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Methods: This was a prospective, single-arm, multicentre registry (August 2020\u2013November 2022) of patients with complex lesions \u2013 left main, bifurcations, small vessels and long lesions \u2013 treated with Ultimaster TANSEI DES and followed for 1 year. The primary endpoint was the device-oriented composite endpoint (DoCE), including cardiac death, target-vessel MI, target-vessel revascularisation (TVR) and stent thrombosis. The secondary endpoint was the patient-oriented composite endpoint (PoCE), including all-cause death, any MI and any revascularisation. Results: In total, 501 patients with 591 complex lesions (mean age 66.7 years; 79.6% male; 33.4% with diabetes) were treated. Lesion types: left main 11%, bifurcations 43.9%, small vessels 40.7%, long lesions 34.3%. At 1 year, incidence rates were: DoCE 3.23 per 100 person-years (95% CI [1.84\u20135.24]) and PoCE 5.04 per 100 person-years (95% CI [3.26\u20137.44]). In subgroup analyses, long lesions (&gt;35 mm) showed consistently higher risk: DoCE RR 4.22 (95% CI [1.49\u201311.95]; p=0.006), PoCE RR 4.93 ([2.10\u201311.57]; p&lt;0.001), overall mortality RR 4.79 [1.53\u201315.06]; p=0.007) and TVR RR 17.60 [2.22\u2013139.51]; p&lt;0.001).<\/jats:p>","DOI":"10.15420\/icr.2025.33","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:57:43Z","timestamp":1774871863000},"source":"Crossref","is-referenced-by-count":0,"title":["Ultimaster TANSEI Stent in Complex Coronary Lesions: The EPIC08 TANSEI COMPLEX Study"],"prefix":"10.15420","author":[{"given":"Ricardo","family":"Palma-Carbajal","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ba28x55","id-type":"ROR","asserted-by":"publisher"}],"name":"Vall d'Hebron Hospital 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