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Such events include EoT, characterized by endothelial glycocalyx damage, and ATC, involving platelet dysfunction, fibrinogen depletion, and dysregulated fibrinolysis. To manage blood failure effectively, a multifaceted approach is crucial. Damage control resuscitation strategies such as use of permissive hypotension, early hemorrhage control, and aggressive transfusion of blood products including whole blood aim to minimize oxygen debt and promote its repayment while addressing endothelial damage and coagulation. Transfusions of red blood cells, plasma, and platelets, as well as the use of tranexamic acid, play key roles in hemostasis and countering ATC. Whole blood, whether fresh or cold-stored, is emerging as a promising option to address multiple needs in traumatic hemorrhage. This review underscores the intricate relationships between oxygen debt, EoT, and ATC and highlights the importance of comprehensive, integrated strategies in the management of traumatic hemorrhage to prevent blood failure. A multidisciplinary approach is essential to address these interconnected factors effectively and to improve patient outcomes.<\/jats:p>","DOI":"10.15441\/ceem.23.127","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T07:38:55Z","timestamp":1701243535000},"page":"9-21","update-policy":"https:\/\/doi.org\/10.15441\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Blood failure: traumatic hemorrhage and the interconnections between oxygen debt, endotheliopathy, and coagulopathy"],"prefix":"10.15441","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2429-4085","authenticated-orcid":true,"given":"Jae Hyuk","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-409X","authenticated-orcid":true,"given":"Kevin 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