{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:09:44Z","timestamp":1754399384054,"version":"3.40.5"},"reference-count":29,"publisher":"Universidad Nacional de Colombia","issue":"5","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. salud p\u00fablica"],"abstract":"<jats:p>Objetivo El dengue es una enfermedad viral generalmente autolimitada, que en M\u00e9xico se considera un problema de salud p\u00fablica. Puede acompa\u00f1arse de alteraciones de laboratorio como neutropenia, linfopenia y trombocitopenia. El objetivo del estudio fue evaluar la incidencia de alteraciones hematol\u00f3gicas en pacientes con dengue.M\u00e9todos Se incluyeron retrospectivamente 64 pacientes, 14 embarazadas, con diagn\u00f3stico de dengue en los Hospitales Universitario de Monterrey y Civil Nuevo de Guadalajara, de enero de 2014 a diciembre de 2017.Resultados El dato cl\u00ednico m\u00e1s com\u00fan en el grupo general fue cefalea y dolor retroocular en 53 pacientes (83%), seguido de la fiebre, que se present\u00f3 en 12 pacientes embarazadas (86%). La mediana de cuenta plaquetaria en el grupo general fue de 51.4x103\/\u03bcl, adem\u00e1s, se encontr\u00f3 trombocitopenia en el 88% de los pacientes, mientras que en las pacientes embarazadas fue de 141.1 x103\/\u03bcl, con trombocitopenia en 57% de ellas (p=0.002). La recuperaci\u00f3n plaquetaria ocurri\u00f3 en 7 d\u00edas en el grupo general y 4.5 d\u00edas en las pacientes embarazadas.Conclusiones Contrario a lo reportado en la literatura, las pacientes embarazadas presentaron una menor incidencia de trombocitopenia y una mayor cuenta plaquetaria, al momento del diagn\u00f3stico sin impacto en mortalidad materna ni en el curso del embarazo.<\/jats:p>","DOI":"10.15446\/rsap.v21n5.76916","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T23:15:14Z","timestamp":1618874114000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Dengue durante el embarazo, menor incidencia de trombocitopenia que en la poblaci\u00f3n general"],"prefix":"10.15446","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-3633","authenticated-orcid":false,"given":"Cesar Homero","family":"Guti\u00e9rrez-Aguirre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-4876","authenticated-orcid":false,"given":"Alain","family":"Palomares-Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-1955","authenticated-orcid":false,"given":"Laura","family":"Soto Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-439X","authenticated-orcid":false,"given":"Perla","family":"Colunga Pedraza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6804-9095","authenticated-orcid":false,"given":"Jos\u00e9 Carlos","family":"Jaime P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9172-2951","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Zambrano Velarde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9715-9370","authenticated-orcid":false,"given":"Dante","family":"Vega Cortes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4302-9244","authenticated-orcid":false,"given":"Juan Antonio","family":"Flores Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0460-6427","authenticated-orcid":false,"given":"David","family":"G\u00f3mez-Almaguer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6146","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"1346500","unstructured":"Goldman L, Schafer AI. Tratado de Medicina Interna. Edicion 24. Barcelona, Elsevier; 2017."},{"key":"1346501","doi-asserted-by":"crossref","unstructured":"Rosso F, Pineda JC, Sanz AM, Cedano JA, Caicedo LA. Transmission of dengue virus from deceased donors to solid organ transplant recipients: case report and literature review. Braz J Infect Dis. 2018; 22(1):63-9. DOI:10.1016\/j.bjid.2018.01.001.","DOI":"10.1016\/j.bjid.2018.01.001"},{"key":"1346502","doi-asserted-by":"crossref","unstructured":"Yin X, Zhong X, Pan S. Vertical Transmission of Dengue Infection: The First Putative Case Reported in China. Rev Inst Med Trop Sao Paulo. 