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Methods: A comprehensive search of PubMed, EMBASE and Cochrane identified studies comparing PCI timing strategies in TAVI patients. Results: Thirteen studies with 15,412 participants were included. Mortality at 30\u00a0days (OR 5.70; 95% CI [1.34\u201324.36]) and 2\u00a0years (OR 4.40; 95% CI [2.60\u20137.44]) were significantly higher in the combined pre-TAVI and concomitant PCI group than in the post-TAVI cohort. Rates of other periprocedural complications, such as stroke and bleeding, varied across studies. Conclusion: There is no clear consensus on PCI timing in TAVI due to a lack of high-quality randomised data. An individualised, algorithmic approach is proposed for managing CAD in patients undergoing TAVI.<\/jats:p>","DOI":"10.15420\/icr.2024.51","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T15:43:18Z","timestamp":1750520598000},"source":"Crossref","is-referenced-by-count":2,"title":["Management of Coronary Artery Disease in the Context of Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-analysis of Percutaneous Coronary Intervention Timing and an Algorithmic Approach to Management"],"prefix":"10.15420","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-4379","authenticated-orcid":false,"given":"Cian","family":"Murray","sequence":"first","affiliation":[{"name":"Cardiology Department, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9458-1305","authenticated-orcid":false,"given":"Caoimhe","family":"Ryan","sequence":"additional","affiliation":[{"name":"Cardiology Department, Mater Misericordiae University Hospital, Dublin,\u00a0Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-1668","authenticated-orcid":false,"given":"Michael","family":"Cronin","sequence":"additional","affiliation":[{"name":"Cardiology Department, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-3431","authenticated-orcid":false,"given":"Hugo","family":"Temperley","sequence":"additional","affiliation":[{"name":"Radiology Department, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-7819","authenticated-orcid":false,"given":"Niall","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"Radiology Department, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6539-0375","authenticated-orcid":false,"given":"Stephen","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Cardiology Department, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-5828","authenticated-orcid":false,"given":"Andrew","family":"Maree","sequence":"additional","affiliation":[{"name":"Cardiology Department, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-6446","authenticated-orcid":false,"given":"Mark","family":"Hensey","sequence":"additional","affiliation":[{"name":"Cardiology Department, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"ref0","unstructured":"Vahanian A, Beyersdorf F, Praz F, et al. 2021 ESC\/EACTS Guidelines for the management of valvular heart disease. 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