiliitis in children: what is the value?","volume":"20","author":"Weiss","year":"2018","journal-title":"Arthritis Res Ther"},{"issue":"70","key":"2022032113472985700_B44","doi-asserted-by":"crossref","first-page":"176","DOI":"10.15557\/JoU.2017.0026","article-title":"Imaging of juvenile spondyloarthritis, part II: ultrasonography and magnetic resonance imaging","volume":"17","author":"Sudo\u0142-Szopi\u0144ska","year":"2017","journal-title":"J Ultrason"},{"issue":"1","key":"2022032113472985700_B45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5334\/jbr-btr.1198","article-title":"Diagnostic value of MRI of the sacroiliac joints in juvenile spondyloarthritis","volume":"100","author":"Herregods","year":"2016","journal-title":"J Belg Soc Radiol"},{"key":"2022032113472985700_B46","first-page":"S292","article-title":"Whole body magnetic resonance imaging in juvenile spondyloarthritis: will it provide vital information compared to clinical exam alone?","volume":"63","author":"Rachlis","year":"2011","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"2022032113472985700_B47","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/acr.20444","article-title":"Ultrasonography for detecting enthesitis in juvenile idiopathic arthritis","volume":"63","author":"Jousse-Joulin","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"5","key":"2022032113472985700_B48","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/1971400917697503","article-title":"Back pain and scoliosis in children: when to image, what to consider","volume":"30","author":"Calloni","year":"2017","journal-title":"Neuroradiol J"},{"key":"2022032113472985700_B49","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1546-0096-7-10","article-title":"Review for the generalist: evaluation of pediatric hip pain","volume":"7","author":"Houghton","year":"2009","journal-title":"Pediatr Rheumatol Online J"},{"issue":"1","key":"2022032113472985700_B50","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/art.10916","article-title":"Enthesitis of spondyloarthritis can masquerade as Osgood-Schlatter disease by radiographic findings","volume":"49","author":"Olivieri","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"5","key":"2022032113472985700_B51","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s11926-011-0202-x","article-title":"Pathophysiology of spondyloarthritis","volume":"13","author":"Ronneberger","year":"2011","journal-title":"Curr Rheumatol Rep"},{"issue":"4","key":"2022032113472985700_B52","first-page":"272","article-title":"Chronic recurrent multifocal osteomyelitis: a case report","volume":"54","author":"A\u00e7o\u011flu","year":"2019","journal-title":"Turk Pediatri Ars"},{"issue":"5","key":"2022032113472985700_B53","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nrrheum.2012.41","article-title":"Genetics of spondyloarthritis: beyond the MHC","volume":"8","author":"Reveille","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"2022032113472985700_B54","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.berh.2018.07.012","article-title":"The role of HLA-B*27 in spondyloarthritis","volume":"31","author":"Colbert","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"1","key":"2022032113472985700_B55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12969-016-0076-6","article-title":"Biologic agents in juvenile spondyloarthropathies","volume":"14","author":"Katsicas","year":"2016","journal-title":"Pediatr Rheumatol Online J"},{"issue":"5","key":"2022032113472985700_B56","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s10067-018-4388-4","article-title":"Dendritic cells in the pathogenesis of ankylosing spondylitis and axial spondyloarthritis","volume":"38","author":"Slobodin","year":"2019","journal-title":"Clin Rheumatol"},{"issue":"2","key":"2022032113472985700_B57","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2217\/ijr.12.84","article-title":"Immunopathogenesis of ankylosing spondylitis","volume":"8","author":"Kenna","year":"2013","journal-title":"Int J Clin Rheumatol"},{"issue":"1","key":"2022032113472985700_B58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/BOR.0000000000000132","article-title":"The biology of IL-23 and IL-17 and their therapeutic targeting in rheumatic diseases","volume":"27","author":"Sherlock","year":"2015","journal-title":"Curr Opin Rheumatol"},{"issue":"2","key":"2022032113472985700_B59","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/1744666X.2019.1561281","article-title":"The advent of IL-17A blockade in ankylosing spondylitis: secukinumab, ixekizumab and beyond","volume":"15","author":"Dubash","year":"2019","journal-title":"Expert Rev Clin Immunol"},{"issue":"6","key":"2022032113472985700_B60","first-page":"773","article-title":"Increased gut permeability in juvenile chronic arthritides: a multivariate analysis of the diagnostic parameters","volume":"18","author":"Picco","year":"2000","journal-title":"Clin Exp Rheumatol"},{"issue":"6","key":"2022032113472985700_B61","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/s13075-014-0486-0","article-title":"Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis","volume":"16","author":"Stoll","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"2022032113472985700_B62","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/acr.23870","article-title":"2019 American College of Rheumatology\/Arthritis Foundation guideline for the treatment of juvenile idiopathic arthritis: therapeutic approaches for non-systemic polyarthritis, sacroiliitis, and enthesitis","volume":"71","author":"Ringold","year":"2019","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"5","key":"2022032113472985700_B63","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/MAJ.0b013e3182514043","article-title":"Juvenile spondyloarthritis treatment recommendations","volume":"343","author":"Tse","year":"2012","journal-title":"Am J Med Sci"},{"issue":"8","key":"2022032113472985700_B64","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1002\/art.39145","article-title":"Efficacy and safety of etanercept in patients with the enthesitis-related arthritis category of juvenile idiopathic arthritis: results from a phase III randomized, double-blind