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In recent years, novel phenotyping approaches based on the concept of sequential cardiac chamber involvement have been developed for other cardiovascular conditions, including mitral regurgitation, aortic stenosis, and heart failure with preserved ejection fraction. Similarly, the development of an extra-valvular echocardiographic staging system for mitral stenosis, grounded in the extent of cardiac chamber involvement, appears warranted to improve risk stratification and tailor clinical management.<\/jats:p>","DOI":"10.15420\/ecr.2026.05","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:34:30Z","timestamp":1783535670000},"source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Valve Itself: Extra-valvular Phenotyping in Mitral Stenosis: A\u00a0Novel Pathophysiology-driven Echocardiographic Staging System"],"prefix":"10.15420","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5192-6280","authenticated-orcid":false,"given":"Gabriele","family":"Cordoni","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04m6sq715","id-type":"ROR","asserted-by":"publisher"}],"name":"H\u00f4pital Arnaud de Villeneuve"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7160-2506","authenticated-orcid":false,"given":"Dania","family":"Mohty","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cdrtq48","id-type":"ROR","asserted-by":"publisher"}],"name":"Alfaisal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-0350","authenticated-orcid":false,"given":"Anastasia","family":"Shchendrygina","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02yqqv993","id-type":"ROR","asserted-by":"publisher"}],"name":"Sechenov University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-3815","authenticated-orcid":false,"given":"Domenico","family":"Galzerano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cdrtq48","id-type":"ROR","asserted-by":"publisher"}],"name":"Alfaisal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Al Sergani","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cdrtq48","id-type":"ROR","asserted-by":"publisher"}],"name":"Alfaisal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-0113","authenticated-orcid":false,"given":"Giovanni","family":"Di Salvo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cdrtq48","id-type":"ROR","asserted-by":"publisher"}],"name":"Alfaisal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3317-7342","authenticated-orcid":false,"given":"Valeria","family":"Pergola","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05n0wgt02","id-type":"ROR","asserted-by":"publisher"}],"name":"King Faisal Specialist Hospital & Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"Napoli F, Vella C, Ferri L, et al. 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