{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:14:54Z","timestamp":1710288894633},"reference-count":27,"publisher":"Universidad Nacional de Colombia","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. salud p\u00fablica"],"abstract":"<jats:p>Objetivos Describir las caracter\u00edsticas epidemiol\u00f3gicas, cl\u00ednicas y el tratamiento de ni\u00f1os con leishmaniasis visceral en Neiva, Huila.Metodolog\u00eda Se realiz\u00f3 un estudio descriptivo del brote de leshmaniasis visceral en ni\u00f1os de la zona urbana de Neiva, Huila, entre los meses de abril a junio de 2012.Resultados Se presentaron siete casos, en ni\u00f1os menores de cinco a\u00f1os, con fiebre prolongada, hepato-esplenomegalia, anemia severa y leucopenia. Cinco ingresaron con trombocitopenia severa, sin manifestaciones hemorr\u00e1gicas. Seis pacientes recibieron manejo de primera l\u00ednea con miltefosine, cinco presentaron fracaso terap\u00e9utico y se escalon\u00f3 tratamiento a anfotericina B, de los cuales dos recibieron anfotericina liposomal y tres anfotericina deoxicolato. El principal vector identificado fue la Lutzomyia gomezi y los reservoirios indentifiacados fueron caninos.Conclusi\u00f3n Se describe el primer brote de leishmaniasis visceral en zona urbana, en poblaci\u00f3n pedi\u00e1trica sin casos de mortalidad. La mayor\u00eda de los casos con buena respuesta a Anfotericina B.<\/jats:p>","DOI":"10.15446\/rsap.v20n1.47135","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T20:34:22Z","timestamp":1531773262000},"page":"89-93","source":"Crossref","is-referenced-by-count":1,"title":["Brote urbano de leishmaniasis en Colombia"],"prefix":"10.15446","volume":"20","author":[{"given":"Hern\u00e1n","family":"Manotas-Berdugo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica Fernanda","family":"Toro Maldonado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jairo","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Salgado-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6146","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"ref1","unstructured":"Palatnik C, Day M. One Health: the global challenge of epidemic and endemic leishmaniasis. Parasites & vectors. Biomed Central. 2011; 4(1): 197."},{"key":"ref2","unstructured":"Bennett J, Dolin R, Blaser M. Principles and Practice of Infectious Diseases. Elsevier. Seventh ed. New York. 2010. 2, 463-3480."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Bogdan C, Gessner A. Cytokines in leishmaniasis: a complex network of stimulatory and inhibitory interactions. Immunobiology.1993; 189(3-4): 356-396.","DOI":"10.1016\/S0171-2985(11)80366-9"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Oliveira J, Fernandes A. Mortality due to visceral leishmaniasis: clinical and laboratory characteristics. Rev. Soc. Bras. Med. Trop. 2010; 43(2): 188-193.","DOI":"10.1590\/S0037-86822010000200016"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Van Griensven J, Diro E. Visceral leishmaniasis. Infect Dis Clin North Am. 2012; 26(2): 309-322.","DOI":"10.1016\/j.idc.2012.03.005"},{"key":"ref6","unstructured":"Maia A, Carmo E. Analysis of visceral leishmaniasis reports by the capture-recapture method. Revista de sa\u00fade p\u00fablica. 2007; 41(6): 931-937."},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Alvar J, Velez I, WHO Leishmaniasis Control Team. Leishmaniasis worldwide and global estimates of its incidence. PloS one. 2012; 7(5): e35671.","DOI":"10.1371\/journal.pone.0035671"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"De Queiroz S, Cavalcanti N, Alves J, Fernandes F. Risk factors for death in children with visceral leishmaniasis. PLoS Negl Trop Dis. 2010; 4(11): e877.","DOI":"10.1371\/journal.pntd.0000877"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Romero G, Boelaert M. Control of visceral leishmaniasis in Latin America\u2014a systematic review. PLoS Negl Trop Dis. 2010; 4(1): e584.","DOI":"10.1371\/journal.pntd.0000584"},{"key":"ref10","unstructured":"Rojas D. Gu\u00eda de Atenci\u00f3n integral del paciente con leishmaniasis. Social MdP, editor. Bogot\u00e1; 2010. p. 1-58."},{"key":"ref11","unstructured":"Echeverry M, Gaona J, Gualtero S. Gu\u00eda de atenci\u00f3n de la leishmaniasis. Ministerio de Salud \u2013 Direcci\u00f3n General de Promoci\u00f3n y Prevenci\u00f3n. 2012. [Internet]. Disponible em: https:\/\/bit.ly\/2Ld56FQ."