{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:45:11Z","timestamp":1740174311997,"version":"3.37.3"},"reference-count":44,"publisher":"The Korean Society of Emergency Medicine","issue":"1","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and ICT of Korea","doi-asserted-by":"publisher","award":["2021R1A2C2004922"],"award-info":[{"award-number":["2021R1A2C2004922"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ceemjournal.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Emerg Med"],"abstract":"<jats:p>Objective Carbon monoxide (CO) poisoning causes brain injury by hypoxia and inflammatory mechanisms. Hypoxic conditions result in increased serum phosphate concentration due to loss of polarity of the cell membrane, changes in membrane fluidity, and consequent destruction of phospholipids in the cell membrane. This study aimed to evaluate whether serum phosphate measured in the emergency department (ED) can serve as an early predictor of neurocognitive sequelae 1 month after acute CO poisoning.Methods We included patients \u226516 years with acute CO poisoning from a cohort who were treated at a single tertiary academic hospital in Wonju, Korea, between January 2006 and May 2021. Neurocognitive outcome was assessed using the Global Deterioration Scale score; patients were classified into favorable (1\u20133 points) or poor (4\u20137 points) neurocognitive outcome groups based on this score. These two groups were compared before and after propensity score matching.Results Data from 888 patients were analyzed. Seven hundred seventy-one patients (86.8%) were assigned to the favorable outcome group and 117 patients (13.2%) to the poor outcome group. Patients with a poor outcome had a higher mean serum phosphate level than those with a favorable outcome (3.9 mg\/dL vs. 3.5 mg\/dL, P=0.001). Propensity score matching yielded 85 matched patient pairs. After matching, serum phosphate level in the ED was not significantly different between the favorable and poor outcome groups (3.9 vs. 3.7 mg\/dL, P=0.349).Conclusion Serum phosphate level measured in the ED did not predict poor neurocognitive outcomes 1 month after CO poisoning.<\/jats:p>","DOI":"10.15441\/ceem.22.299","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:46:31Z","timestamp":1664495191000},"page":"74-83","update-policy":"https:\/\/doi.org\/10.15441\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum phosphate is not an early predictor of neurocognitive outcomes in acute carbon monoxide poisoning patients"],"prefix":"10.15441","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4628-0653","authenticated-orcid":true,"given":"Yuseon","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-1758","authenticated-orcid":true,"given":"Sung Hwa","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9897-4273","authenticated-orcid":true,"given":"Yong Sung","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6106","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201606-1275ci"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp0808891"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199811263392206"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050070063016"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2009.09.030"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.15441\/ceem.20.099"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-0644(95)70261-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa013121"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0b013e3181a0064f"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.04.026"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.658918"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.15441\/ceem.17.217"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0960327117698544"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2007.11.021"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2005.08.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1991.260.6.f769"},{"key":"ref17","first-page":"121","volume-title":"Developmental differences in myocardial ATP metabolism","author":"de Jong","year":"1987"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90044-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2011.05.051"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(90)90217-g"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2011.10.009"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2008.03.001"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/cc3714"},{"key":"ref24","first-page":"593","volume-title":"The significance of elevation of serum phosphate levels in experimental intestinal ischemia","author":"Lores","year":"1981"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058348"},{"volume-title":"Carbon monoxide poisoning","year":"2019","author":"Weaver","key":"ref26"},{"key":"ref27","first-page":"801","volume-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","author":"Singer","year":"2016"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.553198"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.139.9.1136"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000004419"},{"key":"ref31","first-page":"1758","volume-title":"Myocardial injury and fibrosis from acute carbon monoxide poisoning: a prospective observational study","author":"Cho","year":"2021"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000005112"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0258(19981015)17:19<2265::aid-sim918>3.0.co;2-b"},{"volume-title":"Matching seems easy, but not that easy","year":"2007","author":"Kleinbaum","key":"ref34"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002\/pst.433"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq224"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800691317"},{"key":"ref38","first-page":"19","volume-title":"Changes in serum phosphate levels associated with intestinal infarction and necrosis","author":"Jamieson","year":"1975"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.851873"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0074-7"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1208943"},{"key":"ref42","first-page":"259","volume-title":"Serum inorganic phosphate levels in experimental intestinal ischaemia","author":"Sodhi","year":"1993"},{"key":"ref43","first-page":"272","volume-title":"Diagnosis of intestinal ischemia by measurement of serum phosphate and enzyme changes and the effectiveness of vitamin E treatment","author":"Uncu","year":"1999"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.113752"}],"container-title":["Clinical and Experimental Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ceemjournal.org\/upload\/pdf\/ceem-22-299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ceemjournal.org\/journal\/view.php?doi=10.15441\/ceem.22.299","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ceemjournal.org\/upload\/pdf\/ceem-22-299.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:51:20Z","timestamp":1680673880000},"score":1,"resource":{"primary":{"URL":"http:\/\/ceemjournal.org\/journal\/view.php?doi=10.15441\/ceem.22.299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,3,5]]}},"URL":"https:\/\/doi.org\/10.15441\/ceem.22.299","relation":{},"ISSN":["2383-4625"],"issn-type":[{"type":"electronic","value":"2383-4625"}],"subject":[],"published":{"date-parts":[[2022,9,30]]},"assertion":[{"value":"2022-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}