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The discussion leads to the conclusion that the prognostic significance of arrhythmia relationship with heart rate, and the consequence of heart rate on arrhythmogenesis, may vary according to the substrate present in the specific case and should be considered accordingly.<\/jats:p>","DOI":"10.15420\/aer.2018.12.3","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T09:03:56Z","timestamp":1539075836000},"page":"1","source":"Crossref","is-referenced-by-count":14,"title":["Arrhythmias and Heart Rate: Mechanisms and Significance of a Relationship"],"prefix":"10.15420","volume":"7","author":[{"given":"Antonio","family":"Zaza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Ronchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Malfatto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Dipartimento di Biotecnologie e Bioscienze, Universit\u00e0 degli Studi Milano-Bicocca, Milan, Italy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CARIM, Maastricht University, Maastricht, the Netherlands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Dipartimento di Biotecnologie e Bioscienze, Universit\u00e0 degli Studi Milano-Bicocca, Milan, Italy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Istituto Auxologico Italiano - IRCCS Ospedale San Luca, Milan, Italy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Boyett MR, Jewell BR. Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart. Prog Biophys Mol Biol 1980;36:1-52.","DOI":"10.1016\/0079-6107(81)90003-1"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"3862","DOI":"10.1016\/j.bpj.2009.02.017","article-title":"Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis","volume":"96","author":"Severi","year":"2009","unstructured":"2. Severi S, Corsi C, Rocchetti M, Zaza A. Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophys J 2009;96:3862-72.","journal-title":"Biophys J"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1161\/01.CIR.0000068344.54010.B3","article-title":"Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation","volume":"107","author":"Volders","year":"2003","unstructured":"3. Volders PG, Stengl M, van Opstal JM, et al. Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation. Circulation 2003;107:2753-60.","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1111\/j.1469-7793.2001.00721.x","article-title":"Rate-dependency of delayed rectifier currents during the guinea-pig ventricular action potential","volume":"534","author":"Rocchetti","year":"2001","unstructured":"4. Rocchetti M, Besana A, Gurrola GB, et al. Rate-dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J Physiol 2001;534:721-32.","journal-title":"J Physiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/301569a0","article-title":"Calcium channel modulation by neurotransmitters, enzymes and drugs","volume":"301","author":"Reuter","year":"1983","unstructured":"5. Reuter H. Calcium channel modulation by neurotransmitters, enzymes and drugs. Nature 1983;301:569-74.","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1161\/01.RES.27.3.361","article-title":"Electrogenic suppression of automaticity in sheep and dog Purkinje fibers","volume":"27","author":"Vassalle","year":"1970","unstructured":"6. Vassalle M. Electrogenic suppression of automaticity in sheep and dog Purkinje fibers. Circ Res 1970;27:361-77.","journal-title":"Circ Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1161\/01.CIR.97.25.2567","article-title":"Postrepolarization refractoriness versus conduction slowing caused by class I antiarrhythmic drugs: antiarrhythmic and proarrhythmic effects","volume":"97","author":"Kirchhof","year":"1998","unstructured":"7. Kirchhof PF, Fabritz CL, Franz MR. Postrepolarization refractoriness versus conduction slowing caused by class I antiarrhythmic drugs: antiarrhythmic and proarrhythmic effects. Circulation 1998;97:2567-74.","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1161\/01.RES.58.2.257","article-title":"The characteristics of post-repolarization refractoriness","volume":"58","author":"Davidenko","year":"1986","unstructured":"8. Davidenko JM, Antzelevitch C. Electrophysiological mechanisms underlying rate-dependent changes of refractoriness in normal and segmentally depressed canine Purkinje fibers. The characteristics of post-repolarization refractoriness. Circ Res 1986;58:257-68.","journal-title":"Circ Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jacbts.2017.02.002","article-title":"Increased afterload following myocardial infarction promotes conduction-dependent arrhythmias that are unmasked by hypokalemia","volume":"2","author":"Motloch","year":"2017","unstructured":"9. Motloch LJ, Ishikawa K, Xie C, et al. Increased afterload following myocardial infarction promotes conduction-dependent arrhythmias that are unmasked by hypokalemia. JACC Basic Transl Sci 2017;2:258-69.","journal-title":"JACC Basic Transl Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1161\/CIRCULATIONAHA.107.704890","article-title":"Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine","volume":"116","author":"Burashnikov","year":"2007","unstructured":"10. Burashnikov A, Di Diego JM, Zygmunt AC, et al. