{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:43:46Z","timestamp":1782809026209,"version":"3.54.5"},"reference-count":28,"publisher":"The Korean Society of Emergency Medicine","issue":"2","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UM1TR004400"],"award-info":[{"award-number":["UM1TR004400"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ceemjournal.org"],"crossmark-restriction":true},"short-container-title":["CEEM"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>Objective: Emergency physicians have become hesitant to treat patients with opioids because of downstream sequelae related to opioid use disorder. We enrolled a prospective cohort to determine whether the experience of a patient receiving an intravenous (IV) opioid was associated with multiple opioid prescriptions. Specifically, we tested whether greater improvements in pain and a larger euphoric response could predict which previously opioid-naive patients exposed to IV opioids would fill at least two opioid prescriptions in the subsequent 6 months.Methods: We recorded pain scores (range, 0\u201310) before and 15 minutes after opioid-naive emergency department patients were given IV opioids to manage severe pain. We also determined opioid-induced euphoria (range, 0\u201310 points) by querying the good feelings, experience of being high, and level of euphoria caused by the opioid and the likelihood of participant reuse of the opioid. Six-month outcomes were ascertained using the state prescription monitoring database.Results: Among 506 patients, 32 (6.3%) filled at least two prescriptions during the 6 months following the emergency department visit. There were no differences in pain relief between those who filled at least two prescriptions and those who did not (P=0.54), the good feelings imparted by the medication (P=0.91), the drug high caused by the medication (P=0.97), level of euphoria (P=0.23), or likelihood of participant reuse of the opioid (P=0.37).Conclusion: Filling at least two opioid prescriptions was uncommon after initial exposure to therapeutic IV opioids and was unrelated to either analgesic efficacy or opioid-induced euphoria.<\/jats:p>","DOI":"10.15441\/ceem.25.056","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T08:22:51Z","timestamp":1764663771000},"page":"207-212","update-policy":"https:\/\/doi.org\/10.15441\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of acute opioid-induced euphoria and analgesia with subsequent opioid prescriptions in an emergency department\u2013based prospective cohort 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