{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:42:21Z","timestamp":1791394941561,"version":"4.3.3"},"reference-count":58,"publisher":"Radcliffe Medical Media Ltd","issue":"2","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interv Cardiol"],"abstract":"<jats:p>Patients with symptoms and\/or signs of ischaemia but no obstructive coronary artery disease (INOCA) present a diagnostic and therapeutic challenge. Microvascular and\/or vasospastic angina are the two most common causes of INOCA; however, invasive coronary angiography lacks the sensitivity to diagnose these functional coronary disorders. In this article, the authors summarise the rationale for invasive testing in the absence of obstructive coronary disease, namely that correct treatment for angina patients starts with the correct diagnosis. They provide insights from the CORonary MICrovascular Angina (CorMicA) study, where an interventional diagnostic procedure was performed with linked medical therapy to improve patient health. Identification of these distinct disorders (microvascular angina, vasospastic angina or non-cardiac chest pain) is key for stratifying INOCA patients, allowing prognostic insights and better patient care with linked therapy based on contemporary guidelines. Finally, they propose a framework to diagnose and manage patients in this common clinical scenario.<\/jats:p>","DOI":"10.15420\/icr.2019.04.r1","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T05:41:47Z","timestamp":1558676507000},"page":"76-82","source":"Crossref","is-referenced-by-count":74,"title":["How to Diagnose and Manage Angina Without Obstructive Coronary Artery Disease: Lessons from the British Heart Foundation CorMicA Trial"],"prefix":"10.15420","volume":"14","author":[{"given":"Thomas J","family":"Ford","sequence":"first","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, UK; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Berry","sequence":"additional","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, UK; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015","DOI":"10.1016\/S0140-6736(16)31012-1"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Percutaneous coronary interventions in Europe: prevalence, numerical estimates, and projections based on data up to 2004","DOI":"10.1007\/s00392-007-0513-0"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Low diagnostic yield of elective coronary angiography","DOI":"10.1056\/NEJMoa0907272"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events","DOI":"10.1093\/eurheartj\/ehr331"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Nonobstructive coronary artery disease and risk of myocardial infarction","DOI":"10.1001\/jama.2014.14681"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Natural history of patients with insignificant coronary artery disease","DOI":"10.1093\/ehjqcco\/qcv034"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. 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