{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:28:23Z","timestamp":1793179703802,"version":"4.5.0"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Early-onset sepsis can cause significant morbidity and mortality in newborn infants. Risk factors for sepsis include birth to mothers with inadequately treated maternal group B Streptococcus colonization, intra-amniotic infection, maternal temperature greater than 100.4\u00b0F (&amp;gt;38\u00b0C), rupture of membranes greater than 18 hours, and preterm labor. The organisms that most commonly cause early-onset sepsis include group B Streptococcus, Escherichia coli, and viridans streptococci. Infants often present within the first 24 hours after birth with clinical signs of sepsis, with respiratory distress as the most common presenting symptom. However, infants can also have respiratory distress from noninfectious etiologies. Therefore, when physicians are faced with asymptomatic infants with risk factors or infants with respiratory distress without risk factors, there is a delicate balance between empirically treating with antibiotics and observing these infants without treating.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/pir.2020-001164","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T03:09:37Z","timestamp":1672542577000},"page":"14-22","source":"Crossref","is-referenced-by-count":28,"title":["Early-Onset Sepsis in Newborns"],"prefix":"10.1542","volume":"44","author":[{"given":"Courtney","family":"Briggs-Steinberg","sequence":"first","affiliation":[{"name":"*Division of Neonatology, Department of Pediatrics, Staten Island University Hospital, Northwell Health, Staten Island, NY"},{"name":"\u2020Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Roth","sequence":"additional","affiliation":[{"name":"*Division of Neonatology, Department of Pediatrics, Staten Island University Hospital, Northwell Health, Staten Island, NY"},{"name":"\u2020Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2023,1,1]]},"reference":[{"issue":"3","key":"2023010103091284100_B1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"Fleischmann-Struzek","year":"2018","journal-title":"Lancet Respir Med"},{"issue":"1","key":"2023010103091284100_B2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/CMR.00031-13","article-title":"Early-onset neonatal sepsis","volume":"27","author":"Simonsen","year":"2014","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"2023010103091284100_B3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41390-020-0850-5","article-title":"Neonatal sepsis: need for consensus definition, collaboration and core outcomes","volume":"88","author":"Molloy","year":"2020","journal-title":"Pediatr Res"},{"issue":"6","key":"2023010103091284100_B4","doi-asserted-by":"crossref","first-page":"e20182894","DOI":"10.1542\/peds.2018-2894","article-title":"Management of neonates born at \u226535 0\/7 weeks\u2019 gestation with suspected or proven early-onset bacterial sepsis","volume":"142","author":"Puopolo","year":"2018","journal-title":"Pediatrics"},{"issue":"2","key":"2023010103091284100_B5","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1097\/AOG.0000000000002236","article-title":"Committee Opinion No. 712: intrapartum management of Intraamniotic Infection","volume":"130","author":"Committee on Obstetric Practice","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"6","key":"2023010103091284100_B6","doi-asserted-by":"crossref","first-page":"e20162013","DOI":"10.1542\/peds.2016-2013","article-title":"Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014","volume":"138","author":"Schrag","year":"2016","journal-title":"Pediatrics"},{"key":"2023010103091284100_B7","volume-title":"Remington and Klein\u2019s Infectious Diseases of the Fetus and Newborn Infant","author":"Wilson","year":"2015","edition":"8th ed."},{"issue":"2","key":"2023010103091284100_B8","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1097\/AOG.0000000000003668","article-title":"Prevention of group B streptococcal early-onset disease in newborns: ACOG Committee Opinion, Number 797","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"key":"2023010103091284100_B9","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1093\/cid\/cix655","article-title":"Risk of early-onset neonatal group B streptococcal disease with maternal colonization worldwide: systematic review and meta-analyses","volume":"65","author":"Russell","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"2","key":"2023010103091284100_B10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.clp.2009.12.001","article-title":"Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis","volume":"37","author":"Benitz","year":"2010","journal-title":"Clin Perinatol"},{"issue":"2","key":"2023010103091284100_B11","doi-asserted-by":"crossref","first-page":"e20191881","DOI":"10.1542\/peds.2019-1881","article-title":"Committee on Fetus and Newborn; Committee on Infectious Diseases. 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