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La resistencia debe sospecharse y diagnosticarse tempranamente para evitar la progresi\u00f3n de la enfermedad; los criterios cl\u00ednicos y paracl\u00ednicos ayudan a su confirmaci\u00f3n diagn\u00f3stica, en los estudios bacteriol\u00f3gicos la escala semicuantitativa Colombiana debe reemplazarse por escala logar\u00edtmica de Ridley y Jopling, los estudios histopatol\u00f3gicos se practican en todo paciente con enfermedad de Hansen, los estudios de resistencia se est\u00e1n implementando en el pa\u00eds pero su acceso limita oportunidad para apoyo en el inicio terap\u00e9utico.<\/jats:p>","DOI":"10.15446\/rsap.v19n6.63359","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T20:16:32Z","timestamp":1529698592000},"page":"814-817","source":"Crossref","is-referenced-by-count":0,"title":["Resistencia a la poliquimioterapia en pacientes con enfermedad de Hansen"],"prefix":"10.15446","volume":"19","author":[{"given":"Diego Andres","family":"Vasquez-Lesmes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Milena","family":"Cuevas-Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Faizal-Geagea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6146","published-online":{"date-parts":[[2017,11,1]]},"reference":[{"key":"ref1","unstructured":"Instituto Nacional de Salud. Protocolo de vigilancia en salud publica lepra. Pro- R02.017 2016; 1-31."},{"key":"ref2","unstructured":"World health organization. Global leprosy update, 2015: time for action, accountability and inclusion. Weekly epidemiological record. 2016; 35 (91): 405-420."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Han XY1, Sizer KC, Velarde-F\u00e9lix JS, Frias-Castro LO, Vargas-Ocampo F. The leprosy agents Mycobacterium lepromatosis and Mycobacterium leprae in Mexico. Int J Dermatol. 2012; 51: 952\u2013959.","DOI":"10.1111\/j.1365-4632.2011.05414.x"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Colorado C, S\u00e1nchez G, Guerrero M, Le\u00f3n C. Confiabilidad y concordancia de dos escalas de lectura de baciloscopias para clasificaci\u00f3n y seguimiento del tratamiento con m\u00faltiples medicamentos de los pacientes con lepra. Biom\u00e9dica. 2013: 31: 403-9.","DOI":"10.7705\/biomedica.v31i3.383"},{"key":"ref5","unstructured":"World Health Organization. Surveillance of drug resistance in leprosy: 2010. Wkly Epidemiol Rec. 2013; 86 (23): 237-240."},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Beltr\u00e1n-Alzate C, L\u00f3pez D\u00edas F, Romero-Montoya M, Sakamuri R, Kimura M, Brennan P, Cardona-Castro N. Leprosy Drug Resistance Surveillance in Colombia: The experience of a sentinel country. PLoS Negl Trop Dis. 2016; 10 (10): e0005041.","DOI":"10.1371\/journal.pntd.0005041"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Kar HK, Gupta R. Treatment of leprosy. Clinics in Dermatology. 2015; 33(1): 55-65.","DOI":"10.1016\/j.clindermatol.2014.07.007"},{"key":"ref8","unstructured":"World Health Organization. Guidelines for Global Surveillance of Drug Resistance in Leprosy. SEA-GLP-2009.2."},{"key":"ref9","unstructured":"Instituto Lauro de Souza Lima, Coordenadoria de Controle de Doencas, Secretaria de estado da Sa\u00fade. Relapse and drug resistance in leprosy. Rev Sa\u00fade P\u00fablica. 2013; 45 (3): 631-3."},{"key":"ref10","unstructured":"Hernandez E, Cardona N, Rodriguez G, Villegas S, Beltran C, Kimura M, Vissa VD, Gomez Y. Study of rifampin and dapsone resistance in three patients with recurring leprosy. Rev Panam Salud Publica. 2008; 23(2): 73\u20137."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Cambau E, Chauffour-Nevejans A, Tejmar-Kolar L, Matsuoka M, Jarlier M. Detection of Antibiotic Resistance in Leprosy Using GenoType LepraeDR, a Novel Ready-To-Use Molecular Test. PLoS Negl Trop Dis. 2012; 6(7): e 1739.","DOI":"10.1371\/journal.pntd.0001739"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Guerrero MI, Colorado CL, Torres JF, Le\u00f3n CI. Is drug-resistant Mycobacterium leprae a real cause for concern? First approach to molecular monitoring of multibacillary Colombian patients with and without previous leprosy treatment. 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