{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:53:38Z","timestamp":1764842018673,"version":"3.41.0"},"reference-count":104,"publisher":"Universidad Nacional de Colombia","issue":"3","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. salud p\u00fablica"],"abstract":"<jats:p>Objetivo Identificar los factores de riesgo maternos, fetales y neonatales asociados a la hipoxia perinatal en los reci\u00e9n nacidos del Hospital Universitario Mayor Mederi (HUM Mederi), per\u00edodo 2007 a 2011.Metodolog\u00eda Del total de reci\u00e9n nacidos (8 837) en los a\u00f1os 2007 a 2011, en el HUMMederi, se tomaron los casos que presentaron asfixia perinatal (AP) seg\u00fan la ACOG u otro diagn\u00f3stico de Dificultad Respiratoria (DR). Fuente: Registros del sistema inform\u00e1ticode Servicio de Neonatolog\u00eda del Hospital Universitario Mayor Mederi. Se analizaron los factores de riesgo materno, fetal y neonatal. Los datos se mostraron de acuerdo al n\u00famero de reci\u00e9n nacidos en cada grupo y en forma porcentual.Resultados La tasa de mortalidad global fue de 10,7. Los valores m\u00e1s bajos fueron enlos a\u00f1os 2010 y 2011: 3.3 y 1.8 espectivamente. Diabetes gestacional, hipertensi\u00f3n, corioamnionitis y placenta previa fueron m\u00e1s frecuentes en el grupo con DR, mientras que hipoglicemia y sepsis lo fueron en el grupo con AP as\u00ed como hipoton\u00eda e hipoactividad entre las alteraciones neurol\u00f3gicas. Fue baja la correspondencia entre las alteraciones neurol\u00f3gicas y el Test de Apgar en los casos diagnosticados con AP.Conclusiones La tasa de mortalidad fue muy baja comparada a nivel regional y local. Hubo mayor n\u00famero de reci\u00e9n nacidos con asfixia perinatal moderada. Los resultados del estudio coinciden con lo reportado. El mayor n\u00famero de pre-t\u00e9rmino en los reci\u00e9nnacidos con DR enfatiza la importancia de controlar el implemento de acciones para disminuir los factores de riesgo asociados a esta condici\u00f3n.<\/jats:p>","DOI":"10.15446\/rsap.v19n3.65204","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T17:26:09Z","timestamp":1516209969000},"page":"332-339","source":"Crossref","is-referenced-by-count":3,"title":["Hipoxia perinatal en el Hospital Mederi de Bogot\u00e1: comportamiento en los a\u00f1os 2007 a 2011"],"prefix":"10.15446","volume":"19","author":[{"given":"Lilia","family":"Del Riesgo Prendes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba Luc\u00eda","family":"Salamanca Matta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Agust\u00edn","family":"Monterrey Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Andr\u00e9s","family":"Berm\u00fadez Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Luis","family":"V\u00e9lez Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Su\u00e1rez Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6146","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"ref1","unstructured":"Neonatal and perinatal Mortality: Country, regional and global estimates 2006. Organizaci\u00f3n Mundial de la Salud. Ginebra."},{"key":"ref2","unstructured":"OMS. Estad\u00edsticas Sanitarias Mundiales OMS 2012. Estad\u00edsticas Sanitarias Mundiales ISBN 978 924356 444 9."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Berger R, Garnier Y and Jensen A. Perinatal Brain Damage: Underlying Mechanisms and Neuroprotective Strategies. Journal of the Society for Gynecologic Investigation. 2002;9: 319-328.","DOI":"10.1177\/107155760200900601"},{"key":"ref4","unstructured":"Bass JL, Corwin M, Gozal D, Moore C, Nishida H, Parker S,"},{"key":"ref5","unstructured":"Schonwald A, Wilker RE, Stehle S and Kinane TB. The Effect"},{"key":"ref6","unstructured":"of Chronic or Intermittent Hypoxia on Cognition in Childhood:"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"A Review of the Evidence. Pediatrics. 