study","volume":"67","author":"Horneff","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"2022032113472985700_B65","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/acr.22657","article-title":"A randomized, double-blind, placebo-controlled multicenter study of adalimumab in pediatric patients with enthesitis-related arthritis","volume":"67","author":"Burgos-Vargas","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2022032113472985700_B66","first-page":"S319","article-title":"Efficacy, safety, and tolerability of infliximab in juvenile-onset spondyloarthropathies (JO-SpA): results of the three-month, randomized, double-blind, placebo-controlled trial phase [abstract]","volume":"56","author":"Burgos-Vargas","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"9999","key":"2022032113472985700_B67","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0140-6736(15)61134-5","article-title":"Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"386","author":"McInnes","year":"2015","journal-title":"Lancet"},{"issue":"26","key":"2022032113472985700_B68","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1056\/NEJMoa1505066","article-title":"Secukinumab, an interleukin-17A inhibitor, in ankylosing spondylitis","volume":"373","author":"Baeten","year":"2015","journal-title":"N Engl J Med"},{"issue":"11","key":"2022032113472985700_B69","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1002\/art.22181","article-title":"Long-term outcome and prognostic factors in enthesitis-related arthritis: a case-control study","volume":"54","author":"Flat\u00f8","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"1","key":"2022032113472985700_B70","doi-asserted-by":"crossref","first-page":"e000366","DOI":"10.1136\/rmdopen-2016-000366","article-title":"Course of patients with juvenile spondyloarthritis during 4\u2005years of observation, juvenile part of GESPIC","volume":"3","author":"Wei\u00df","year":"2017","journal-title":"RMD Open"},{"issue":"8","key":"2022032113472985700_B71","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1136\/annrheumdis-2014-205178","article-title":"Higher disease activity leads to more structural damage in the spine in ankylosing spondylitis: 12-year longitudinal data from the OASIS cohort","volume":"73","author":"Ramiro","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"2022032113472985700_B72","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1002\/art.23901","article-title":"Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis","volume":"58","author":"van der Heijde","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"10","key":"2022032113472985700_B73","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/art.38070","article-title":"The impact of tumor necrosis factor \u03b1 inhibitors on radiographic progression in ankylosing spondylitis","volume":"65","author":"Haroon","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"1","key":"2022032113472985700_B74","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/annrheumdis-2017-211544","article-title":"TNF blockers inhibit spinal radiographic progression in ankylosing spondylitis by reducing disease activity: results from the Swiss Clinical Quality Management cohort","volume":"77","author":"Molnar","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2022032113472985700_B75","doi-asserted-by":"crossref","first-page":"X20906040","DOI":"10.1177\/1759720X20906040","article-title":"Biologic therapy and spinal radiographic progression in patients with axial spondyloarthritis: a structured literature review","volume":"12","author":"Baraliakos","year":"2020","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"5","key":"2022032113472985700_B76","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/rheumatology\/key375","article-title":"Secukinumab shows sustained efficacy and low structural progression in ankylosing spondylitis: 4-year results from the MEASURE 1 study","volume":"58","author":"Braun","year":"2019","journal-title":"Rheumatology (Oxford)"},{"issue":"12","key":"2022032113472985700_B77","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.3899\/jrheum.110427","article-title":"Attainment of inactive disease status following initiation of TNF-\u03b1 inhibitor therapy for juvenile idiopathic arthritis: enthesitis-related arthritis predicts persistent active disease","volume":"38","author":"Donnithorne","year":"2011","journal-title":"J Rheumatol"},{"issue":"5","key":"2022032113472985700_B78","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.semarthrit.2016.10.008","article-title":"Efficacy of biologic therapy across individual juvenile idiopathic arthritis subtypes: a systematic review","volume":"46","author":"Davies","year":"2017","journal-title":"Semin Arthritis Rheum"},{"issue":"4","key":"2022032113472985700_B79","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/art.40750","article-title":"Sacroiliac joint ankylosis in young spondyloarthritis patients receiving biologic therapy: observation of serial magnetic resonance imaging scans","volume":"71","author":"Bray","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"4","key":"2022032113472985700_B80","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/acr.23709","article-title":"Time of disease-modifying antirheumatic drug start in juvenile idiopathic arthritis and the likelihood of a drug-free remission in young adulthood","volume":"71","author":"Minden","year":"2019","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["Pediatrics In Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatricsinreview\/article-pdf\/42\/11\/581\/1270190\/pedsinreview_2020000810.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatricsinreview\/article-pdf\/42\/11\/581\/1270190\/pedsinreview_2020000810.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T01:51:17Z","timestamp":1699753877000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatricsinreview\/article\/42\/11\/581\/181211\/Update-on-Juvenile-Spondyloarthritis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":80,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,1]]},"published-print":{"date-parts":[[2021,11,1]]}},"URL":"https:\/\/doi.org\/10.1542\/pir.2020-000810","relation":{},"ISSN":["0191-9601","1526-3347"],"issn-type":[{"value":"0191-9601","type":"print"},{"value":"1526-3347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,1]]}}}