{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T22:15:09Z","timestamp":1775513709983,"version":"3.50.1"},"reference-count":54,"publisher":"Radcliffe Medical Media Ltd","issue":"1","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arrhythm Electrophysiol Rev"],"published-print":{"date-parts":[[2021,4,12]]},"abstract":"<p>Mitral valve prolapse (MVP) is the most common valvular heart disease, affecting 2\u20133% of the general population. Barlow\u2019s disease is a clinical syndrome characterised by MVP. Initially thought a benign condition, MVP is now recognised as a cause of sudden cardiac death and ventricular arrhythmias. The development of new imaging techniques has contributed recently to the identification of novel risk factors. Catheter ablation of ventricular arrhythmias in patients affected by MVP is traditionally considered challenging. In this review, the authors summarise the evidence on arrhythmogenesis in the context of MVP, along with risk stratification of sudden cardiac death and the available treatment options, including new catheter ablation techniques.<\/p>","DOI":"10.15420\/aer.2020.29","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T13:13:44Z","timestamp":1619183624000},"page":"33-37","source":"Crossref","is-referenced-by-count":12,"title":["Electrophysiological Substrate in Patients with Barlow\u2019s Disease"],"prefix":"10.15420","volume":"10","author":[{"given":"Pasquale","family":"Vergara","sequence":"first","affiliation":[{"name":"Arrhythmia Unit and Electrophysiology Laboratories, IRCCS San Raffaele Scientific Institute, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savino","family":"Altizio","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit and Electrophysiology Laboratories, IRCCS San Raffaele Scientific Institute, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Falasconi","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit and Electrophysiology Laboratories, IRCCS San Raffaele Scientific Institute, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Pannone","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit and Electrophysiology Laboratories, IRCCS San Raffaele Scientific Institute, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Gulletta","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit and Electrophysiology Laboratories, IRCCS San Raffaele Scientific Institute, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo Della","family":"Bella","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit and Electrophysiology Laboratories, IRCCS San Raffaele Scientific Institute, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6096","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1056\/NEJM199907013410101","article-title":"Prevalence and clinical outcome of mitral-valve prolapse","volume":"341","author":"Freed","year":"1999","unstructured":"1. 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