{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:32:21Z","timestamp":1775147541308,"version":"3.50.1"},"reference-count":63,"publisher":"Radcliffe Medical Media Ltd","issue":"1","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Card Fail Rev"],"published-print":{"date-parts":[[2019,2,11]]},"abstract":"<jats:p>Congestion is the predominant cause of more than 1 million annual heart failure hospitalisations and recurrent fluid overload predicts poor outcomes. Unresolved congestion trumps serum creatinine increases in predicting adverse heart failure outcomes. No pharmacological approach for acute heart failure has reduced these deleterious consequences. Simplified ultrafiltration devices permit fluid removal in lower acuity hospital settings, but results regarding safety and efficacy have been variable. However, adjustment of ultrafiltration rates to patients\u2019 vital signs and renal function has been associated with more effective decongestion and fewer heart failure events. Many aspects of ultrafiltration, including patient selection, fluid removal rates, venous access, prevention of therapy- related complications and costs, require further investigation.<\/jats:p>","DOI":"10.15420\/cfr.2018.29.2","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T15:14:51Z","timestamp":1550762091000},"page":"9-18","source":"Crossref","is-referenced-by-count":23,"title":["Ultrafiltration in Acute Heart Failure"],"prefix":"10.15420","volume":"5","author":[{"given":"Maria Rosa","family":"Costanzo","sequence":"first","affiliation":[{"name":"Advocate Heart Institute, Naperville, Illinois, US"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6096","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries","DOI":"10.1016\/j.jacc.2013.11.053"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions","DOI":"10.1002\/ejhf.566"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Repeated hospitalizations predict mortality in the community population with heart failure","DOI":"10.1016\/j.ahj.2007.01.041"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Impaired natriuretic and renal endocrine response to acute volume expansion in pre-clinical systolic and diastolic dysfunction","DOI":"10.1016\/j.jacc.2011.07.042"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Cardiac troponin and outcome in acute heart failure","DOI":"10.1056\/NEJMoa0706824"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Global myocardial oedema in advanced decompensated heart failure","DOI":"10.1093\/ehjci\/jew131"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"The kidney in congestive heart failure: 'are natriuresis, sodium, and diuretics really the good, the bad and the ugly?'","DOI":"10.1002\/ejhf.35"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Systemic arterial and venous determinants of renal hemodynamics in congestive heart failure","DOI":"10.1007\/s10741-011-9246-2"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Cardiorenal syndrome","DOI":"10.1016\/j.jacc.2008.07.051"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. 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