{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:00:58Z","timestamp":1753887658694,"version":"3.41.2"},"reference-count":12,"publisher":"Radcliffe Medical Media Ltd","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interv Cardiol"],"abstract":"<jats:p>Erdheim\u2013Chester disease (ECD) is a rare non-Langerhans cell histiocytosis characterised by multiorgan pathological histiocytic infiltration. Cardiac involvement occurs in 40\u201375% of patients and increases mortality. A 55-year-old woman with chest pain and dyspnoea was found to have an interatrial septal mass and aortitis suspicious for ECD without other organ involvement. After two inadequate transcatheter interatrial biopsies were obtained using ultrasound guidance alone, diagnostic samples were successfully obtained using intraprocedural frozen section examination. The patient started genotype-targeted treatment with good response. Biopsy confirmation of ECD is required to guide treatment; however, cardiac biopsies are uncommonly performed when other organs are affected. Our unique case of isolated cardiovascular involvement highlights how frozen sectioning with multimodal intraprocedural imaging guidance can improve diagnostic yield of endomyocardial biopsies. It also highlights how diagnosis of rare conditions requires careful multidisciplinary evaluation of affected organs, procedural risk and diagnostic yield. The use of frozen sectioning can improve diagnostic yield of endomyocardial biopsies.<\/jats:p>","DOI":"10.15420\/icr.2024.32","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T12:29:04Z","timestamp":1742214544000},"source":"Crossref","is-referenced-by-count":0,"title":["Novel Diagnosis of Isolated Cardiac Erdheim\u2013Chester Disease by Interatrial Biopsy Using Frozen Section Examination"],"prefix":"10.15420","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9776-7034","authenticated-orcid":false,"given":"Jasraj","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic, Rochester, MN, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-3535","authenticated-orcid":false,"given":"Newton B","family":"Neidert","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Vascular and Interventional Radiology, Mayo Clinic, Rochester, MN, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-0707","authenticated-orcid":false,"given":"Jason H","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Mayo Clinic, Rochester, MN, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3295-4427","authenticated-orcid":false,"given":"Andrew J","family":"Layman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6770-2339","authenticated-orcid":false,"given":"Karen L","family":"Rech","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Rochester, MN, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-3495","authenticated-orcid":false,"given":"Ronald S","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-2398","authenticated-orcid":false,"given":"William G","family":"Breen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Rochester, MN, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-8810","authenticated-orcid":false,"given":"Phillip M","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-8266","authenticated-orcid":false,"given":"Jason R","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Jacksonville, FL, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-6755","authenticated-orcid":false,"given":"Matthew J","family":"Koster","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN, US"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6096","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Ozkaya N, Rosenblum MK, Durham BH, et al. The histopathology of Erdheim\u2013Chester disease: a comprehensive review of a molecularly characterized cohort. Mod Pathol 2018;31:581\u201397. https:\/\/doi.org\/10.1038\/modpathol.2017.160; PMID:\u00a029192649.","DOI":"10.1038\/modpathol.2017.160"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Estrada-Veras JI, O\u2019Brien KJ, Boyd LC, et al. The clinical spectrum of Erdheim\u2013Chester disease: an observational cohort study. Blood Adv 2017;1:357\u201366. https:\/\/doi.org\/10.1182\/bloodadvances.2016001784; PMID:\u00a028553668.","DOI":"10.1182\/bloodadvances.2016001784"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Goyal G, Heaney ML, Collin M, et al. Erdheim\u2013Chester disease: consensus recommendations for evaluation, diagnosis, and treatment in the molecular era. 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