{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:19:43Z","timestamp":1710289183086},"reference-count":19,"publisher":"Universidad Nacional de Colombia","issue":"6","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. salud p\u00fablica"],"abstract":"<jats:p>Objetivos Determinar el efecto del consumo del extracto de alfalfa en anemia ferrop\u00e9nica inducida, en ratones.Materiales y M\u00e9todos Se utilizaron treinta ratones albinos M. musculus de la cepa Balb\/c, machos de peso promedio 23\u00b133,7 g. Se formaron tres grupos de diez ratones cada uno: a) grupo control negativo hierro suficiente (HS), recibi\u00f3 40g\/d de alimento balanceado durante siete semanas; b) grupo control positivo hierro deficiente (HD), recibi\u00f3 40g\/d de dieta ferrop\u00e9nica durante siete semanas y; c) grupo experimental hierro deficiente (HD), recibi\u00f3 40g\/d de dieta ferrop\u00e9nica durante siete semanas y a partir de la semana cinco se agreg\u00f3 20g\/d de extracto de alfalfa (EA).Resultados Al finalizar el tratamiento se observ\u00f3 diferencia significativa en los niveles de hemoglobina entre los grupos control positivo (8.41\u00b13.9 g\/dL) y experimental (13.4\u00b13.3 g\/dL) (t student, p&lt;0,05). No se encontr\u00f3 diferencia significativa en los niveles de hemoglobina, al t\u00e9rmino del periodo de inducci\u00f3n entre los grupos control positivo (8.76\u00b13.9 g\/dL) y experimental (8.59\u00b1 3.1 g\/dL) (t student, p&gt;0,05).Conclusiones En condiciones experimentales, la alfalfa presenta efecto antian\u00e9mico, sustentado en los resultados de los niveles de hemoglobina.<\/jats:p>","DOI":"10.15446\/rsap.v20n6.65795","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T14:29:29Z","timestamp":1567607369000},"page":"737-741","source":"Crossref","is-referenced-by-count":0,"title":["Efecto del consumo del extracto de alfalfa (medicago sativa) en anemia ferrop\u00e9nica inducida, en ratones (mus musculus)"],"prefix":"10.15446","volume":"20","author":[{"given":"Jony Z.","family":"Amaro-Terrazos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda E.","family":"Iparraguirre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela C.","family":"Isla-Ponciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6146","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"ref1","unstructured":"WHO (Organizaci\u00f3n Mundial de la Salud, GE). Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia \/ Edited by Bruno de Benoist, Erin McLean, Ines Egli and Mary Cogswell. Ginebra. 2008. Consultado 13 jun. 2013. Disponible Disponible http:\/\/bit.ly\/2HY5NSS ."},{"key":"ref2","unstructured":"WHO (Organizaci\u00f3n Mundial de Salud, GI). Concentraciones de hemoglobina para evaluar la anemia y diagnosticar su gravedad. 2011. Ginebra. WHO\/NMH\/NHD\/MNM\/11.1. Consultado 18 jul. 2014. Disponible: Disponible: http:\/\/bit.ly\/2X9Ur4i ."},{"key":"ref3","unstructured":"Madrid A. Gu\u00eda pr\u00e1ctica de nutrici\u00f3n y diet\u00e9tica. Un tratado completo, moderno y pr\u00e1ctico de nutrici\u00f3n y diet\u00e9tica en un solo libro. AMV ediciones. 1 ed. Espa\u00f1a; 360 p. 2012."},{"key":"ref4","unstructured":"Grandy G, Weisstaub G, L\u00f3pez D. Deficiencia de hierro y zinc en ni\u00f1os. Rev. Soc. Bol. Ped. 2010:49 (1): 25-31."},{"key":"ref5","unstructured":"WHO (Organizaci\u00f3n Mundial de Salud, GI). Concentraciones de hemoglobina para evaluar la anemia y diagnosticar su gravedad. Ginebra. 2011. WHO\/NMH\/NHD\/MNM\/11.1. Consultado 18 jul. 2014. Disponible en: Disponible en: http:\/\/bit.ly\/2M7E7jt ."