{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:04:45Z","timestamp":1784019885751,"version":"3.55.0"},"reference-count":22,"publisher":"Radcliffe Medical Media Ltd","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arrhythm Electrophysiol Rev"],"abstract":"<jats:p>Objectives: The occurrence of new conduction abnormalities necessitating permanent pacemaker implantation (PPI) is a complication of transcatheter aortic valve replacement (TAVR). Previous studies have shown inconsistent results about the clinical impact of new PPI after TAVR. Methods: CONDUCT was a prospective observational registry that enrolled 295 patients undergoing TAVR at four European centres. The primary goal of this registry was to compare 1-year clinical outcomes in TAVR patients with or without PPI, using one-to-four propensity score matched (PSM) analysis. It also assessed major adverse cardiac events (MACE) in patients undergoing right ventricular pacing after PPI. Results: Out of 160 PSM patients, 36 underwent PPI and the other 124 had no PPI within 30 days post-TAVR. The median age of the patients was 80 years, with more men (80.6% and 84.7% in patients with and without PPI, respectively) and similar EuroSCORE II and Society of Thoracic Surgeons scores. Patients with PPI had higher diabetes prevalence (p=0.055) and lower left ventricular ejection fraction percentages (p=0.034), but higher systolic pulmonary artery pressure (p=0.013) than those without PPI. However, these differences diminished after PSM. At 1 year, PPI patients had a non-significant but slightly higher incidence of MACE (22.2% versus 13.7%; p=0.216) (HR 1.63; 95% CI [0.72\u20133.71]) driven by increased heart failure (11.1% versus 2.4%; p=0.046) (HR 5.05; 95% CI [1.09\u201323.4]). Freedom from all-cause mortality, cardiovascular death, stroke and endocarditis at 1-year follow-up was comparable between groups. Conclusion: Despite a higher incidence of congestive heart failure rehospitalisation in patients undergoing PPI, 1-year clinical outcomes were similar in both groups.<\/jats:p>","DOI":"10.15420\/aer.2024.52","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:01:16Z","timestamp":1750849276000},"source":"Crossref","is-referenced-by-count":1,"title":["One-year Outcomes of Permanent Pacemaker Implantation after Transcatheter Aortic Valve Replacement: CONDUCT Registry: A Propensity Score-Matched Comparison"],"prefix":"10.15420","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5807-7615","authenticated-orcid":false,"given":"Michal","family":"Droppa","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-6038","authenticated-orcid":false,"given":"Tobias","family":"Geisler","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-1163","authenticated-orcid":false,"given":"Jan","family":"Baan","sequence":"additional","affiliation":[{"name":"Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3633-0549","authenticated-orcid":false,"given":"Niels-Erik","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Link\u00f6ping University Hospital, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Baranowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Link\u00f6ping University Hospital, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-2919","authenticated-orcid":false,"given":"Wilbert","family":"Wesselink","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4704-0499","authenticated-orcid":false,"given":"Jana","family":"Kurucova","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-8006","authenticated-orcid":false,"given":"Luis","family":"Hack","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0915-427X","authenticated-orcid":false,"given":"Anjaly","family":"Vijayan","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Preventive Medicine, Cloppenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-2110","authenticated-orcid":false,"given":"Peter","family":"Bramlage","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology and Preventive Medicine, Cloppenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-7476","authenticated-orcid":false,"given":"Tanja K","family":"Rudolph","sequence":"additional","affiliation":[{"name":"General and Interventional Cardiology\/Angiology, Heart and Diabetes Centre, Ruhr University, Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Smith CR, Leon MB, Mack MJ, et al. 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Circ Cardiovasc Interv 2016;9:e003635. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.115.003635; PMID:\u00a027169577.","DOI":"10.1161\/circinterventions.115.003635"}],"container-title":["Arrhythmia &amp; Electrophysiology Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aerjournal.com\/articleindex\/aer.2024.52","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:01:18Z","timestamp":1750849278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerjournal.com\/articleindex\/aer.2024.52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":22,"URL":"https:\/\/doi.org\/10.15420\/aer.2024.52","relation":{},"ISSN":["2050-3377","2050-3369"],"issn-type":[{"value":"2050-3377","type":"electronic"},{"value":"2050-3369","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,24]]},"article-number":"e14"}}