{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:26:55Z","timestamp":1789792015822,"version":"4.0.1"},"reference-count":44,"publisher":"Radcliffe Medical Media Ltd","issue":"1","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arrhythm Electrophysiol Rev"],"published-print":{"date-parts":[[2019,3,12]]},"abstract":"<p>AF is strongly associated with a spectrum of cranial injuries including stroke and dementia. Dementia risk is seen in patients with and without a prior stroke and includes idiopathic forms of dementia, such as Alzheimer\u2019s disease. The initiation, use and efficacy of anticoagulation have been shown in multiple observational trials to have an impact on dementia risk. Cerebral hypoperfusion during AF can result in cognitive decline and patients with cranial atherosclerosis may have unique susceptibility. Therapies to carefully control the ventricular rate and catheter ablation have been shown in observational trials to lower dementia risk. There is a need for further research in multiple areas and the observational trials will require prospective trials confirmation. Recent guidelines for AF have advocated the initiation of effective anticoagulation, the treatment of associated disease conditions that may influence the progression of AF and catheter ablation, with long-term management of risk factors to lower risk of dementia.<\/p>","DOI":"10.15420\/aer.2018.75.2","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T10:19:54Z","timestamp":1552990794000},"page":"8-12","source":"Crossref","is-referenced-by-count":33,"title":["Atrial Fibrillation and Dementia: Exploring the Association, Defining Risks and Improving Outcomes"],"prefix":"10.15420","volume":"8","author":[{"given":"T Jared","family":"Bunch","sequence":"first","affiliation":[{"name":"Intermountain Medical Center Heart Institute, Murray, UT, US; Department of Internal Medicine, Stanford University, Palo Alto, CA, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oxana","family":"Galenko","sequence":"additional","affiliation":[{"name":"Intermountain Medical Center Heart Institute, Murray, UT, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G","family":"Graves","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Intermountain Medical Center Heart Institute, Murray, UT, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi T","family":"May","sequence":"additional","affiliation":[{"name":"Intermountain Medical Center Heart Institute, Murray, UT, US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study","volume":"285","author":"AS","year":"2001","unstructured":"1. 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