2004; 114: 805-816.","DOI":"10.1542\/peds.2004-0227"},{"key":"ref8","unstructured":"Dirnagl U, Ladecola C and Moskowitz M.A. Pathobiology of"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"ischaemic stroke: an integrated view. Trends Neuroscience. 1999; 22: 391-397.","DOI":"10.1016\/S0166-2236(99)01401-0"},{"key":"ref10","unstructured":"Ucr\u00f3s S y Mej\u00eda N. Asfixia Perinatal. Gu\u00edas de Pediatr\u00eda pr\u00e1ctica basadas en la evidencia. 2\u00aa Edici\u00f3n. Editorial Panamericana. P\u00e1ginas: 116-137; 2009."},{"key":"ref11","unstructured":"The American College of Obstetricians and Gynecologistis."},{"key":"ref12","unstructured":"Fetal and neonatalneurologic injury. American Academy of"},{"key":"ref13","unstructured":"Pediatrics. Neonatal encephalopathy and cerebral palsy:"},{"key":"ref14","unstructured":"defining the pathogenesis and pathophysicology. Washinton,"},{"key":"ref15","unstructured":"DC:American College of Obstetricians and Gynecologistis,"},{"key":"ref16","unstructured":""},{"key":"ref17","unstructured":"Cullen P y Salgado E. Conceptos b\u00e1sicos para el manejo de"},{"key":"ref18","unstructured":"la asfixia perinatal y la encefalopat\u00eda hip\u00f3xico-isqu\u00e9mica en"},{"key":"ref19","unstructured":"el neonato. Trabajo de Revisi\u00f3n. Revista Mexicana de Pediatr\u00eda."},{"key":"ref20","unstructured":"; 76 (4): 174-180."},{"key":"ref21","unstructured":"Jeffrey M. Perlman. Intrapartum Hypoxic-Ischemic Cerebral"},{"key":"ref22","unstructured":"Injury and Subsequent Cerebral Palsy: Medicolegal Issues."},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Pediatrics. 1997; 99:851-859.","DOI":"10.1542\/peds.99.6.851"},{"key":"ref24","unstructured":"Ortiz EI. Estrategias para la prevenci\u00f3n del bajo peso al nacer en una poblaci\u00f3n de alto riesgo, seg\u00fan la medicina basada"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"en la evidencia. Colombia M\u00e9dica; 2001; 32: 159-162.","DOI":"10.25100\/cm.v32i.4.203"},{"key":"ref26","unstructured":"del Riesgo L, G\u00f3mez A, Berm\u00fadez S, y G\u00f3mez J. Efectos de"},{"key":"ref27","unstructured":"la furosemida en ratas sometidas a hipoxia cr\u00f3nica severa."},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Revista Cient\u00edfica. 2001 (1): 155-164.","DOI":"10.1023\/A:1004175605236"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Ferrer-Abizanda. Mecanismos de muerte neuronal en la isquemia cerebral. Rev. Neurol.1999; 27 (6):515-521.","DOI":"10.33588\/rn.2906.99173"},{"key":"ref30","unstructured":"Yuko Tanaka F, Hayashi T, Kitajima H, Sumi K and Fujimura"},{"key":"ref31","unstructured":"M. Infants With Persistent Pulmonary Hypertension of the"},{"key":"ref32","unstructured":"Newborn Inhaled Nitric Oxide Therapy Decreases the Risk of"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Cerebral Palsy in Preterm. Pediatrics 2007; 119: 1159-1164","DOI":"10.1542\/peds.2006-2269"},{"key":"ref34","unstructured":"Sun X, Shih AY, Johannssen HC, Erb H, Li P, and Murphy"},{"key":"ref35","unstructured":"TH. Two-photon Imaging of Glutathione Levels in Intact Brain"},{"key":"ref36","unstructured":"Indicates Enhanced Redox Buffering in Developing Neurons"},{"key":"ref37","unstructured":"and Cells at the Cerebrospinal Fluid and Blood-Brain"},{"key":"ref38","unstructured":"Interface. The Journal of Biological Chemistry. 2006; 281 (5):"},{"key":"ref39","unstructured":"\u201317431."},{"key":"ref40","unstructured":"Grad E, Golomb M, Mor-Yosef I, Koroukhov N, Lotan Ch,."},{"key":"ref41","unstructured":"Edelman E and Danenberg HD. Transgenic expression of"},{"key":"ref42","unstructured":"human C-reactive protein suppresses endothelial nitric oxide"},{"key":"ref43","unstructured":"synthase expression and bioactivity after vascular injury. Am"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"J Physiol Heart Circ Physiol. 