{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:25:26Z","timestamp":1748967926687,"version":"3.41.0"},"reference-count":0,"publisher":"Radcliffe Medical Media Ltd","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>The use of first-generation drug-eluting stents (DES) has been associated with safety concerns such as very late stent thrombosis. Today, with the release of newer DES, there is a need for comparative studies of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) to demonstrate their value in patients with high risk of restenosis such as diabetic patients. In a satellite symposium presented at EuroPCR 2014, the Cre8\u2122 DES was discussed. The Cre8 device has a number of unique clinical features, including polymer-free technology, abluminal reservoir technology and bio-inducer surface that ensure effective neointima suppression and rapid endothelialisation. The efficacy of the Cre8 DES has been demonstrated in the International randomised comparison between DES Limus Carbostent and Taxus drug-eluting stents in the treatment of de novo coronary lesions (NEXT) randomised clinical study, with equivalent efficacy in the diabetic and general populations, a unique finding. Ongoing clinical studies such as Investig8 and the Tel Aviv Medical Center (TLVMC) Cre8 study have confirmed the efficacy of the device in patient populations with a high proportion of diabetic patients. The Demonstr8 randomised trial has shown almost complete Cre8 strut coverage at three months with a numerical advantage versus bare metal stent (bare metal stents [BMS] \u2013 comparator device) at one month. In addition, use of the Cre8 DES may enable a shorter duration of dual antiplatelet therapy (DAPT) following PCI. The Cre8 DES therefore represents a significant advance in stent technology and may be particularly useful in challenging clinical settings<\/jats:p>","DOI":"10.15420\/icr.2014.9.3.184","type":"journal-article","created":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T11:41:31Z","timestamp":1410608491000},"page":"184","source":"Crossref","is-referenced-by-count":1,"title":["Meeting the Unmet \u2013 The Cre8 Polymer-free Drug-eluting Stents Technology"],"prefix":"10.15420","volume":"9","author":[{"given":"Katrina","family":"Mountfort","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Carri\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Valgimigli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Sardella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Banai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Romaguera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter","family":"Stella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Medical Writer, Radcliffe Cardiology, 7\/8 Woodlands Farm, Cookham Dean, Berks, SL6 9PN. E: katsmountfort@virginmedia.com","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Centre Hospitalier Universitaire Rangueil, Toulouse, France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The University Hospital of Ferrara, Ferrara, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Policlinico \u201cUmberto I,\u201d \u201cSapienza\u201d University, Rome, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Tel Aviv Medical Center, Tel Aviv, Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Hospital Universitari de Bellvitge-IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"University Medical Centre Utrecht, The Netherlands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6096","container-title":["Interventional Cardiology Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.icrjournal.com\/articleindex\/icr.2014.9.3.184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T13:56:49Z","timestamp":1623333409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.icrjournal.com\/articleindex\/icr.2014.9.3.184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"alternative-id":["articles\/meeting-unmet-cre8-polymer-free-drug-eluting-stents-technology"],"URL":"https:\/\/doi.org\/10.15420\/icr.2014.9.3.184","relation":{},"ISSN":["1756-1477"],"issn-type":[{"type":"print","value":"1756-1477"}],"subject":[],"published":{"date-parts":[[2014]]}}}