{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:06:52Z","timestamp":1785150412600,"version":"3.55.0"},"reference-count":20,"publisher":"Radcliffe Medical Media Ltd","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Non-invasive ablation of cardiac tissue to control ventricular tachycardia (VT) is a novel therapeutic consideration in the management of ventricular arrhythmias associated with structural heart disease. The technique involves the use of stereotactic radiotherapy delivered to VT substrates. Although invasive mapping can be used to identify the target, the use of non-invasive ECG and imaging techniques combined with multi-electrode body-surface ECG recordings offers the potential of a completely non-invasive approach. Early case series have demonstrated a consistent decrease in VT burden and sufficient early safety to allow more detailed multicenter studies. Such studies are currently in progress to further evaluate this promising technology.<\/jats:p>","DOI":"10.15420\/aer.7.1.eo1","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T13:22:07Z","timestamp":1520947327000},"page":"8","source":"Crossref","is-referenced-by-count":22,"title":["Non-invasive Cardiac Radiation for Ablation of Ventricular Tachycardia: a New Therapeutic Paradigm in Electrophysiology"],"prefix":"10.15420","volume":"7","author":[{"given":"Eun-Jeong","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Davogustto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy M","family":"John","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1056\/NEJMe1713245","article-title":"Noninvasive ablation of ventricular tachycardia","volume":"377","author":"RM","year":"2017","unstructured":"1. John RM, Stevenson WG. Noninvasive ablation of ventricular tachycardia. N Engl J Med 2017;377:2388-90.","journal-title":"N Engl J Med"},{"key":"ref1","unstructured":"2. Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Heart Rhythm 2017;"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1161\/hc0502.103330","article-title":"Quality of life in the antiarrhythmics versus implantable defibrillators trial: impact of therapy and influence of adverse symptoms and defibrillator shocks","volume":"105","author":"Schron","year":"2002","unstructured":"3. Schron EB, Exner DV, Yao Q, et al. Quality of life in the antiarrhythmics versus implantable defibrillators trial: impact of therapy and influence of adverse symptoms and defibrillator shocks. Circulation 2002;105:589-94.","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ahj.2017.03.009","article-title":"Effects of implantable cardioverter\/defibrillator shock and antitachycardia pacing on anxiety and quality of life: a MADIT-RIT substudy","volume":"189","author":"Perini","year":"2017","unstructured":"4. Perini AP, Kutyifa V, Veazie P, et al. Effects of implantable cardioverter\/defibrillator shock and antitachycardia pacing on anxiety and quality of life: a MADIT-RIT substudy. Am Heart J 2017;189:75-84.","journal-title":"Am Heart J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1056\/NEJMoa071098","article-title":"Prognostic importance of defibrillator shocks in patients with heart failure","volume":"359","author":"Poole","year":"2008","unstructured":"5. Poole JE, Johnson GW, Hellkamp AS, et al. Prognostic importance of defibrillator shocks in patients with heart failure. N Engl J Med 2008;359:1009-17.","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1056\/NEJMoa1513614","article-title":"Ventricular tachycardia ablation versus escalation of antiarrhythmic drugs","volume":"375","author":"Sapp","year":"2016","unstructured":"6. Sapp JL, Wells GA, Parkash R, et al. Ventricular tachycardia ablation versus escalation of antiarrhythmic drugs. N Engl J Med 2016;375:111-21.","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1056\/NEJMoa1613773","article-title":"Noninvasive cardiac radiation for ablation of ventricular tachycardia","volume":"377","author":"Cuculich","year":"2017","unstructured":"7. Cuculich PS, Schill MR, Kashani R, et al. Noninvasive cardiac radiation for ablation of ventricular tachycardia. N Engl J Med 2017;377:2325-36.","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ijrobp.2009.09.042","article-title":"American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guideline for the performance of stereotactic body radiation therapy","volume":"76","author":"Potters","year":"2010","unstructured":"8. Potters L, Kavanagh B, Galvin JM, et al.; American Society for Therapeutic Radiology and Oncology; American College of Radiology. American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guideline for the performance of stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys 2010;76:326-32.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref8","unstructured":"9. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand 1951;102:316-9."