{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:14:47Z","timestamp":1783617287672,"version":"3.55.0"},"reference-count":31,"publisher":"Radcliffe Medical Media Ltd","issue":"3","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arrhythm Electrophysiol Rev"],"published-print":{"date-parts":[[2019,8,9]]},"abstract":"<p>Catheter ablation of ventricular tachycardia (VT) aims to treat the underlying arrhythmia substrate to prevent ICD therapies. The aim of this meta-analysis was to assess the safety and efficacy of VT ablation prior to or at the time of secondary prevention ICD implantation in patients with coronary artery disease, as compared with deferred VT ablation. Based on a systematic literature search, three randomised trials were considered eligible for inclusion in this analysis, and data on the number of patients with appropriate ICD shocks, appropriate ICD therapy, arrhythmic storm, death and major complications were extracted from each study. On pooled analysis, there was a significant reduction of appropriate ICD shocks (OR 2.58; 95% CI [1.54\u20134.34]; p&lt;0.001) and appropriate ICD therapies (OR 2.04; 95% CI [1.15\u20133.61]; p=0.015) in patients undergoing VT ablation at the time of ICD implantation without significant differences with respect to complications (OR 1.39; 95% CI [0.43\u20134.51]; p=0.581). Mortality did not differ between both groups (OR 1.30; 95% CI [0.60\u20132.45]; p=0.422). Preventive catheter ablation of VT in patients with coronary heart disease at the time of secondary prevention ICD implantation results in a significant reduction of appropriate ICD shocks and any appropriate ICD therapy compared with patients without or with deferred VT ablation. No significant difference with respect to complications or mortality was observed between both treatment strategies.<\/p>","DOI":"10.15420\/aer.2019.31.3","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T09:07:08Z","timestamp":1565687228000},"page":"173-179","source":"Crossref","is-referenced-by-count":12,"title":["Preventive Ventricular Tachycardia Ablation in Patients with Ischaemic Cardiomyopathy: Meta-analysis of Randomised Trials"],"prefix":"10.15420","volume":"8","author":[{"given":"Roland R","family":"Tilz","sequence":"first","affiliation":[{"name":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Eitel","sequence":"additional","affiliation":[{"name":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Lyan","sequence":"additional","affiliation":[{"name":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kivanc","family":"Yalin","sequence":"additional","affiliation":[{"name":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany; Usak University, Faculty of Medicine, Department of Cardiology, Usak, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Liosis","sequence":"additional","affiliation":[{"name":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Vogler","sequence":"additional","affiliation":[{"name":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Brueggemann","sequence":"additional","affiliation":[{"name":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Heeger","sequence":"additional","affiliation":[{"name":"University Heart Centre L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"AlTurki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, McGill University Health Centre, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Proietti","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","article-title":"2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"36","author":"Priori","year":"2015","unstructured":"1. Priori SG, Blomstrom-Lundqvist C, Mazzanti A, et al. 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J 2015;36:2793-867.","journal-title":"Eur Heart J"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s10840-005-4547-9","article-title":"Sudden cardiac death unresponsive to implantable defibrillator therapy: an urgent target for clinicians, industry and government","volume":"14","author":"Anderson","year":"2005","unstructured":"2. Anderson KP. Sudden cardiac death unresponsive to implantable defibrillator therapy: an urgent target for clinicians, industry and government. J Interv Card Electrophysiol 2005;14:71-8.","journal-title":"J Interv Card Electrophysiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.cjca.2014.11.023","article-title":"A systematic review and meta-analysis of the association between implantable cardioverter-defibrillator shocks and long-term mortality","volume":"31","author":"Proietti","year":"2015","unstructured":"3. Proietti R, Labos C, Davis M, et al. A systematic review and meta-analysis of the association between implantable cardioverter-defibrillator shocks and long-term mortality. Can J Cardiol 2015;31:270-7.","journal-title":"Can J Cardiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1056\/NEJMoa071098","article-title":"Prognostic importance of defibrillator shocks in patients with heart failure","volume":"359","author":"Poole","year":"2008","unstructured":"4. Poole JE, Johnson GW, Hellkamp AS, et al. Prognostic importance of defibrillator shocks in patients with heart failure. N Engl J Med 2008;359:1009-17.","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Manzoni GM, Castelnuovo G, Compare A, et al. Psychological effects of implantable cardioverter defibrillator shocks. A review of study methods. Front Psychol 2015;6:39.","DOI":"10.3389\/fpsyg.2015.00039"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Dinov B, Arya A, Bertagnolli L, et al. Early referral for ablation of scar-related ventricular tachycardia is associated with improved acute and long-term outcomes: results from the Heart Center of Leipzig ventricular tachycardia registry. Circ Arrhythm Electrophysiol 2014;7;1144-51.","DOI":"10.1161\/CIRCEP.114.001953"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","unstructured":"7. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.","journal-title":"Control Clin Trials"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Higgins JP, Altman DG, Gotzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928.","DOI":"10.1136\/bmj.d5928"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Acosta J, Cabanelas N, Penela D, et al. Long-term benefit of first-line peri-implantable cardioverter-defibrillator implant ventricular tachycardia-substrate ablation in secondary prevention patients. Europace 2017;19:976-82.","DOI":"10.1093\/europace\/euw096"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1093\/europace\/eut050","article-title":"Prophylactic catheter ablation for induced monomorphic ventricular tachycardia in patients with implantable cardioverter defibrillators as primary prevention","volume":"15","author":"Hayashi","year":"2013","unstructured":"10. Hayashi T, Fukamizu S, Hojo R, et al. Prophylactic catheter ablation for induced monomorphic ventricular tachycardia in patients with implantable cardioverter defibrillators as primary prevention. Europace 2013;15:1507-15.","journal-title":"Europace"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.joa.2014.09.007","article-title":"Prophylactic catheter ablation of ventricular tachycardia before cardioverter-defibrillator implantation in patients with non-ischemic cardiomyopathy: Clinical outcomes after a single endocardial ablation","volume":"31","author":"Suzuki","year":"2015","unstructured":"11. Suzuki A, Yoshida A, Takei A, et al. Prophylactic catheter ablation of ventricular tachycardia before cardioverter-defibrillator implantation in patients with non-ischemic cardiomyopathy: Clinical outcomes after a single endocardial ablation. J Arrhythm 2015;31:122-9.","journal-title":"J Arrhythm"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1111\/jce.12825","article-title":"Impact of substrate-based ablation of ventricular tachycardia on cardiac mortality in patients with implantable cardioverter-defibrillators","volume":"26","author":"Komatsu","year":"2015","unstructured":"12. Komatsu Y, Maury P, Sacher F, et al. Impact of substrate-based ablation of ventricular tachycardia on cardiac mortality in patients with implantable cardioverter-defibrillators. J Cardiovasc Electrophysiol 2015;26:1230-8.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/jce.12567","article-title":"Catheter ablation for ventricular tachycardia in patients with an implantable cardioverter defibrillator (CALYPSO) pilot trial","volume":"26","author":"Al-Khatib","year":"2015","unstructured":"13. Al-Khatib SM, Daubert JP, Anstrom KJ, et al. Catheter ablation for ventricular tachycardia in patients with an implantable cardioverter defibrillator (CALYPSO) pilot trial. J Cardiovasc Electrophysiol 2015;26:151-7.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.hrthm.2013.12.014","article-title":"Patients treated with catheter ablation for ventricular tachycardia after an ICD shock have lower long-term rates of death and heart failure hospitalization than do patients treated with medical management only","volume":"11","author":"Bunch","year":"2014","unstructured":"14. Bunch TJ, Weiss JP, Crandall BG, et al. Patients treated with catheter ablation for ventricular tachycardia after an ICD shock have lower long-term rates of death and heart failure hospitalization than do patients treated with medical management only. Heart Rhythm 2014;11:533-40.","journal-title":"Heart Rhythm"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(09)61755-4","article-title":"Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial","volume":"375","author":"Kuck","year":"2010","unstructured":"15. Kuck KH, Schaumann A, Eckardt L, et al. Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial. Lancet 2010;375:31-40.","journal-title":"Lancet"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Kuck KH, Tilz RR, Deneke T, et al. Impact of substrate modification by catheter ablation on implantable cardioverter-defibrillator interventions in patients with unstable ventricular arrhythmias and coronary artery disease: results From the Multicenter Randomized Controlled SMS (Substrate Modification Study). Circ Arrhythm Electrophysiol 2017;10:e004422.","DOI":"10.1161\/CIRCEP.116.004422"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Reddy VY, Reynolds MR, Neuzil P, et al. Prophylactic catheter ablation for the prevention of defibrillator therapy. N Engl J Med 2007;357;2657-65.","DOI":"10.1056\/NEJMoa065457"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1161\/01.CIR.88.3.915","article-title":"'Zigzag' course of activation","volume":"88","author":"de Bakker","year":"1993","unstructured":"18. de Bakker JM, van Capelle FJ, Janse MJ, et al. Slow conduction in the infarcted human heart. 