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Early diagnosis, identification of the underlying cause, and targeted treatments aimed at mitigating right heart failure are crucial in management. Although new therapies have emerged recently, it is still a condition with high morbidity and mortality that requires specialized multidisciplinary care. The aim of this study is to review the current literature on key aspects of pulmonary arterial hypertension.<\/jats:p>","DOI":"10.15420\/usc.2025.05","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:45:58Z","timestamp":1769510758000},"source":"Crossref","is-referenced-by-count":0,"title":["The Pathophysiology, Mechanism, Diagnosis, and Management of Pulmonary Arterial Hypertension: A Comprehensive Literature Review"],"prefix":"10.15420","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-0866","authenticated-orcid":false,"given":"Apoorva","family":"Gangavelli","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8559-3073","authenticated-orcid":false,"given":"Ronaldo C","family":"Fabiano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04ehecz88","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5245-8724","authenticated-orcid":false,"given":"Mariam","family":"Riad","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01s7b5y08","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-7722","authenticated-orcid":false,"given":"Gurleen","family":"Kaur","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04b6nzv94","id-type":"ROR","asserted-by":"publisher"}],"name":"Brigham and Women's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1287-6440","authenticated-orcid":false,"given":"Devesh","family":"Rai","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05yjze111","id-type":"ROR","asserted-by":"publisher"}],"name":"Unity Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0482-4560","authenticated-orcid":false,"given":"Mardi","family":"Gomberg-Maitland","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00y4zzh67","id-type":"ROR","asserted-by":"publisher"}],"name":"George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6096","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref0","unstructured":"Humbert M, Kovacs G, Hoeper MM, et al. 2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. 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