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation 2007;116:1449-57.","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.yjmcc.2009.07.027","article-title":"Control of the cardiac action potential: The role of repolarization dynamics","volume":"48","author":"Zaza","year":"2010","unstructured":"11. Zaza A. Control of the cardiac action potential: The role of repolarization dynamics. J Mol Cell Cardiol 2010;48: 106-11.","journal-title":"J Mol Cell Cardiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00395-009-0082-7","article-title":"Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations","volume":"105","author":"Barandi","year":"2010","unstructured":"12. Barandi L, Virag L, Jost N, et al. Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations. Basic Res Cardiol 2010;105:315-23.","journal-title":"Basic Res Cardiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/europace\/euv307","article-title":"Geometrical considerations in cardiac electrophysiology and arrhythmogenesis","volume":"18","author":"Winter","year":"2016","unstructured":"13. Winter J, Shattock MJ. Geometrical considerations in cardiac electrophysiology and arrhythmogenesis. Europace 2016;18:320-31.","journal-title":"Europace"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1161\/01.RES.64.5.977","article-title":"A role for L-type Ca2+ current","volume":"64","author":"January","year":"1989","unstructured":"14. January CT, Riddle JM. Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current. Circ Res 1989;64:977-90.","journal-title":"Circ Res"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Dunnink A, Stams TR, Bossu A, et al. Torsade de pointes arrhythmias arise at the site of maximal heterogeneity of repolarization in the chronic complete atrioventricular block dog. Europace 2017;19:858-65.","DOI":"10.1093\/europace\/euw087"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ejphar.2004.07.013","article-title":"Force-frequency relationship in intact mammalian ventricular myocardium: physiological and pathophysiological relevance","volume":"500","author":"Endoh","year":"2004","unstructured":"16. Endoh M. Force-frequency relationship in intact mammalian ventricular myocardium: physiological and pathophysiological relevance. Eur J Pharmacol 2004;500:73-86.","journal-title":"Eur J Pharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ceca.2007.04.002","article-title":"Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart","volume":"42","author":"Dibb","year":"2007","unstructured":"17. Dibb KM, Graham HK, Venetucci LA, et al. Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart. Cell Calcium 2007;42:503-12.","journal-title":"Cell Calcium"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/cvr\/cvm009","article-title":"The sarcoplasmic reticulum and arrhythmogenic calcium release","volume":"77","author":"Venetucci","year":"2008","unstructured":"18. Venetucci LA, Trafford AW, O'Neill SC, Eisner DA. The sarcoplasmic reticulum and arrhythmogenic calcium release. Cardiovasc Res 2008;77:285-92.","journal-title":"Cardiovasc Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.2174\/1381612820666141029100650","article-title":"Calcium store stability as an antiarrhythmic endpoint","volume":"21","author":"Zaza","year":"2015","unstructured":"19. Zaza A, Rocchetti M. Calcium store stability as an antiarrhythmic endpoint. Curr Pharm Des 2015;21:1053-61.","journal-title":"Curr Pharm Des"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0008-6363(02)00854-4","article-title":"SR calcium handling and calcium after-transients in a rabbit model of heart failure","volume":"58","author":"Baartscheer","year":"2003","unstructured":"20. Baartscheer A, Schumacher CA, Belterman CN, et al. SR calcium handling and calcium after-transients in a rabbit model of heart failure. Cardiovasc Res 2003;58:99-108.","journal-title":"Cardiovasc Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.yjmcc.2005.06.004","article-title":"Molecular correlates of repolarization alternans in cardiac myocytes","volume":"39","author":"Wan","year":"2005","unstructured":"21. Wan X, Laurita KR, Pruvot EJ, Rosenbaum DS. Molecular correlates of repolarization alternans in cardiac myocytes. J Mol Cell Cardiol 2005;39:419-428.","journal-title":"J Mol Cell Cardiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/20200","article-title":"Calmodulin supports both inactivation and facilitation of L-type calcium channels","volume":"399","author":"Zuhlke","year":"1999","unstructured":"22. Zuhlke RD, Pitt GS, Deisseroth K, et al. Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature 1999;399:159-62.","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.jelectrocard.2016.08.003","article-title":"Nonalternans repolarization variability and arrhythmia - the calcium connection","volume":"49","author":"Nemec","year":"2016","unstructured":"23. Nemec J. Nonalternans repolarization variability and arrhythmia - the calcium connection. 