{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:40:34Z","timestamp":1778938834254,"version":"3.51.4"},"reference-count":9,"publisher":"Radcliffe Medical Media Ltd","issue":"1","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interv Cardiol"],"published-print":{"date-parts":[[2019,2,25]]},"abstract":"<jats:p>In 2018, the world of functional mitral regurgitation changed with the presentation of two trials \u2013 Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR) and Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT). The trials, which seemed to point in two different directions, raised significant questions for the field. This article looks at the differences in effective regurgitant area, guideline-directed medical therapy, patient selection, technical clues and other reasons why the trials had similar aims but very different findings.<\/jats:p>","DOI":"10.15420\/icr.2018.40.1","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T14:15:48Z","timestamp":1551881748000},"page":"45-47","source":"Crossref","is-referenced-by-count":28,"title":["Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip"],"prefix":"10.15420","volume":"14","author":[{"given":"Kimberly","family":"Atianzar","sequence":"first","affiliation":[{"name":"Medical College of Georgia at Augusta University, Augusta, GA, US; Swedish Heart and Vascular Institute, Seattle, WA, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Swedish Heart and Vascular Institute, Seattle, WA, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Newhart","sequence":"additional","affiliation":[{"name":"Swedish Heart and Vascular Institute, Seattle, WA, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Gafoor","sequence":"additional","affiliation":[{"name":"Swedish Heart and Vascular Institute, Seattle, WA, US; CardioVascular Center Frankfurt, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6096","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Refining the prognostic impact of functional mitral regurgitation in chronic heart failure","DOI":"10.1093\/eurheartj\/ehx402"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment","DOI":"10.1161\/01.CIR.103.13.1759"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy","DOI":"10.1136\/hrt.2011.225789"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Survival and cardiovascular outcomes of patients with secondary mitral regurgitation: a systematic review and meta-analysis","DOI":"10.1001\/jamacardio.2017.2976"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 1: clinical trial design principles: a consensus document from the mitral valve academic research consortium","DOI":"10.1016\/j.jacc.2015.05.046"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Percutaneous repair or surgery for mitral regurgitation","DOI":"10.1056\/NEJMoa1009355"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Stone GW, Lindenfeld J, Abraham WT, et al. Transcatheter mitral-valve repair in patients with heart failure. N Engl J Med 2018;","DOI":"10.1056\/NEJMoa1806640"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Percutaneous repair or medical treatment for secondary mitral regurgitation","DOI":"10.1056\/NEJMoa1805374"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Proportionate and disproportionate functional mitral regurgitation: a new conceptual framework that reconciles the results of the MITRA-FR and COAPT trials","DOI":"10.1016\/j.jcmg.2018.11.006"}],"container-title":["Interventional Cardiology Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.icrjournal.com\/articleindex\/icr.2018.40.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T13:57:28Z","timestamp":1623333448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.icrjournal.com\/articleindex\/icr.2018.40.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.15420\/icr.2018.40.1","relation":{},"ISSN":["1756-1485","1756-1477"],"issn-type":[{"value":"1756-1485","type":"electronic"},{"value":"1756-1477","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2,5]]}}}