{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:12:25Z","timestamp":1774674745923,"version":"3.50.1"},"reference-count":0,"publisher":"Radcliffe Medical Media Ltd","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Despite improved clinical outcomes following the availability of second-generation drug eluting stents (DES), percutaneous coronary intervention (PCI) is associated with worse clinical and angiographic outcomes among patients with diabetes mellitus (DM) than among non-diabetics. The Cre8\u2122 Amphilimus-eluting DES is polymer-free, resulting in a reduced inflammatory response and lower risk of stent thrombosis. It showed equivalent efficacy and safety in diabetic and non-diabetic populations, a unique finding among DES studies. These findings were confirmed in a real-world study called INVESTIG8. Another real-world study, pARTicip8, is ongoing. The RESERVOIR clinical trial recruited patients with diabetes mellitus and showed noninferiority of the Cre8 DES compared to an everolimus-eluting DES but showed a statistical superiority of Cre8 in diabetic patients with higher metabolic dysfunctions. The Cre8 DES is therefore a valuable option for this important patient population.<\/jats:p>","DOI":"10.15420\/icr.2016.11.1.47","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T16:40:27Z","timestamp":1463848827000},"page":"47","source":"Crossref","is-referenced-by-count":4,"title":["The Use of the Cre8 Stent in Patients with Diabetes Mellitus"],"prefix":"10.15420","volume":"11","author":[{"given":"Didier","family":"Carri\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Cardiology, University Hospital Rangueil, Toulouse, France","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6096","container-title":["Interventional Cardiology Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.icrjournal.com\/articles\/use-cre8-stent-patients-diabetes-mellitus","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T13:30:15Z","timestamp":1564407015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.icrjournal.com\/articles\/use-cre8-stent-patients-diabetes-mellitus"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"aliases":["10.15420\/icr.2016.11.01.47"],"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"alternative-id":["icr.2016.11.1.47"],"URL":"https:\/\/doi.org\/10.15420\/icr.2016.11.1.47","relation":{},"ISSN":["1756-1477"],"issn-type":[{"value":"1756-1477","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}