},{"key":"ref6","unstructured":"Cap\u00edtulo Vi Cultivos para Heno - Leguminosas Forrajeras y Legumbres. [ Internet]. ROMA: Departamento de Agricultura; 2003 [citado 12 jun 2017]. Disponible en: Disponible en: http:\/\/bit.ly\/2W80zhg ."},{"key":"ref7","unstructured":"Garcia Hernandez, Y, Morejon Calderon A, Bourg Llamo, V. Efecto oxidativo de la anemia ferrop\u00e9nica severa en ratas Wistar machos reci\u00e9n destetadas. Rev Cubana Invest Biom\u00e9d [online]. 2015; 34(1) 44-53."},{"key":"ref8","unstructured":"Ciriaco A, Mendiola J, Falcon D, Cantillo J. Obtenci\u00f3n de Sangre e Inyecci\u00f3n Intravenoso en Roedores por v\u00eda de la vena safena. Instituto \"Pedro Kour\u00ed\". (IPK) Cuba. Disponible en : http:\/\/bit.ly\/2wkII7."},{"key":"ref9","unstructured":"Pontificia Universidad Javeriana, Bogot\u00e1. Procedimiento de Administraci\u00f3n de Sustancias y Toma de Muestras Sangu\u00edneas Incluyendo Rutas y Volumenes en Roedores DE Laboratorio [Internet] Consultado en junio 17 de 2017. Disponible: Disponible: http:\/\/bit.ly\/2VV4jh8 ."},{"key":"ref10","unstructured":"Comit\u00e9 de \u00c9tica de Experimentaci\u00f3n Animal (CEEA\/AAEB). \u00c9tica en la investigaci\u00f3n con animales. Disponible en: http:\/\/bit.ly\/2woBmjq."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Pico FSM, Guti\u00e9rrez D, Arag\u00f3n GI, Escobar SA, Ortiz D, S\u00e1nchez T, Imbach\u00ed NP, Pach\u00f3n H. Evaluaci\u00f3n de la Composici\u00f3n Nutricional, Antinutricional y Biodisponibilidad In Vitro de Diferentes Extractos Foliares Rev Chil Nutr. 2011;38(2): 168-176","DOI":"10.4067\/S0717-75182011000200007"},{"key":"ref12","unstructured":"Cosgrove DJ, Irving GCJ. Inositol Phosphates: Their Chemistry, Biochemistry and Physiology, Elsevier, Amsterdam, The Netherlands. 1980"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Hurrell RF, Lynch S, Bothwell T, Cori H, Glahn R, Hertrampf E, Kratky Z, Miller D, Rodenstein M, Streekstra H, Teucher B, Turner E, Yeung CK and Zimmermann MB. Enhancing the Absorption of Fortification Iron A SUSTAIN Task Force Report C.K C.K Int. J. Vitam. Nutr. Res., 74 (6), 2004, 387-401.","DOI":"10.1024\/0300-9831.74.6.387"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Simpson CJ, Wise A. Binding of zinc and calcium to inositol phosphates (phytate) in vitro. Br. J. Nutr.1990;64(1): 225-232.","DOI":"10.1079\/BJN19900024"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Hallberg L, Brune M, Rossander L. Iron absorption in man: ascorbic acid and dose dependent inhibition by phytate. Am J Clin Nutr. 1989 ;49(1):140-4.","DOI":"10.1093\/ajcn\/49.1.140"},{"key":"ref16","unstructured":"Pennacchiotti Monti PI, Yanssens Guti\u00e9rrez G. Valoraciones Espectro-fotometrica de la Vitamina C en Alfalfa , Heno de Alfalfa y Trebol y de Caroteno en Trebol. Agricultura T\u00e9cnica Chile.1953; 15 (1): 27-30."},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Davidsson L, Walczyk T, Zavaleta N, Hurrell R. Improving iron absorption from a Peruvian school breakfast meal by adding ascorbic acid or Na2EDTA Am J Clin Nutr. 2001 ;73(2):283-7.","DOI":"10.1093\/ajcn\/73.2.283"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Fernandez R, Phillips SF. Components of fiber impair iron absorption in the dog. Am J Clin Nutr. 1982 Jan;35(1):107-12.","DOI":"10.1093\/ajcn\/35.1.107"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Weber TK, Freitas Kde C, Amancio OM, de Morais MB. Effect of dietary fibre mixture on growth and intestinal iron absorption in rats re- covering from iron-deficiency anaemia. 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