{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:03:00Z","timestamp":1778637780065,"version":"3.51.4"},"reference-count":28,"publisher":"Radcliffe Medical Media Ltd","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interv Cardiol"],"abstract":"<jats:p>Aortic regurgitation (AR) is the third most common valvular heart disease, with its prevalence and severity increasing with age. AR can arise from degenerative, congenital, inflammatory and infectious aetiologies, manifesting as primary AR with intrinsic leaflet disease, secondary AR due to aortopathy or annular dilatation, or a combination. Furthermore, AR can be acute, as observed in endocarditis and aortic dissection, or chronic, as seen in calcific aortic valve disease, connective tissue disorders, or bicuspid valve phenotypes. This review discusses the aetiopathology of these various AR manifestations (primary, secondary, acute and chronic AR), highlighting diagnostic challenges and implications for aortic valve replacement and transcatheter aortic valve implantation.<\/jats:p>","DOI":"10.15420\/icr.2024.37","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T14:47:40Z","timestamp":1740926860000},"source":"Crossref","is-referenced-by-count":3,"title":["Incidence and Pathology of Aortic Regurgitation"],"prefix":"10.15420","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1273-3612","authenticated-orcid":false,"given":"Lucas","family":"Uchoa de Assis","sequence":"first","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-4678","authenticated-orcid":false,"given":"Giulio M","family":"Mondellini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2124-109X","authenticated-orcid":false,"given":"Mark MP","family":"van den Dorpel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8662-9201","authenticated-orcid":false,"given":"Jenna","family":"van Niekerk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-1205","authenticated-orcid":false,"given":"Nicolas M","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6096","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Andell P, Li X, Martinsson A, et al. 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