2016; 8:58-90. DOI:10.1590\/S1678-9946201658090.","DOI":"10.1590\/s1678-9946201658090"},{"key":"1346503","doi-asserted-by":"crossref","unstructured":"Chen LH, Wilson ME. Update on non-vector transmission of dengue: relevant studies with Zika and other flaviviruses. Trop Dis Travel Med Vaccines. 2016;2:15. DOI:10.1186\/s40794-016-0032-y.","DOI":"10.1186\/s40794-016-0032-y"},{"key":"1346504","doi-asserted-by":"crossref","unstructured":"Centers for Disease Control and Prevention (CDC). Dengue [Internet]. CDC; 2018 [cited 2018 Jul 1]. https:\/\/www.cdc.gov\/dengue\/.","DOI":"10.1007\/978-3-319-32001-4_258-1"},{"key":"1346505","doi-asserted-by":"crossref","unstructured":"Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496:504 7.","DOI":"10.1038\/nature12060"},{"key":"1346506","unstructured":"Organizac\u00f3n Mundial de la Salud (OMS). Dengue y dengue grave. [Internet]. Geneva: OMS; 2018 [cited 2018 Jul 1]."},{"key":"1346507","doi-asserted-by":"crossref","unstructured":"Torres I, Cortes D, Becker I. Dengue en M\u00e9xico: incremento en la poblaci\u00f3n juvenil durante la \u00faltima d\u00e9cada. Bol Med Hosp Infant Mex. 2014; 71(4):196-201. https:\/\/bit.ly\/37b7NDW.","DOI":"10.1016\/j.bmhimx.2014.08.003"},{"key":"1346508","doi-asserted-by":"crossref","unstructured":"Simmons CP, Farrar JJ, Nguyen VV, Wills B. Dengue. N Engl Med. 2012; 366(15):1423-32. DOI:10.1056\/NEJMra1110265.","DOI":"10.1056\/NEJMra1110265"},{"key":"1346509","unstructured":"Secretaria de Salud. Panorama Epidemiol\u00f3gico de Dengue [internet]. M\u00e9xico: Gobierno de M\u00e9xico; 2017 [cited 2018 Jul 1]. https:\/\/bit.ly\/3lgeSYJ."},{"key":"1346510","unstructured":"Centro Nacional de Excelencia Tecnol\u00f3gica en Salud. Gu\u00edas de Pr\u00e1ctica Cl\u00ednica. Clasificaci\u00f3n, diagn\u00f3stico y tratamiento integral del dengue. [Internet]. M\u00e9xico: Gobierno de M\u00e9xico. https:\/\/bit.ly\/3mqUCEY."},{"key":"1346511","unstructured":"World Health Organization (WHO). Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition [Internet]. Geneva: WHO; 2009 [cited 2019 Jul 27]. https:\/\/bit.ly\/2JeiRrr."},{"key":"1346512","doi-asserted-by":"crossref","unstructured":"Gan VC. Dengue: Moving from Current Standard of Care to State-of-the-Art Treatment. Curr Treat Options Infect Dis. 2014; 6(3):208-26. DOI:10.1007\/s40506-014-0025-1.","DOI":"10.1007\/s40506-014-0025-1"},{"key":"1346513","doi-asserted-by":"crossref","unstructured":"Kuo HJ, Lee IK , Liu JW. Analyses of clinical and laboratory characteristics of dengue adults at their hospital presentations based on the World Health Organization clinical-phase framework: Emphasizing risk of severe dengue in the elderly. J Microbiol Immunol Infect. 2017; S1684-1182(17)30067-1. DOI:10.1016\/j.jmii.2016.08.024.","DOI":"10.1016\/j.jmii.2016.08.024"},{"key":"1346514","doi-asserted-by":"crossref","unstructured":"Murillo-Zamora E, Medina-Gonz\u00e1lez A, Trujillo-Hern\u00e1ndez B, Mendoza-Cano O, Guzm\u00e1n-Esquivel J, Higareda-Almaraz M, et al. Clinical markers associated with acute laboratory-confirmed Dengue infection: results of a national epidemiological surveillance system. Rev. Salud P\u00fablica. (Bogot\u00e1) 2018; 19(6):744-8. DOI:10.15446\/rsap.v19n6.61823.","DOI":"10.15446\/rsap.v19n6.61823"},{"key":"1346515","doi-asserted-by":"crossref","unstructured":"Tewari K, Tewari VV, Mehta R. Clinical and Hematological Profile of Patients with Dengue Fever at a Tertiary Care Hospital - An Observational Study. Mediterr J Hematol Infect Dis. 2018;10(1):e2018021. DOI:10.4084\/MJHID.2018.021.","DOI":"10.4084\/mjhid.2018.021"},{"key":"1346516","unstructured":"Aroor AR, Saya RP, Sharma A, Venkatesh A, Alva R. Clinical Manifestations and Predictors of Thrombocytopenia in Hospitalized"},{"key":"1346517","doi-asserted-by":"crossref","unstructured":"Adults with Dengue Fever. N Am J Med Sci. 2015; 7(12):547-52. DOI:10.4103\/1947-2714.172841.","DOI":"10.4103\/1947-2714.172841"},{"key":"1346518","doi-asserted-by":"crossref","unstructured":"Changal KH, Raina AH , Raina A, Raina M, Bashir R , Latief M , et al. Differentiating secondary from primary dengue using IgG to IgM ratio in early dengue: an observational hospital based clinico-serological study from North India. BMC Infect Dis. 2016; 16:715. DOI:10.1186\/s12879-016-2053-6.","DOI":"10.1186\/s12879-016-2053-6"},{"key":"1346519","unstructured":"Rashmi MV, Hamsaveena. Haematological and biochemical markers as predictors of dengue infection. Malays J Pathol. 