{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:27:50Z","timestamp":1792290470562,"version":"4.4.0"},"reference-count":25,"publisher":"Radcliffe Medical Media Ltd","issue":"1","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arrhythm Electrophysiol Rev"],"published-print":{"date-parts":[[2019,3,12]]},"abstract":"<p>Brugada syndrome (BrS) represents an inherited disorder associated with risk of sudden cardiac death due to VF in patients without structural heart disease. Currently, BrS is diagnosed by typical cove-shaped ST-segment elevation &gt;2 mm in &gt;1 RV precordial lead V1, V2 occurring spontaneously or after a sodium-channel blocker provocation test without any further evidence of malignant arrhythmias. An ICD should always be implanted in symptomatic BrS patients to prevent sudden death, despite high rates of complications with these devices. In asymptomatic people, an electrophysiological study should be performed to evaluate the need for an ICD. The recent discovery of a functional substrate has revolutionised our approach to the pathophysiology and management of BrS. Promising new therapeutic options have emerged in the last 3 years. Ajmaline is able to determine the extension of the substrate by prolonging the duration and fragmentation of abnormal epicardial electrograms. Substrate ablation results in the disappearance of both coved-type ECG and ventricular tachycardia\/VF inducibility. These findings are clinically relevant, suggesting that epicardial ablation guided by ajmaline infusion may be an effective therapeutic option in BrS, potentially removing the need for ICD implantation.<\/p>","DOI":"10.15420\/aer.2018.73.2","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T10:19:54Z","timestamp":1552990794000},"page":"13-18","source":"Crossref","is-referenced-by-count":42,"title":["Brugada Syndrome: Progress in Diagnosis and Management"],"prefix":"10.15420","volume":"8","author":[{"given":"Carlo","family":"Pappone","sequence":"first","affiliation":[{"name":"Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Santinelli","sequence":"additional","affiliation":[{"name":"Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"A multicenter report","volume":"20","author":"Brugada","year":"1992","unstructured":"1. 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