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A comprehensive search was conducted across three prominent databases (Google Scholar, PubMed, and Science Direct) to identify relevant articles. The search focused on the keywords \u201cMgSO4\u201d or \u201cmagnesium sulfate\u201d in conjunction with \u201corganophosphate\u201d or \u201corganophosphate poisoning.\u201d Inhibition of acetylcholine transferase enzyme results in the accumulation of acetylcholine in synapses and the stimulation of cholinergic receptors. As several studies have shown that magnesium sulfate (MgSO4) can inhibit the release of acetylcholine in the central and peripheral sympathetic and parasympathetic synapses, this study reviews the role of MgSO4 in the treatment of organophosphorus poisoning. 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