{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:05:46Z","timestamp":1780603546901,"version":"3.54.1"},"reference-count":27,"publisher":"The Korean Society of Emergency Medicine","issue":"3","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["ceemjournal.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Emerg Med"],"abstract":"<jats:p>Objective: Ketamine is a promising drug for analgesia in emergency medicine, but the high rate of side effects is a barrier to widespread usage. We hypothesized that ketamine bolus followed by ketamine infusion would provide a more even and longer duration of analgesia and lower rates of side effects in comparison to bolus-only administration.Methods: This was a double-blinded clinical trial. Eligible trauma patients were randomly allocated with the numeric rating scale \u22656 in two study groups. The first group received a dose of 0.3 mg\/kg of ketamine over 1 minute, followed by an infusion of saline 0.9% over the next 30 minutes (bolus-only group). The second group was given 0.15 mg\/kg of ketamine over 1 minute, followed by an infusion of 0.15 mg\/kg over the next 30 minutes (bolus-and-infusion group). The primary outcome was to measure the average reduction in pain scores.Results: In total, 80 patients were recruited. Of these, 77 patients were analyzed. Both groups achieved a statistically significant decrease in pain scores (all P&lt;0.001). After 30 minutes, patients in the bolus-and-infusion group reported lower pain scores in all intervals with lower rates of need for rescue analgesia, but this difference was not statistically significant. Vital signs remained stable during the study in both groups. No statistically significant difference was observed between study groups for any side effect (P&lt;0.05).Conclusion: Both administration protocols resulted in significant pain control. No statistically significant difference was observed between study groups in terms of analgesic efficacy and side effects.<\/jats:p>","DOI":"10.15441\/ceem.24.244","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T02:51:51Z","timestamp":1736823111000},"page":"259-266","update-policy":"https:\/\/doi.org\/10.15441\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the efficacy of bolus low-dose ketamine versus bolus plus infusion low-dose ketamine on pain management in emergency departments: a randomized clinical trial"],"prefix":"10.15441","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5823-4374","authenticated-orcid":true,"given":"Reza","family":"Azizikhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5995-809X","authenticated-orcid":true,"given":"Ali","family":"Sanaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-0045","authenticated-orcid":true,"given":"Farhad","family":"Heydari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2985-5104","authenticated-orcid":true,"given":"Saeed","family":"Majidinejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-5119","authenticated-orcid":true,"given":"Keihan","family":"Golshani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4989-7899","authenticated-orcid":true,"given":"Fateme","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9747-2564","authenticated-orcid":true,"given":"Pardis","family":"Rafiei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6106","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1051\/sicotj\/2019028"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2021.03.025"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12093289"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071353"},{"key":"ref5","first-page":"5","volume-title":"Problems and barriers of pain management in the emergency department: are we ever going to get better?","author":"Motov","year":"2008"},{"key":"ref6","first-page":"22","volume-title":"Acute pain management and perceptions among emergency healthcare workers: feedback from Greece","author":"Theodosopoulou","year":"2023"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.05.022"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4274\/eajem.galenos.2020.67689"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0383-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.07.059"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/aap.0000000000000806"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-017-1299-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei316"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.58368"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.36250"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/acem.14159"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13428"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2017.03.004"},{"key":"ref19","first-page":"647","volume-title":"A randomized, noninferiority, controlled trial of two doses of intravenous subdissociative ketamine for analgesia in the emergency department","author":"Lovett","year":"2021"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12705"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmilitary-2020-001443"},{"key":"ref23","volume-title":"Create a blocked randomisation list [Internet]"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12706"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2023.08.025"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3109\/10903127.2014.923076"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2023.05.026"}],"container-title":["Clinical and Experimental Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ceemjournal.org\/upload\/pdf\/ceem-24-244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ceemjournal.org\/journal\/view.php?doi=10.15441\/ceem.24.244","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ceemjournal.org\/upload\/pdf\/ceem-24-244.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T06:09:00Z","timestamp":1759212540000},"score":1,"resource":{"primary":{"URL":"http:\/\/ceemjournal.org\/journal\/view.php?doi=10.15441\/ceem.24.244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.15441\/ceem.24.244","relation":{},"ISSN":["2383-4625"],"issn-type":[{"value":"2383-4625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]},"assertion":[{"value":"2024-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}