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Phrenic nerve stimulation, particularly through devices such as the remed\u0113 System, represents a novel, evidence-based therapeutic avenue for patients with moderate to severe CSA. This review provides a comprehensive overview of CSA, explores the underlying pathophysiology, evaluates conventional treatments, and examines the mechanisms, efficacy and limitations of phrenic nerve stimulation based on current literature.<\/jats:p>","DOI":"10.15420\/cfr.2025.32","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:07:17Z","timestamp":1766056037000},"source":"Crossref","is-referenced-by-count":0,"title":["Phrenic Nerve Stimulation for Central Sleep Apnoea: When and Why?"],"prefix":"10.15420","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5061-7493","authenticated-orcid":false,"given":"Jonathan","family":"Na","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027zt9171","id-type":"ROR","asserted-by":"publisher"}],"name":"Houston Methodist"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-1684","authenticated-orcid":false,"given":"Miguel","family":"Valderrabano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027zt9171","id-type":"ROR","asserted-by":"publisher"}],"name":"Houston Methodist"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-8014","authenticated-orcid":false,"given":"Paul","family":"Schurmann","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027zt9171","id-type":"ROR","asserted-by":"publisher"}],"name":"Houston Methodist"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Eckert DJ, Jordan AS, Merchia P, Malhotra A. 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