'Zigzag' course of activation. Circulation 1993;88:915-26.","journal-title":"Circulation"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/pace.12827","article-title":"A historical perspective on the role of functional lines of block in the re-entrant circuit of ventricular tachycardia","volume":"39","author":"Proietti","year":"2016","unstructured":"19. Proietti R, Roux JF, Verma A, et al. A historical perspective on the role of functional lines of block in the re-entrant circuit of ventricular tachycardia. Pacing Clin Electrophysiol 2016;39:490-6.","journal-title":"Pacing Clin Electrophysiol"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. El-Sherif N. Electrophysiologic mechanisms of ventricular arrhythmias. Int J Card Imaging 1991;7;141-50.","DOI":"10.1007\/BF01797747"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators. A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. N Engl J Med 1997;337:1576-83.","DOI":"10.1056\/NEJM199711273372202"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1056\/NEJMoa013474","article-title":"Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction","volume":"346","author":"Moss","year":"2002","unstructured":"22. Moss AJ, Zareba W, Hall WJ, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 2002;346:877-83.","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"282","DOI":"10.15420\/aer.2018.36.3","article-title":"Identifying risk and management of acute haemodynamic decompensation during catheter ablation of ventricular tachycardia","volume":"7","author":"Muser","year":"2018","unstructured":"23. Muser D, Castro SA, Liang JJ, Santangeli P. Identifying risk and management of acute haemodynamic decompensation during catheter ablation of ventricular tachycardia. Arrhythm Electrophysiol Rev 2018;7:282-7.","journal-title":"Arrhythm Electrophysiol Rev"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s10840-018-0376-5","article-title":"Prophylactic catheter ablation of ventricular tachycardia in ischemic cardiomyopathy: a systematic review and meta-analysis of randomized controlled trials","volume":"53","author":"Atti","year":"2018","unstructured":"24. Atti V, Vuddanda V, Turagam MK, et al. Prophylactic catheter ablation of ventricular tachycardia in ischemic cardiomyopathy: a systematic review and meta-analysis of randomized controlled trials. J Interv Card Electrophysiol 2018;53:207-15.","journal-title":"J Interv Card Electrophysiol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jacc.2012.03.044","article-title":"Endo-epicardial homogenization of the scar versus limited substrate ablation for the treatment of electrical storms in patients with ischemic cardiomyopathy","volume":"60","author":"Di Biase","year":"2012","unstructured":"25. Di Biase L, Santangeli P, Burkhardt DJ, et al. Endo-epicardial homogenization of the scar versus limited substrate ablation for the treatment of electrical storms in patients with ischemic cardiomyopathy. J Am Coll Cardiol 2012;60:132-41.","journal-title":"J Am Coll Cardiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1161\/CIRCULATIONAHA.111.043216","article-title":"Elimination of local abnormal ventricular activities: a new end point for substrate modification in patients with scar-related ventricular tachycardia","volume":"125","author":"Jais","year":"2012","unstructured":"26. Jais P, Maury P, Khairy P, et al. Elimination of local abnormal ventricular activities: a new end point for substrate modification in patients with scar-related ventricular tachycardia. Circulation 2012;125:2184-96.","journal-title":"Circulation"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1093\/europace\/eut419","article-title":"Electrical isolation of a substrate after myocardial infarction: a novel ablation strategy for unmappable ventricular tachycardias - feasibility and clinical outcome","volume":"16","author":"Tilz","year":"2014","unstructured":"27. Tilz RR, Makimoto H, Lin T, et al. Electrical isolation of a substrate after myocardial infarction: a novel ablation strategy for unmappable ventricular tachycardias - feasibility and clinical outcome. Europace 2014;16:1040-52.","journal-title":"Europace"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/j.1540-8167.2011.02246.x","article-title":"Late potentials abolition as an additional technique for reduction of arrhythmia recurrence in scar related ventricular tachycardia ablation","volume":"23","author":"Vergara","year":"2012","unstructured":"28. Vergara P, Trevisi N, Ricco A, et al. Late potentials abolition as an additional technique for reduction of arrhythmia recurrence in scar related ventricular tachycardia ablation. J Cardiovasc Electrophysiol 2012;23:621-27.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1113\/JP270534","article-title":"Therapy for ventricular arrhythmias in structural heart disease: a multifaceted challenge","volume":"594","author":"Proietti","year":"2016","unstructured":"29. Proietti R, Joza J, Essebag V. Therapy for ventricular arrhythmias in structural heart disease: a multifaceted challenge. J Physiol 2016;594:2431-43.","journal-title":"J Physiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/europace\/euu326","article-title":"Substrate-guided ablation of haemodynamically tolerated and untolerated ventricular tachycardia in patients with structural heart disease: effect of cardiomyopathy type and acute success on long-term outcome","volume":"17","author":"Proietti","year":"2015","unstructured":"30. Proietti R, Essebag V, Beardsall J, et al. Substrate-guided ablation of haemodynamically tolerated and untolerated ventricular tachycardia in patients with structural heart disease: effect of cardiomyopathy type and acute success on long-term outcome. Europace 2015;17:461-7.","journal-title":"Europace"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/HCO.0000000000000242","article-title":"Recent advances in ablation of ventricular tachycardia associated with structural heart disease: overcoming the challenges of functional and fixed barriers","volume":"31","author":"Proietti","year":"2016","unstructured":"31. Proietti R, Roux JF, Essebag V. Recent advances in ablation of ventricular tachycardia associated with structural heart disease: overcoming the challenges of functional and fixed barriers. 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