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Excitation-contraction coupling and mitochondrial energetics. Basic Res Cardiol 2007;102:369-92.","journal-title":"Basic Res Cardiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.yjmcc.2012.07.015","article-title":"SR and mitochondria: calcium cross-talk between kissing cousins","volume":"55","author":"GW","year":"2013","unstructured":"26. Dorn GW, Maack C. SR and mitochondria: calcium cross-talk between kissing cousins. J Mol Cell Cardiol 2013;55:42-9.","journal-title":"J Mol Cell Cardiol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","unstructured":"27. Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 2009;417:1-13.","journal-title":"Biochem J"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.yjmcc.2014.03.011","article-title":"Mitochondrial reactive oxygen species production and elimination","volume":"73","author":"Nickel","year":"2014","unstructured":"28. Nickel A, Kohlhaas M, Maack C. Mitochondrial reactive oxygen species production and elimination. J Mol Cell Cardiol 2014;73:26-33.","journal-title":"J Mol Cell Cardiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"11427","DOI":"10.1038\/srep11427","article-title":"Mitochondrial oxidative stress promotes atrial fibrillation","volume":"5","author":"Xie","year":"2015","unstructured":"29. Xie W, Santulli G, Reiken SR, et al. Mitochondrial oxidative stress promotes atrial fibrillation. Sci Rep 2015;5:11427.","journal-title":"Sci Rep"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.bbamcr.2012.08.016","article-title":"Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling","volume":"1833","author":"Niggli","year":"2013","unstructured":"30. Niggli E, Ullrich ND, Gutierrez D, et al. Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling. Biochim Biophys Acta 2013;1833:866-75.","journal-title":"Biochim Biophys Acta"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","unstructured":"31. Santulli G, Xie W, Reiken SR, Marks AR. Mitochondrial calcium overload is a key determinant in heart failure. Proc Natl Acad Sci USA 2015;112:11389-94.","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"32. Ward CA, Giles WR. Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes. J Physiol 1997;500(Pt 3):631-42.","DOI":"10.1113\/jphysiol.1997.sp022048"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.pharmthera.2008.06.001","article-title":"Pathophysiology and pharmacology of the cardiac \"late sodium current\"","volume":"119","author":"Zaza","year":"2008","unstructured":"33. Zaza A, Belardinelli L, Shryock JC. Pathophysiology and pharmacology of the cardiac \"late sodium current\". Pharmacol Ther 2008;119:326-39.","journal-title":"Pharmacol Ther"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/cvr\/cvq231","article-title":"Cardiac mitochondria and arrhythmias","volume":"88","author":"Brown","year":"2010","unstructured":"34. Brown DA, O'Rourke B. Cardiac mitochondria and arrhythmias. Cardiovasc Res 2010;88:241-9.","journal-title":"Cardiovasc Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/978-3-319-55330-6_10","article-title":"Functional role of mitochondria in arrhythmogenesis","volume":"982","author":"Gambardella","year":"2017","unstructured":"35. Gambardella J, Sorriento D, Ciccarelli M, et al. Functional role of mitochondria in arrhythmogenesis. Adv Exp Med Biol 2017;982:191-202.","journal-title":"Adv Exp Med Biol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1161\/CIRCRESAHA.110.226845","article-title":"Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis","volume":"108","author":"SG","year":"2011","unstructured":"36. Priori SG, Chen SR. Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis. Circ Res 2011;108:871-83.","journal-title":"Circ Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1161\/01.CIR.98.11.1125","article-title":"Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling","volume":"98","author":"Vos","year":"1998","unstructured":"37. Vos MA, de Groot S, Verduyn SC, et al. Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling. Circulation 1998;98:1125-35.","journal-title":"Circulation"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.hrthm.2014.11.018","article-title":"Electrocardiographic predictors of bradycardia-induced torsades de pointes in patients with acquired atrioventricular block","volume":"12","author":"Cho","year":"2015","unstructured":"38. Cho MS, Nam GB, Kim YG, et al. Electrocardiographic predictors of bradycardia-induced torsades de pointes in patients with acquired atrioventricular block. Heart Rhythm 2015;12:498-505.","journal-title":"Heart Rhythm"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/europace\/eur311","article-title":"Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog","volume":"14","author":"Dunnink","year":"2012","unstructured":"39. Dunnink A, van Opstal JM, Oosterhoff P, et al. Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog. Europace 2012;14:431-6.","journal-title":"Europace"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/cvr\/cvn266","article-title":"Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis","volume":"81","author":"Michael","year":"2009","unstructured":"40. Michael G, Xiao L, Qi XY, et al. Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovasc Res 2009;81:491-9.","journal-title":"Cardiovasc Res"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1113\/jphysiol.2006.105015","article-title":"Rate-dependency of beta-adrenergic modulation of repolarizing currents in the guinea-pig ventricle","volume":"574","author":"Rocchetti","year":"2006","unstructured":"41. Rocchetti M, Freli V, Perego V, et al. Rate-dependency of beta-adrenergic modulation of repolarizing currents in the guinea-pig ventricle. J Physiol 2006;574:183-93.","journal-title":"J Physiol"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"42. Sala L, Hegyi B, Bartolucci C, et al. Action potential contour contributes to species differences in repolarization response to beta-adrenergic stimulation. Europace 2017.","DOI":"10.1093\/europace\/eux236"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"43. Yanowitz R, Preston JB, Abildskov JA. Functional distribution of right and left stellate innervation to the ventricles: production of neurogenic electrocardiographic changes by unilateral alteration of sympathetic tone. Circ Res 1966;18:416-28. =","DOI":"10.1161\/01.RES.18.4.416"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1161\/01.RES.68.5.1191","article-title":"Sympathetic modulation of the relation between ventricular repolarization and cycle length","volume":"68","author":"Zaza","year":"1991","unstructured":"44. Zaza A, Malfatto G, Schwartz PJ. Sympathetic modulation of the relation between ventricular repolarization and cycle length. Circ Res 1991;68:1191-203.","journal-title":"Circ Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1253\/jcj.65.1087","article-title":"Spontaneous onset of torsade de pointes in long-QT syndrome and the role of sympathovagal imbalance","volume":"65","author":"Fujiki","year":"2001","unstructured":"45. Fujiki A, Nishida K, Mizumaki K, et al. Spontaneous onset of torsade de pointes in long-QT syndrome and the role of sympathovagal imbalance. Jpn Circ J 2001;65:1087-90.","journal-title":"Jpn Circ J"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1111\/j.1540-8159.2006.00506.x","article-title":"Ventricular repolarization and heart rate responses during cardiovascular autonomic function testing in LQT1 subtype of long QT syndrome","volume":"29","author":"Haapalahti","year":"2006","unstructured":"46. Haapalahti P, Viitasalo M, Perhonen M, et al. Ventricular repolarization and heart rate responses during cardiovascular autonomic function testing in LQT1 subtype of long QT syndrome. Pacing Clin Electrophysiol 2006;29:1122-9.","journal-title":"Pacing Clin Electrophysiol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1161\/01.CIR.103.1.89","article-title":"Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias","volume":"103","author":"Schwartz","year":"2001","unstructured":"47. Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 2001;103:89-95.","journal-title":"Circulation"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1113\/jphysiol.2011.218164","article-title":"Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits","volume":"590","author":"Liu","year":"2012","unstructured":"48. Liu GX, Choi BR, Ziv O, et al. Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits. J Physiol 2012;590:1171-80.","journal-title":"J Physiol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.yjmcc.2013.02.009","article-title":"Beta-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets","volume":"58","author":"Xie","year":"2013","unstructured":"49. Xie Y, Grandi E, Puglisi JL, ey al. Beta-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets. J Mol Cell Cardiol 2013;58:153-61.","journal-title":"J Mol Cell Cardiol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.hrthm.2010.12.030","article-title":"Circadian pattern of life-threatening ventricular arrhythmia in patients with sleep-disordered breathing and implantable cardioverter-defibrillators","volume":"8","author":"Zeidan-Shwiri","year":"2011","unstructured":"50. Zeidan-Shwiri T, Aronson D, Atalla K, et al. Circadian pattern of life-threatening ventricular arrhythmia in patients with sleep-disordered breathing and implantable cardioverter-defibrillators. Heart Rhythm 2011;8:657-62.","journal-title":"Heart Rhythm"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.jacc.2007.09.069","article-title":"Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome","volume":"51","author":"Schwartz","year":"2008","unstructured":"51. Schwartz PJ, Vanoli E, Crotti L, et al. Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome. J Am Coll Cardiol 2008;51:920-9.","journal-title":"J Am Coll Cardiol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1046\/j.1540-8167.2004.03096.x","article-title":"Heart rate dependence of the QT interval duration: differences among congenital long QT syndrome subtypes","volume":"15","author":"Nemec","year":"2004","unstructured":"52. Nemec J, Buncova M, Bulkova V, et al. Heart rate dependence of the QT interval duration: differences among congenital long QT syndrome subtypes. 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