{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:55:42Z","timestamp":1789541742848,"version":"build-2803163510"},"reference-count":31,"publisher":"Radcliffe Medical Media Ltd","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM007569"],"award-info":[{"award-number":["GM007569"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL166960"],"award-info":[{"award-number":["K23HL166960"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["929347"],"award-info":[{"award-number":["929347"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008868","name":"International Society for Heart and Lung Transplantation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Card Fail Rev"],"abstract":"<jats:p>Introduction: Percutaneous ventricular assist devices (pVADs) are increasingly used in cardiogenic shock but are associated with complications including haemolysis. The aim of this study was to investigate patient characteristics associated with haemolysis in cardiogenic shock patient population. Methods: Consecutive patients were identified using Current Procedural Terminology (CPT) codes for pVAD insertion. Patient characteristics, laboratory and imaging data, and patient outcomes were abstracted manually and using validated automated methods. Laboratory-defined haemolysis required a drop in haemoglobin \u22652\u00a0mg\/dl with either lactate dehydrogenase \u2265250\u00a0units\/l or undetectable haptoglobin. Clinically significant haemolysis was defined as laboratory-defined haemolysis necessitating transfusion. Primary outcome was the association between haemolysis and on-device and 30-day mortality. Results: A total of 196 patients underwent pVAD insertion for cardiogenic shock during the study period and were included. Laboratory-defined haemolysis occurred in 46 patients (23.5%), of whom 12 (6.1%) had clinically significant haemolysis. Haemolysis occurred more often following emergency insertion, rather than elective insertion (84.8% versus 40.0%, p&lt;0.001) in patients with elevated lactic acid levels (median 2.5 versus 1.6, p=0.016) and elevated heart rates (92.5\u00a0BPM versus 86.5\u00a0BPM, p=0.023). After multivariable adjustment, there was no association between laboratory-defined haemolysis and on-device (OR 0.6; 95% CI [0.1\u20133.4]; p=0.565) or 30-day mortality (OR 2.1; 95% CI [0.4\u201313.0]; p=0.391). Conclusion: Laboratory-defined haemolysis was common in patients with cardiogenic shock and pVAD, but clinically significant haemolysis was not. There was no association between haemolysis and on-device or 30-day mortality.<\/jats:p>","DOI":"10.15420\/cfr.2024.30","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:52:10Z","timestamp":1740048730000},"source":"Crossref","is-referenced-by-count":1,"title":["Patient-specific Predictors of Haemolysis with Percutaneous Ventricular Assist Devices"],"prefix":"10.15420","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-0055","authenticated-orcid":false,"given":"Alexander E","family":"Sullivan","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7983-5910","authenticated-orcid":false,"given":"Hannah","family":"Granger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-6050","authenticated-orcid":false,"given":"Leonie","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Napper","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4691-7087","authenticated-orcid":false,"given":"Lena","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Lukas","family":"Laws","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-0313","authenticated-orcid":false,"given":"Quinn S","family":"Wells","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-3796","authenticated-orcid":false,"given":"Eric","family":"Farber-Eger","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-1761","authenticated-orcid":false,"given":"Bret D","family":"Alvis","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Vanderbilt University Medical Center, Nashville, TN, US; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8764-2548","authenticated-orcid":false,"given":"Jared M","family":"O\u2019Leary","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8008-8086","authenticated-orcid":false,"given":"Swaroop","family":"Bommareddi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3379-5834","authenticated-orcid":false,"given":"Kaushik V","family":"Amancherla","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3778-9979","authenticated-orcid":false,"given":"Aniket S","family":"Rali","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN, US; Department of Anaesthesiology, Vanderbilt University Medical Center, Nashville, TN, US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Amin AP, Spertus JA, Curtis JP, et al. 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Management of bleeding and hemolysis during percutaneous microaxial flow pump support: a practical approach. JACC Cardiovasc Interv 2023;16:1707\u201320. https:\/\/doi.org\/10.1016\/j.jcin.2023.05.043; PMID:\u00a037495347.","DOI":"10.1016\/j.jcin.2023.05.043"},{"key":"ref11","unstructured":"Siddiqi HK, Trahanas J, Xu M, et al. Outcomes of heart transplant donation after circulatory death. J Am Coll Cardiol 2023;82:1512\u201320. https:\/\/doi.org\/10.1016\/j.jacc.2023.08.006; PMID:\u00a037793748."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Beckman JA, Duncan MS, Damrauer SM, et al. Microvascular disease, peripheral artery disease, and amputation. Circulation 2019;140:449\u201358. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.040672; PMID:\u00a031280589.","DOI":"10.1161\/CIRCULATIONAHA.119.040672"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Davogustto GE, Clark DE, Hardison E, et al. Characteristics associated with multisystem inflammatory syndrome among adults with SARS-CoV-2 infection. JAMA Netw Open 2021;4:e2110323. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.10323; PMID:\u00a034009351.","DOI":"10.1001\/jamanetworkopen.2021.10323"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Bielinski SJ, Pathak J, Carrell DS, et al. A robust e-epidemiology tool in phenotyping heart failure with differentiation for preserved and reduced ejection fraction: the electronic medical records and genomics (eMERGE) network. J Cardiovasc Transl Res 2015;8:475\u201383. https:\/\/doi.org\/10.1007\/s12265-015-9644-2; PMID:\u00a026195183.","DOI":"10.1007\/s12265-015-9644-2"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Shuey MM, Stead WW, Aka I, et al. Next-generation phenotyping: introducing phecodeX for enhanced discovery research in medical phenomics. 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Increased plasma-free hemoglobin levels identify hemolysis in patients with cardiogenic shock and a trans valvular micro-axial flow pump. Artif Organs 2019;43:125\u201331. https:\/\/doi.org\/10.1111\/aor.13319; PMID:\u00a030216467.","DOI":"10.1111\/aor.13319"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Zaiser AS, Fahrni G, Hollinger A, et al. Adverse events of percutaneous microaxial left ventricular assist devices: a retrospective, single-centre cohort study. J Clin Med 2021;10:3710. https:\/\/doi.org\/10.3390\/jcm10163710; PMID:\u00a034442010.","DOI":"10.3390\/jcm10163710"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Badiye AP, Hernandez GA, Novoa I, Chaparro SV. Incidence of hemolysis in patients with cardiogenic shock treated with Impella percutaneous left ventricular assist device. ASAIO J 2016;62:11\u201314. https:\/\/doi.org\/10.1097\/MAT.0000000000000290; PMID:\u00a026418208.","DOI":"10.1097\/mat.0000000000000290"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Papanastasiou CA, Kyriakoulis KG, Theochari CA, et al. Comprehensive review of hemolysis in ventricular assist devices. World J Cardiol 2020;12:334\u201341. https:\/\/doi.org\/10.4330\/wjc.v12.i7.334; PMID:\u00a032843935.","DOI":"10.4330\/wjc.v12.i7.334"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Zhang H, Kang K, Chen S, et al. High serum lactate dehydrogenase as a predictor of cardiac insufficiency at follow-up in elderly patients with acute myocardial infarction. Arch Gerontol Geriatr 2024;117:105253. https:\/\/doi.org\/10.1016\/j.archger.2023.105253; PMID:\u00a037956585.","DOI":"10.1016\/j.archger.2023.105253"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Reis GJ, Kaufman HW, Horowitz GL, Pasternak RC. Usefulness of lactate dehydrogenase and lactate dehydrogenase isoenzymes for diagnosis of acute myocardial infarction. Am J Cardiol 1988;61:754\u20138. https:\/\/doi.org\/10.1016\/0002-9149(88)91061-2; PMID:\u00a03354438.","DOI":"10.1016\/0002-9149(88)91061-2"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Akasha R, Amanullah M, Ali SP, et al. Assessment of acute myocardial infarction by the use of special biochemical markers. Ulutas Med J 2015;1:68\u221273. http:\/\/doi.org\/10.5455\/umj.20150416122936.","DOI":"10.5455\/umj.20150416122936"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"K\u00f6rm\u00f6czi GF, S\u00e4emann MD, Buchta C, et al. Influence of clinical factors on the haemolysis marker haptoglobin. Eur J Clin Invest 2006;36:202\u20139. https:\/\/doi.org\/10.1111\/j.1365-2362.2006.01617.x; PMID:\u00a016506966.","DOI":"10.1111\/j.1365-2362.2006.01617.x"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Roberts N, Chandrasekaran U, Das S, et al. Hemolysis associated with Impella heart pump positioning: in vitro hemolysis testing and computational fluid dynamics modeling. Int J Artif Organs 2020;43:391398820909843. https:\/\/doi.org\/10.1177\/0391398820909843; PMID:\u00a032126866.","DOI":"10.1177\/0391398820909843"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Cannata A, Cantoni S, Sciortino A, et al. Mechanical hemolysis complicating transcatheter interventions for valvular heart disease: JACC state-of-the-art review. J Am Coll Cardiol 2021;77:2323\u201334. https:\/\/doi.org\/10.1016\/j.jacc.2021.03.295; PMID:\u00a033958130.","DOI":"10.1016\/j.jacc.2021.03.295"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Panoulas V, Monteagudo-Vela M. Predictors of short-term survival in cardiogenic shock patients requiring left ventricular support using the Impella CP or 5.0. CJC Open 2021;3:1002\u20139. https:\/\/doi.org\/10.1016\/j.cjco.2021.03.008; PMID:\u00a034505039.","DOI":"10.1016\/j.cjco.2021.03.008"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Van Avondt K, Nur E, Zeerleder S. Mechanisms of haemolysis-induced kidney injury. Nat Rev Nephrol 2019;15:671\u201392. https:\/\/doi.org\/10.1038\/s41581-019-0181-0; PMID:\u00a031455889.","DOI":"10.1038\/s41581-019-0181-0"},{"key":"ref30","unstructured":"M\u00f8ller JE, Engstr\u00f8m T, Jensen LO, et al. Microaxial flow pump or standard care in infarct-related cardiogenic shock. N Engl J Med 2024;390:1382\u201393. https:\/\/doi.org\/10.1056\/NEJMoa2312572; PMID:\u00a038587239."}],"container-title":["Cardiac Failure Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cfrjournal.com\/articleindex\/cfr.2024.30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:52:19Z","timestamp":1740048739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cfrjournal.com\/articleindex\/cfr.2024.30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":31,"URL":"https:\/\/doi.org\/10.15420\/cfr.2024.30","relation":{},"ISSN":["2057-7559","2057-7540"],"issn-type":[{"value":"2057-7559","type":"electronic"},{"value":"2057-7540","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"article-number":"e04"}}