{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:00:50Z","timestamp":1777460450660,"version":"3.51.4"},"reference-count":8,"publisher":"Universidad Nacional de Colombia","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. salud p\u00fablica"],"abstract":"<p><strong>Objetivo<\/strong> Estudiar cl\u00ednica y epidemiol\u00f3gicamente focos de LV urbana en Neiva (Huila).<\/p><p><strong>Materiales y M\u00e9todos<\/strong> Seis ni\u00f1os consultaron por hepato-esplenomegalia. Presentaban anemia y leucopenia. Se realiz\u00f3 biopsia por aspiraci\u00f3n de medula \u00f3sea (5 pacientes) y de bazo (1 paciente). Se hizo b\u00fasqueda activa de casos en la comunidad y de anticuerpos anti-<em>Leishmania infantum<\/em> por inmunofluorescencia indirecta (IFI) en los sintom\u00e1ticos y en reservorios caninos (IFI, rK39). Se hicieron visitas domiciliarias para educaci\u00f3n comunitaria y b\u00fasqueda de vectores. Los pacientes recibieron Miltefosina, Anfotericina B o Glucantime<sup>\u00ae<\/sup>.<\/p><p><strong>Resultados <\/strong>Se confirm\u00f3 LV en siete ni\u00f1os. En seis, el aspirado de medula \u00f3sea o bazo demostr\u00f3 amastigotes. La IFI fue positiva en 4 pacientes y negativa en 3. Un ni\u00f1o se detect\u00f3 por b\u00fasqueda activa comunitaria, con cl\u00ednica de LV, confirmada por IFI (1:32). La miltefosina no fue \u00fatil en 6 de los 7 casos. La Anfotericina B liposomal o deoxicolato, cur\u00f3 6 pacientes y el Glucantime\u00ae uno. La seroprevalencia en 1182 caninos (IFI y rK39) fue de 6.1 %; los animales positivos fueron sacrificados. Se demostr\u00f3 <em>Lu. longipalpis, <\/em>vector de LV, en el peridomicilio.<\/p><p><strong>Conclusiones<\/strong> Demostramos LV urbana en dos comunas de Neiva. La confirmaci\u00f3n diagn\u00f3stica incluy\u00f3 aspiraci\u00f3n de medula \u00f3sea e IFI. La Miltefosina no fue \u00fatil. La Anfotericina B liposomal fue la terapia ideal. Para controlar la LV es necesario hacer BAC, educaci\u00f3n comunitaria, control de vectores y reservorios.<\/p><\/jats:p>","DOI":"10.15446\/rsap.v17n4.44663","type":"journal-article","created":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T18:56:08Z","timestamp":1449514568000},"page":"514-527","source":"Crossref","is-referenced-by-count":10,"title":["Brote urbano de leishmaniasis visceral en Neiva (Huila), 2012"],"prefix":"10.15446","volume":"17","author":[{"given":"Clara del Pilar","family":"Zambrano Hernandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha Stella","family":"Ayala Sotelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Patricia","family":"Fuya Oviedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Andres","family":"Montenegro Puentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy Milena","family":"Aya Vanegas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Gerzain","family":"Rodriguez Toro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Lorena","family":"Becerra Osorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Aguilera Jaramillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto","family":"Lozano Polanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Clemencia","family":"Rojas Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavio","family":"Bl\u00e1squez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6146","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762001000200004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1590\/S0124-00642009000400015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.04.023"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2010.07.012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v26i1.1514"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(99)90037-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903627"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v34i1.2153"}],"container-title":["Revista de Salud P\u00fablica"],"original-title":[],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T18:29:31Z","timestamp":1710268171000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/view\/44663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,7]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,12,7]]}},"URL":"https:\/\/doi.org\/10.15446\/rsap.v17n4.44663","relation":{},"ISSN":["0124-0064"],"issn-type":[{"value":"0124-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,7]]}}}