2007; 293: H489\u2013H495.","DOI":"10.1152\/ajpheart.01418.2006"},{"key":"ref45","unstructured":"Brault S, Gobeil F, Fortier A, Honore\u00b4 JC, Joyal JS, Sapieha"},{"key":"ref46","unstructured":"P, et al. Lysophosphatidic acid induces endotelial cell death"},{"key":"ref47","unstructured":"by modulating redox environment. American Journal of Physiology-Regulation and Integrative Physiology. 2007; 292:"},{"key":"ref48","unstructured":"R1174-R1183."},{"key":"ref49","unstructured":"Handa O, Stephen J and Cepinskas G.Role of endothelial"},{"key":"ref50","unstructured":"nitric oxide synthase-derived nitric oxide in activation and"},{"key":"ref51","unstructured":"dysfunction of cerebrovascular endothelial cells during early"},{"key":"ref52","unstructured":"onsets of sepsis. Am J Physiol Heart Circ Physiol. 2008; 295:"},{"key":"ref53","unstructured":"H1712\u2013H1719."},{"key":"ref54","unstructured":"del Riesgo L, y Soto K. Efecto neuroprotector de la L-arginina y la N-acetilciste\u00edna en ratas durante la hipoxia perinatal. Revista Cient\u00edfica. 2004; (6): 225-234."},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Jenkins D, Chang E Singh I. Neuroprotective Interventions: Is it too late? 2009; 24: 1212-1219.","DOI":"10.1177\/0883073809338412"},{"key":"ref56","unstructured":"Woldesenbet M, Rosenfeld C R , Ramilo O, Johnson-Welch"},{"key":"ref57","unstructured":"S, Perlman JM .Severe neonatal hypoxic respiratory failure"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"correlates with histological chorioamnionitis and raised concentrations of interleukin 6 (IL6), IL8 and C-reactive protein.","DOI":"10.1136\/adc.2007.124503"},{"key":"ref59","unstructured":"Arch. Dis Child. Fetal Neonatal. 2008; 93: 413-417."},{"key":"ref60","unstructured":"Clasificaci\u00f3n Internacional de Enfermedades (CIE-10): 16."},{"key":"ref61","unstructured":"Enfermedades del feto y del reci\u00e9n nacido 16 P00-P96. Disponible en: https:\/\/goo.gl\/V71KaJ."},{"key":"ref62","unstructured":"Mendieta, E; Bataglia, V; Mir R; C\u00e9spedes E; Mart\u00ednez C;"},{"key":"ref63","unstructured":"Caballero C. Morbimortalidad Neonatal en tres centros hospitalarios de referencia: an\u00e1lisis de los indicadores del sistema inform\u00e1tico perinatal. Pediatr\u00eda Py 2004; 31 (2): 83-7."},{"key":"ref64","unstructured":"Zuleta JJ, G\u00f3mez JG, Jaramillo DC. An\u00e1lisis poblacional de"},{"key":"ref65","unstructured":"la mortalidad perinatal. Universidad de Antioquia. 115-133."},{"key":"ref66","unstructured":"Disponible en: http:\/\/200.24.17.24:10039\/wps\/wcm\/connect\/"},{"key":"ref67","unstructured":"udea\/242fe9b7-8ce3-4fab-b3fc-e44c49e5bf5c\/0610-analisis-"},{"key":"ref68","unstructured":"poblacional-mp.pdf?MOD=AJPERES&attachment=-"},{"key":"ref69","unstructured":"true&id=1449102443151."},{"key":"ref70","unstructured":"Alejandro AH. Eficiencia hospitalaria y calidad en la atenci\u00f3n"},{"key":"ref71","unstructured":"perinatal de ESSALUD: \u00bfSer eficiente salva vidas? Informe"},{"key":"ref72","unstructured":"Parcial Universidad de Piura, Per\u00fa (2009). CIES Consorcio"},{"key":"ref73","unstructured":"de investigaci\u00f3n Econ\u00f3mica y Social. Agosto de 2009. 16 pp."},{"key":"ref74","unstructured":"Aspectos destacados de las gu\u00edas de la American Heart Association de 2010 para RCP y ACE. American Heart Association. 2010. Disponible en: https:\/\/goo.gl\/95w4Wq."},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"The Apgar Score American Academy of Pediatrics, 2006. Pediatrics, Vol: 117\/ Issue 4.Disponible en: pediatrics.aappublications.org\/content\/117\/4\/1444.","DOI":"10.1542\/peds.2006-0325"},{"key":"ref76","unstructured":"Jeffrey M. Perlman. Intrapartum Hypoxic-Ischemic Cerebral"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Injury and Subsequent Cerebral Palsy: Medicolegal Issues.","DOI":"10.1542\/peds.99.6.851"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"Pediatrics. 1997; 99:851-859.","DOI":"10.1542\/peds.99.6.851"},{"key":"ref79","unstructured":"Goldenberg R,Huddleenton J F and Nelson K.:Apgar score"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"and umbilical pH in preterm newborn infants. Am J Obstet.","DOI":"10.1016\/0002-9378(84)90251-5"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Gynecol 1984. 