{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:16:13Z","timestamp":1761765373460,"version":"3.40.5"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>Our aim was to validate a strategy for assessing the risk of significant hyperbilirubinemia in newborns with gestational ages of \u226535 weeks by combining predischarge bilirubin percentile data with gestational age data, for a European, predominantly white population.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>We conducted a prospective cohort study with 463 newborns with gestational ages of \u226535 weeks who were admitted to the well-infant nursery. Total bilirubin levels were measured daily until discharge and once after discharge, between the third and eighth days of life, by using a Bilicheck device (Respironics, Murrysville, PA). The values obtained (&amp;lt;52 hours) were plotted on an hour-specific bilirubin nomogram to determine the infant's bilirubin percentile, expressed as a risk zone. Patients were assigned to 1 of 3 risk groups (very low, low, or high) on the basis of a combination of risk zone and gestational age data and were monitored prospectively for the development of significant hyperbilirubinemia. The 95% confidence interval (CI) for the prevalence of significant hyperbilirubinemia was estimated with the binomial distribution method.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Forty-four infants (11%) developed significant neonatal hyperbilirubinemia. The risks of developing significant hyperbilirubinemia were 1.3% (95% CI: 0.2%\u20133.7%) for the very low risk group (n = 230 [58.1%]), 3.4% (95% CI: 0.7%\u20139.8%) for the low risk group (n = 86 [21.7%]), and 47.50% (95% CI: 36.2%\u201359.0%) for the high risk group (n = 80 [20.20%]).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The proposed strategy, based on predischarge bilirubin level and gestational age data, was a valid method for significant hyperbilirubinemia risk assessment in our population.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2009-2771","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T04:32:50Z","timestamp":1292301170000},"page":"e126-e131","source":"Crossref","is-referenced-by-count":6,"title":["Prospective Validation of a Novel Strategy for Assessing Risk of Significant Hyperbilirubinemia"],"prefix":"10.1542","volume":"127","author":[{"given":"Am\u00e9rico","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Divisions of General Pediatrics and"}]},{"given":"Sandra","family":"Costa","sequence":"additional","affiliation":[{"name":"Divisions of General Pediatrics and"}]},{"given":"Andreia","family":"Lopes","sequence":"additional","affiliation":[{"name":"Divisions of General Pediatrics and"}]},{"given":"Gustavo","family":"Rocha","sequence":"additional","affiliation":[{"name":"Neonatology, Pediatrics Department, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal; and"},{"name":"Services of Pediatrics and"}]},{"given":"Maria Beatriz","family":"Guedes","sequence":"additional","affiliation":[{"name":"Neonatology, Pediatrics Department, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal; and"}]},{"given":"Maria Jos\u00e9","family":"Centeno","sequence":"additional","affiliation":[{"name":"Neonatology, Pediatrics Department, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal; and"}]},{"given":"Jorge","family":"Silva","sequence":"additional","affiliation":[{"name":"Neonatology, Pediatrics Department, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal; and"}]},{"given":"Maria Gorett","family":"Silva","sequence":"additional","affiliation":[{"name":"Neonatology, Pediatrics Department, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal; and"}]},{"given":"Milton","family":"Severo","sequence":"additional","affiliation":[{"name":"Hygiene and Epidemiology, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Herc\u00edlia","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Neonatology, Pediatrics Department, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal; and"},{"name":"Services of Pediatrics 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