{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:59:51Z","timestamp":1787241591777,"version":"build-2736575974"},"reference-count":12,"publisher":"American Academy of Pediatrics (AAP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,1]]},"DOI":"10.1542\/pir.28.7.259","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T19:39:42Z","timestamp":1639078782000},"page":"259-268","source":"Crossref","is-referenced-by-count":74,"title":["Sickle Cell Disease"],"prefix":"10.1542","volume":"28","author":[{"given":"M. Catherine","family":"Driscoll","sequence":"first","affiliation":[{"name":"Director, Hematology Program, Children's Hospital at Montefiore, Bronx, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"2021120906194644200_R1","doi-asserted-by":"crossref","unstructured":"Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med.\u20081998;339:5\u201311","DOI":"10.1056\/NEJM199807023390102"},{"key":"2021120906194644200_R2","doi-asserted-by":"crossref","unstructured":"Ashley-Koch A, Yang Q, Olney RS. Sickle hemoglobin allele and sickle cell disease: A HuGE Review. Am J Epidemiol.\u20082000;151:839\u2013845","DOI":"10.1093\/oxfordjournals.aje.a010288"},{"key":"2021120906194644200_R3","doi-asserted-by":"crossref","unstructured":"Gladwin MT, Sachdev V, Jison ML, et al. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med.\u20082004;350:886\u2013895","DOI":"10.1056\/NEJMoa035477"},{"key":"2021120906194644200_R4","doi-asserted-by":"crossref","unstructured":"Machado RF, Anthi A, Steinberg MH, et al. N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. JAMA.\u20082006;296:310\u2013318","DOI":"10.1001\/jama.296.3.310"},{"key":"2021120906194644200_R5","doi-asserted-by":"crossref","unstructured":"Miller ST, Sleeper LA, Pegelow CH. Prediction of adverse outcomes in children with sickle cell anemia. N Engl J Med.\u20082000;342:83\u201389","DOI":"10.1056\/NEJM200001133420203"},{"key":"2021120906194644200_R6","doi-asserted-by":"crossref","unstructured":"Powers DR, Chan LS, Hiti A, et al. Outcome of sickle cell anemia. Medicine.\u20082005;84:363\u2013375","DOI":"10.1097\/01.md.0000189089.45003.52"},{"key":"2021120906194644200_R7","doi-asserted-by":"crossref","unstructured":"Steinberg MH. Management of sickle cell disease. N Engl J Med.\u20081999;340:1021\u20131030","DOI":"10.1056\/NEJM199904013401307"},{"key":"2021120906194644200_R8","doi-asserted-by":"crossref","unstructured":"Steinberg MH, Barton F, Castro O, et al. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia. JAMA.\u20082003;289:1645\u20131651","DOI":"10.1001\/jama.289.13.1645"},{"key":"2021120906194644200_R9","doi-asserted-by":"crossref","unstructured":"Stuart MJ, Nagel RL. Sickle cell disease. Lancet.\u20082004;364:1343\u20131360","DOI":"10.1016\/S0140-6736(04)17192-4"},{"key":"2021120906194644200_R10","doi-asserted-by":"crossref","unstructured":"Vichinsky EP. New therapies in sickle cell disease. Lancet.\u20082002;360:629\u2013631","DOI":"10.1016\/S0140-6736(02)09776-3"},{"key":"2021120906194644200_R11","doi-asserted-by":"crossref","unstructured":"Vichinsky EP, Neumayr LD, Earles AN, et al. Causes and outcomes of the acute chest syndrome in sickle cell disease. N Engl J Med.\u20082000;342:1855\u20131865","DOI":"10.1056\/NEJM200006223422502"},{"key":"2021120906194644200_R12","doi-asserted-by":"crossref","unstructured":"Wilimas JA, Flynn PM, Harris S. A randomized study of outpatient treatment with ceftriaxone for selected children with sickle cell disease. N Engl J Med.\u20081993;329:472\u2013476","DOI":"10.1056\/NEJM199308123290705"}],"container-title":["Pediatrics In Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatricsinreview\/article-pdf\/28\/7\/259\/998004\/zpx00707000259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatricsinreview\/article-pdf\/28\/7\/259\/998004\/zpx00707000259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T09:26:37Z","timestamp":1640078797000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatricsinreview\/article\/28\/7\/259\/33990\/Sickle-Cell-Disease"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,1]]},"references-count":12,"aliases":["10.1542\/pir.28-7-259","10.1542\/pir.28-7-259"],"journal-issue":{"issue":"7","published-online":{"date-parts":[[2007,7,1]]},"published-print":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1542\/pir.28.7.259","relation":{},"ISSN":["0191-9601","1526-3347"],"issn-type":[{"value":"0191-9601","type":"print"},{"value":"1526-3347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,1]]}}}