149:651-653.","DOI":"10.1093\/infdis\/149.4.651"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Bashambu MT, Whitehead H, Hibbs AM, Martin RJ and Bhola M. Evaluation of Interobserver Agreement of Apgar Scoring in Preterm Infants. Pediatrics 2012; 130:e982\u2013e987","DOI":"10.1542\/peds.2012-0368"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Catlin E, Marshall C, Brann B. The Apgar score revisited: influence of gestational age. J Pediatr. 1986; 109:865-868.","DOI":"10.1016\/S0022-3476(86)80715-6"},{"key":"ref84","unstructured":"D'Souza SW, Black P and Cadman J.Umbilical venous blood"},{"key":"ref85","unstructured":"pH:a useful aid in the diagnosis of asphyxia at birth. Arch.Dis"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Child. 1983; 38:15-19.","DOI":"10.1002\/cd.23219831904"},{"key":"ref87","unstructured":"H\u00fcbner ME, Ram\u00edrez RA, Mu\u00f1oz H. Asfixia neonatal evaluada a trav\u00e9s del test de apgar y ph de vena umbilical. Rev."},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"Pediatr 1991; 34:166-170.","DOI":"10.1179\/pom.1991.34.3.170"},{"key":"ref89","unstructured":"Sykes GS, Jonhnson P, Ashworth F et al. Do Apgar score"},{"key":"ref90","unstructured":"indicate asphyxia? Lancet 1982; 1:494-496."},{"key":"ref91","unstructured":"Riley R,Johnson JW. Collecting and Analyzing Cord Blood"},{"key":"ref92","doi-asserted-by":"crossref","unstructured":"gases. Clin Obstet Gynecol. 1993; 36:13-23.","DOI":"10.1097\/00003081-199303000-00005"},{"key":"ref93","unstructured":"Laptook AR, Shankaran S, Ambalavanan N, Carlo WA, Mc-"},{"key":"ref94","unstructured":"Donald SA, Higgins RD and Das A. Outcome of Term Infants"},{"key":"ref95","unstructured":"Using Apgar Scores at 10 Minutes Following Hypoxic-Ischemic"},{"key":"ref96","doi-asserted-by":"crossref","unstructured":"Encephalopathy. Pediatrics 2009; 124:1619-1626.","DOI":"10.1542\/peds.2009-0934"},{"key":"ref97","unstructured":"Avaiable from: http:\/\/pediatrics.aappublications.org\/content\/"},{"key":"ref98","unstructured":"\/6\/1619.full.html"},{"key":"ref99","unstructured":"Zulfiqar A, Bhutta G L, Darmstadt, Hasan BS and Haws RA."},{"key":"ref100","doi-asserted-by":"crossref","unstructured":"Community-Based Interventions for Improving Perinatal and","DOI":"10.1542\/peds.2004-1441"},{"key":"ref101","unstructured":"Neonatal Health Outcomes in Developing Countries: A Review"},{"key":"ref102","doi-asserted-by":"crossref","unstructured":"of the Evidence. Pediatrics 2005; 115: 519-617.","DOI":"10.1542\/peds.2004-1441"},{"key":"ref103","doi-asserted-by":"publisher","unstructured":"Lai MCH y Yang S-H. Perinatal. Hypoxic-Ischemic Encephalopathy. Journal of Biomedicine and Biotechnology 2011. Article ID 609813: 1-6 doi:10.1155\/2011\/609813.","DOI":"10.1155\/2011\/609813"},{"key":"ref104","unstructured":"Sutton PS, and Darmstadt GL. Preterm Birth and Neurodevelopment: A Review of Outcomes and Recommendations for Early Identification and Cost-effective Interventions. Journal of Tropical Pediatrics. (2013). Downloaded from https:\/\/goo.gl\/Mr1rh3."}],"container-title":["Revista de Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/viewFile\/65204\/64265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/viewFile\/65204\/64265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T22:11:15Z","timestamp":1751235075000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/view\/65204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,1]]},"references-count":104,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,5,1]]}},"URL":"https:\/\/doi.org\/10.15446\/rsap.v19n3.65204","relation":{},"ISSN":["2539-3596","0124-0064"],"issn-type":[{"type":"electronic","value":"2539-3596"},{"type":"print","value":"0124-0064"}],"subject":[],"published":{"date-parts":[[2017,5,1]]}}}