2015;37:247-51.PMID: 26712670."},{"key":"1346520","doi-asserted-by":"crossref","unstructured":"Bhaskar E, Sowmya G, Moorthy S, Sundar V. Prevalence, patterns,and factors associated with bleeding tendencies in dengue. J Infect Dev Ctries. 2015; 9(1):105-10. DOI: 10.3855\/jidc.5031.","DOI":"10.3855\/jidc.5031"},{"key":"1346521","doi-asserted-by":"crossref","unstructured":"Jayanthi HK, Tulasi SK. Correlation study between platelet count, leukocyte count, nonhemorrhagic complications, and duration of hospital stay in dengue fever with thrombocytopenia. J Family Med Prim Care. 2016; 5(1):120-123. DOI:10.4103\/2249-4863.184635.","DOI":"10.4103\/2249-4863.184635"},{"key":"1346522","doi-asserted-by":"crossref","unstructured":"Cabezas C, Fiestas V, Garc\u00eda-Mendoza M, Palomino M, Mamani E, Donaires F. Dengue en el Per\u00fa: a un cuarto de siglo de su reemergencia. Rev Peru Med Exp Salud P\u00fablica. 2015; 32(1):146-56. https:\/\/bit.ly\/3mfkIuN.","DOI":"10.17843\/rpmesp.2015.321.1587"},{"key":"1346523","doi-asserted-by":"crossref","unstructured":"Teixeira LAS, Nogueira FPDS, Nascentes GAN. Prospective study of patients with persistent symptoms of dengue in Brazil. Rev Inst Med Trop Sao Paulo. 2017; 4:e65. DOI:10.1590\/S1678-9946201759065.","DOI":"10.1590\/s1678-9946201759065"},{"key":"1346524","unstructured":"Jain S, Mittal A, Sharma SK, Upadhyay AD, Pandey RM, Sinha S, et al. Predictors of Dengue-Related Mortality and Disease Severity in a Tertiary Care Center in North India. Open Forum Infect Dis. 2017;4(2):ofx056. DOI:10.1093\/ofid\/ofx056."},{"key":"1346525","unstructured":"Kidwai AA, Riaz SU, Aatif S, Paracha S. Spontaneous platelet recovery time in primary and secondary dengue infection in a tertiary care hospital. J Pak Med Assoc. 2014; 64(12):1380-3. PMID: 25842582."},{"key":"1346526","unstructured":"Ron-Guerrero CS, L\u00f3pez-Flores F, Ron-Maga\u00f1a AL. Manifestaciones cl\u00ednicas y de laboratorio relacionadas con la recuperaci\u00f3n de las plaquetas en el dengue hemorr\u00e1gico. Medicina Universitaria. 2010; 12(46):11-7."},{"key":"1346527","doi-asserted-by":"crossref","unstructured":"Paixao ES, Harron K, Campbell O, Teixeira MG, Costa MDCN, Barreto ML, et al. Dengue in pregnancy and maternal mortality: a cohort analysis using routine data. Sci Rep. 2018; 8(1):9938. DOI:10.1038\/s41598-018-28387-w.","DOI":"10.1038\/s41598-018-28387-w"},{"key":"1346528","doi-asserted-by":"crossref","unstructured":"Cat\u00e3o Feitoza H, Koifman S, Jorge Koifman R, Saraceni V. Dengue infection during pregnancy and adverse maternal, fetal, and infant health outcomes in Rio Branco, Acre State, Brazil, 2007-2012. Cad Sa\u00fade P\u00fablica. 2017; 33(5):e00178915. DOI:10.1590\/0102-311x00178915.","DOI":"10.1590\/0102-311x00178915"}],"container-title":["Revista de Salud P\u00fablica"],"original-title":[],"link":[{"URL":"https:\/\/revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/download\/76916\/78405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/download\/76916\/78405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T23:17:06Z","timestamp":1618874226000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.unal.edu.co\/index.php\/revsaludpublica\/article\/view\/76916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,9,1]]}},"URL":"https:\/\/doi.org\/10.15446\/rsap.v21n5.76916","relation":{},"ISSN":["2539-3596","0124-0064"],"issn-type":[{"type":"electronic","value":"2539-3596"},{"type":"print","value":"0124-0064"}],"subject":[],"published":{"date-parts":[[2019,10,1]]}}}