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1200\/JCO.2014.55.4675","article-title":"Emergence of stereotactic body radiation therapy and its impact on current and future clinical practice","volume":"32","author":"Timmerman","year":"2014","unstructured":"10. Timmerman RD, Herman J, Cho LC. Emergence of stereotactic body radiation therapy and its impact on current and future clinical practice. J Clin Oncol 2014;32:2847-54.","journal-title":"J Clin Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3109\/02841869409121782","article-title":"Methodological aspects","volume":"33","author":"Lax","year":"1994","unstructured":"11. Lax I, Blomgren H, N\u00e4slund I, Svanstr\u00f6m R. Stereotactic radiotherapy of malignancies in the abdomen. Methodological aspects. Acta Oncol 1994;33:677-83.","journal-title":"Acta Oncol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1200\/JCO.2006.09.7469","article-title":"Stereotactic body radiation therapy in multiple organ sites","volume":"25","author":"Timmerman","year":"2007","unstructured":"12. Timmerman RD, Kavanagh BD, Cho LC, et al. Stereotactic body radiation therapy in multiple organ sites. J Clin Oncol 2007;25:947-52.","journal-title":"J Clin Oncol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2016.11.005","article-title":"Stereotactic ablative body radiosurgery (SABR) or stereotactic body radiation therapy (SBRT)","volume":"109","author":"MR","year":"2017","unstructured":"13. Folkert MR, Timmerman RD. Stereotactic ablative body radiosurgery (SABR) or stereotactic body radiation therapy (SBRT). Adv Drug Deliv Rev 2017;109:3-14.","journal-title":"Adv Drug Deliv Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.hrthm.2010.02.010","article-title":"Noninvasive stereotactic radiosurgery (CyberHeart) for creation of ablation lesions in the atrium","volume":"7","author":"Sharma","year":"2010","unstructured":"14. Sharma A, Wong D, Weidlich G, et al. Noninvasive stereotactic radiosurgery (CyberHeart) for creation of ablation lesions in the atrium. Heart Rhythm 2010;7:802-10.","journal-title":"Heart Rhythm"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.hrthm.2009.04.030","article-title":"EHRA\/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias: developed in a partnership with the European Heart Rhythm Association (EHRA), a Registered Branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society (HRS); in collaboration with the American College of Cardiology (ACC) and the American Heart Association (AHA)","volume":"6","author":"Aliot","year":"2009","unstructured":"15. Aliot EM, Stevenson WG, Almendral-Garrote JM, et al. EHRA\/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias: developed in a partnership with the European Heart Rhythm Association (EHRA), a Registered Branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society (HRS); in collaboration with the American College of Cardiology (ACC) and the American Heart Association (AHA). Heart Rhythm 2009;6:886-933.","journal-title":"Heart Rhythm"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/j.jacc.2011.07.029","article-title":"The electrophysiological cardiac ventricular substrate in patients after myocardial infarction: noninvasive characterization with electrocardiographic imaging","volume":"58","author":"Cuculich","year":"2011","unstructured":"16. Cuculich PS, Zhang J, Wang Y, et al. The electrophysiological cardiac ventricular substrate in patients after myocardial infarction: noninvasive characterization with electrocardiographic imaging. J Am Coll Cardiol 2011;58:1893- 902.","journal-title":"J Am Coll Cardiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1161\/01.RES.46.2.283","article-title":"A comparison of volume conductor and source geometry effects on body surface and epicardial potentials","volume":"46","author":"Rudy","year":"1980","unstructured":"17. Rudy Y, Plonsey R. A comparison of volume conductor and source geometry effects on body surface and epicardial potentials. Circ Res 1980;46:283-91.","journal-title":"Circ Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1161\/CIRCEP.115.002765","article-title":"Stereotactic ablative radiotherapy for the treatment of refractory cardiac ventricular arrhythmia","volume":"8","author":"BW Jr","year":"2015","unstructured":"18. Loo BW Jr, Soltys SG, Wang L, et al. Stereotactic ablative radiotherapy for the treatment of refractory cardiac ventricular arrhythmia. Circ Arrhythm Electrophysiol 2015;8: 748-50.","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s11886-017-0886-2","article-title":"Ablative radiotherapy as a noninvasive alternative to catheter ablation for cardiac arrhythmias","volume":"19","author":"PC","year":"2017","unstructured":"19. Zei PC, Soltys S. Ablative radiotherapy as a noninvasive alternative to catheter ablation for cardiac arrhythmias. Curr Cardiol Rep 2017;19:79.","journal-title":"Curr Cardiol Rep"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"317659","DOI":"10.4061\/2011\/317659","article-title":"Radiation-induced heart disease: a clinical update","volume":"2011","author":"Yusuf","year":"2011","unstructured":"20. Yusuf SW, Sami S, Daher IN. Radiation-induced heart disease: a clinical update. Cardiol Res Pract 2011;2011:317659.","journal-title":"Cardiol Res Pract"}],"container-title":["Arrhythmia &amp; Electrophysiology Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aerjournal.com\/articles\/non-invasive-cardiac-radiation-ablation-ventricular-tachycardia-new-therapeutic-paradigm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T15:48:16Z","timestamp":1599752896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aerjournal.com\/articles\/non-invasive-cardiac-radiation-ablation-ventricular-tachycardia-new-therapeutic-paradigm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"alternative-id":["aer.7.1.EO1"],"URL":"https:\/\/doi.org\/10.15420\/aer.7.1.eo1","relation":{},"ISSN":["2050-3369"],"issn-type":[{"value":"2050-3369","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}