{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:14:53Z","timestamp":1710288893819},"reference-count":35,"publisher":"Universidad Nacional de Colombia","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. salud p\u00fablica"],"abstract":"<jats:p>Objetivo Determinar la actividad en suero de CK y CK-MB en pacientes con dengue.M\u00e9todos Se realiz\u00f3 un estudio de corte en el Departamento de Antioquia. La poblaci\u00f3n de estudio estuvo constituida por 54 pacientes con diagn\u00f3stico de dengue y por 10 controles sanos. A todos los participantes se les tom\u00f3 muestra de suero para confirmar la infecci\u00f3n por dengue y para hacer la medici\u00f3n de la actividad de CK y CK-MB.Resultados La mediana de la edad de los casos de dengue fue 18 a\u00f1os y la de los controles fue 28,5 a\u00f1os. La mitad de los pacientes con dengue (50,9 %) y ninguno del grupo control presentaron CK-MB elevada. Ning\u00fan paciente present\u00f3 miocarditis, sin embargo, se observ\u00f3 CK-MB elevada en 33,3 %, 44,4 % y 40 % de los casos con bradicardia, taquicardia e hipotensi\u00f3n respectivamente. En 29,6 % de los pacientes con dengue se detect\u00f3 CK elevada, en contraste con 10 % en el grupo control. Se observ\u00f3 actividad de CK en pacientes con dengue con presencia de s\u00edntomas como v\u00f3mito, hematemesis y dolor abdominal, 87,5 %, 60 % y 50 % respectivamente.Conclusiones En este estudio ning\u00fan paciente con dengue present\u00f3 cardiopat\u00eda o miositis, sin embargo, el hecho de encontrar mayor frecuencia de CK y CK-MB elevadas en los pacientes con dengue con respecto al grupo control, sugiere compromiso del m\u00fasculo estriado y card\u00edaco en este grupo. Por esta raz\u00f3n ser\u00eda pertinente el monitoreo de estas enzimas en pacientes con dengue como parte de la evoluci\u00f3n de la enfermedad.<\/jats:p>","DOI":"10.15446\/rsap.v19n4.39597","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T21:18:37Z","timestamp":1523308717000},"page":"460-467","source":"Crossref","is-referenced-by-count":4,"title":["Actividad en suero de CK y CK-MB en pacientes con infecci\u00f3n por el virus dengue"],"prefix":"10.15446","volume":"19","author":[{"given":"Ivony Yireth","family":"Agudelo Salas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nini","family":"Quiceno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Duque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta Nelly","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6146","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL et al. 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