{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:06:43Z","timestamp":1747199203468,"version":"3.40.5"},"reference-count":37,"publisher":"Universidad Nacional de Colombia","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. salud p\u00fablica"],"abstract":"<jats:p>Objetivo Descrever o perfil cl\u00ednico-epidemiol\u00f3gico dos portadores de fissuras orofaciais, atendidos em um Centro de Refer\u00eancia do Nordeste do Brasil.M\u00e9todos Estudo descritivo, baseado em dados secund\u00e1rios de prontu\u00e1rios m\u00e9dicos. Informa\u00e7\u00f5es sociodemogr\u00e1ficas do portador e da m\u00e3e, uso de medicamentos durante a gesta\u00e7\u00e3o, aspectos cl\u00ednicos e cir\u00fargicos relacionados \u00e0s fissuras, hist\u00f3rico familiar da malforma\u00e7\u00e3o e consanguinidade dos pais foram investigadas. Os dados foram analisados descritivamente, com o uso do programa estat\u00edstico SPSS (Statistical Package for te Social Sciences), no qual foram obtidas medidas de frequ\u00eancia, m\u00e9dia e desvio padr\u00e3o.Resultados 51,1% dos portadores de fissuras orofaciais eram do sexo feminino, 46,2% menores de um ano e 54,4% eram procedentes na zona urbana. A maioria das m\u00e3es encontrava-se na faixa et\u00e1ria entre 16 a 25 anos durante o per\u00edodo gestacional e relatou uso de medica\u00e7\u00e3o em 59,2% dos casos. A fissura transforame incisivo foi a mais diagnosticada (34,4%). No momento de cadastro ao Centro de Reabilita\u00e7\u00e3o de Anomalias Craniofaciais, 90,5% dos indiv\u00edduos ainda n\u00e3o haviam realizado tratamento cir\u00fargico. Hist\u00f3ria familiar de fissura foi observada em 29,8% dos casos estudados e em apenas 7,1% desses foi reportado consanguinidade entre os pais.Conclus\u00e3o Os fatores socioecon\u00f4micos e gen\u00e9ticos podem exercer influ\u00eancia sobre o desenvolvimento de fissuras orofaciais, o que exige uma maior aten\u00e7\u00e3o governamentalassim como novos estudos para melhor investiga\u00e7\u00e3o.\u00a0<\/jats:p>","DOI":"10.15446\/rsap.v21n2.74065","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T19:22:47Z","timestamp":1583781767000},"page":"209-216","source":"Crossref","is-referenced-by-count":1,"title":["Perfil cl\u00ednico-epidemiol\u00f3gico das fissuras orofaciais em um centro de refer\u00eancia do nordeste do Brasil"],"prefix":"10.15446","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4007-1762","authenticated-orcid":false,"given":"Jamille","family":"Rios-Moura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-8822","authenticated-orcid":false,"given":"Ana Paula","family":"Eufr\u00e1zio do Nascimento Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-265X","authenticated-orcid":false,"given":"Carlos Alberto","family":"Lima-Da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5793-3886","authenticated-orcid":false,"given":"Pedro Paulo","family":"De Andrade Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7259-4827","authenticated-orcid":false,"given":"Val\u00e9ria","family":"Souza-Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-7886","authenticated-orcid":false,"given":"Eduardo","family":"Costa-Das Merc\u00eas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6146","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"ref1","unstructured":"Moore KL, Persaud TVN, Torchia MG. 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