},{"key":"ref12","unstructured":"Pinz\u00f3n H, Orta C, P\u00e9rez C. Leishmaniasis visceral y cut\u00e1nea en zona urbana de Cartagena, Colombia: reporte de un caso. Rev cienc biomed. 2012; 3 (1): 149-154."},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Rijal S, Chappuis F, Singh R. Treatment of visceral leishmaniasis in south-eastern Nepal: decreasing efficacy of sodium stibogluconate and need for a policy to limit further decline. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2003; 97(3): 350-354.","DOI":"10.1016\/S0035-9203(03)90167-2"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"De Ara\u00fajo V, Pinheiro L, De Mattos A , De Menezes F. Relative risk of visceral leishmaniasis in Brazil: a spatial analysis in urban area. PLoS Negl Trop Dis. 2013; 7(11): e2540.","DOI":"10.1371\/journal.pntd.0002540"},{"key":"ref15","unstructured":"V\u00e1zquez C. Caracter\u00edsticas epidemiol\u00f3gicas y cl\u00ednicas de la Leishmaniasis visceral en un servicio de pediatr\u00eda. Pediatr\u00eda (Asunci\u00f3n). 2017; 37(3): 175-180."},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Gama M, Gomes C, Silveira F, Laurenti M. Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features. Rev Soc Bras Med Trop. 2013; 46(6): 741-745.","DOI":"10.1590\/0037-8682-0203-2013"},{"key":"ref17","unstructured":"Salgado D, Panqueva C, Rodr\u00edguez J. Leishmaniasis visceral en ni\u00f1o: afecta principalmente a menores de dos a\u00f1os. Revisi\u00f3n de 20 a\u00f1os de experiencia. Pediatr\u00eda (Bogot\u00e1). 1998; 33(3): 160-5."},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Gama M, Costa J, Gomes C. Subclinical form of the American visceral leishmaniasis. Mem\u00f3rias do Instituto Oswaldo Cruz. 2004; 99(8): 889-893.","DOI":"10.1590\/S0074-02762004000800018"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Braga A., Toledo J. Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005. Rev Soc Bras Med Trop. 2013; 46(1): 55-59.","DOI":"10.1590\/0037-868216432013"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"De Ara\u00fajo V, Morais M. Early clinical manifestations associated with death from visceral leishmaniasis. PLoS Negl Trop Dis. 2012; 6(2): e1511.","DOI":"10.1371\/journal.pntd.0001511"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Guerin P, Olliaro P, Sundar S. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. The Lancet infectious diseases. 2002; 2(8): 494-501.","DOI":"10.1016\/S1473-3099(02)00347-X"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Srividya G, Kulshrestha A, Singh R. Diagnosis of visceral leishmaniasis: developments over the last decade. Parasitology research. 2012; 110(3): 1065-1078.","DOI":"10.1007\/s00436-011-2680-1"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Ostyn B, Hasker E, Dorlo T. Failure of miltefosine treatment for visceral leishmaniasis in children and men in South-East Asia. PLoS One. 2014; 9(6): e100220.","DOI":"10.1371\/journal.pone.0100220"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Salih N, Griensven J, Chappuis F.Liposomal amphotericin B for complicated visceral leishmaniasis (kala-azar) in eastern Sudan: how effective is treatment for this neglected disease?. Tropical Medicine & International Health. 2014; 19(2): 146-152.","DOI":"10.1111\/tmi.12238"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Croft S, Sundar S. Drug resistance in leishmaniasis. Clinical microbiology reviews. 2006; 19(1): 111-126.","DOI":"10.1128\/CMR.19.1.111-126.2006"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Saravolatz L, Bern C. Liposomal amphotericin B for the treatment of visceral leishmaniasis. Clinical Infectious Diseases. 2006; 43(7): 917-924.","DOI":"10.1086\/507530"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez C, Cabrera O, Munstermann L. Distribution of Leishmania infantum vector species in Colombia. Biom\u00e9dica. 2006; 26: 64-72.","DOI":"10.7705\/biomedica.v26i1.1501"}],"container-title":["Revista de Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/viewFile\/47135\/66627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/viewFile\/47135\/66627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T17:34:47Z","timestamp":1710264887000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/view\/47135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.15446\/rsap.v20n1.47135","relation":{},"ISSN":["2539-3596","0124-0064"],"issn-type":[{"value":"2539-3596","type":"electronic"},{"value":"0124-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1,1]]}}}