{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T15:09:03Z","timestamp":1746716943391,"version":"3.40.5"},"reference-count":40,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:p>We describe a 15-year-old boy who presented with low back pain due to vertebral compression fractures, growth deceleration, excessive weight gain, rounded facies, dorsocervical fat pad, and hypertension. He was diagnosed as having Cushing syndrome (CS) due to primary pigmented nodular adrenocortical disease resulting in excess cortisol produced by the adrenal glands, leading to disruption of the hypothalamic-pituitary-adrenal axis. The most common cause of CS is exogenous glucocorticoids, with endogenous causes being extremely rare, often leading to delay in diagnosis or misdiagnosis. Herein, we review clinical presentation, screening for hypercortisolism, and decision-making in the diagnosis of CS, as well as therapeutic approaches. The wide range of clinical presentations in pediatric CS and the rarity of the condition can lead to difficulty in the recognition, diagnosis, and subsequent management of these patients. CS can be difficult to differentiate from more common exogenous obesity, and outpatient screening of cortisol excess is challenging. Early recognition and treatment of CS is necessary to avoid multisystemic complications, and patients with suspected endogenous CS should be referred to a tertiary care center with experienced pediatric endocrinology and surgery specialists. Further confirmatory diagnostic tests are necessary to distinguish corticotropin-independent from corticotropin-dependent forms of CS, including a high-dose dexamethasone suppression test, a corticotropin-releasing hormone stimulation test, and imaging. There can be challenges to the evaluation of CS, including complex inpatient testing and difficulty with localization on imaging. Long-term sequelae of CS, including adrenal insufficiency, obesity, hypertension, and mental health disorders, may remain despite definitive surgical treatment, meriting close follow-up with the primary care clinician and subspecialists.<\/jats:p>","DOI":"10.1542\/pir.2022-005732","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T03:04:52Z","timestamp":1704078292000},"page":"14-25","source":"Crossref","is-referenced-by-count":0,"title":["Cushing Syndrome in Childhood"],"prefix":"10.1542","volume":"45","author":[{"given":"Anthony","family":"Parish","sequence":"first","affiliation":[{"name":"*Pediatric Endocrinology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clement","family":"Cheung","sequence":"additional","affiliation":[{"name":"*Pediatric Endocrinology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ryabets-Lienhard","sequence":"additional","affiliation":[{"name":"*Pediatric 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