{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:48:57Z","timestamp":1792144137771,"version":"4.4.0"},"reference-count":0,"publisher":"Armed Forces Medical Services","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saudi Medical Journal"],"abstract":"<jats:p>Objectives: To determine the frequency of rhabdomyolysis in patients hospitalized with COVID-19 and to characterize their clinical features and outcomes. Methods: All adults admitted to the hospital were included in this single-center retrospective cohort study with COVID-19 at a tertiary care institution in Alicante, Spain, between March 2020 and March 2024. A creatine kinase (CK) threshold of 1000 U\/L or higher was used to define rhabdomyolysis. Demographic, clinical, laboratory, treatment, and outcome data were collected. Patients with and without rhabdomyolysis were compared, and factors associated with in-hospital mortality (IHM) were analyzed. Results: Among 7,590 hospitalized COVID-19 patients, 20 developed rhabdomyolyses (cumulative incidence 0.26%; 95% CI 0.170.41). Most affected patients were male (85%), and male sex demonstrated an independent relationship with rhabdomyolysis (adjusted OR 4.35; 95% CI 1.2714.94). Acute kidney injury was observed in 60% of patients, and 15% required hemodialysis. IHM was markedly higher among patients with rhabdomyolysis than in those without (35% vs. 11.5%) (adjusted OR 4.24; 95% CI 1.4812.10). Conclusion: Rhabdomyolysis was an uncommon but severe complication of COVID-19, predominantly affecting men and frequently inked to acute kidney failure and high IHM.<\/jats:p>","DOI":"10.15537\/1658-3175.8794","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:32:43Z","timestamp":1778952763000},"page":"1095-1099","source":"Crossref","is-referenced-by-count":0,"title":["COVID-19\u2013Associated Rhabdomyolysis in Hospitalized Patients: &lt;i&gt;Retrospective Cohort Study&lt;\/i&gt;"],"prefix":"10.15537","volume":"47","author":[{"given":"Paula","family":"Esquerdo-Serrano","sequence":"first","affiliation":[{"name":"Pneumology Department, Dr. Balmis General University Hospital. Alicante Institute of Healthcare and Biomedical Research (ISABIAL), Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Otero-Rodriguez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Dr. Balmis General University Hospital. Alicante Institute of Healthcare and Biomedical Research (ISABIAL), Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Pinargote-Celorio","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Dr. Balmis General University Hospital. Alicante Institute of Healthcare and Biomedical Research (ISABIAL), Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Reus","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Dr. Balmis General University Hospital. Alicante Institute of Healthcare and Biomedical Research (ISABIAL), Alicante, Spain AND Clinical Medicine Department, Miguel Hern\u00e1ndez University of Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Merino","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Dr. Balmis General University Hospital. Alicante Institute of Healthcare and Biomedical Research (ISABIAL), Alicante, Spain AND Clinical Medicine Department, Miguel Hern\u00e1ndez University of Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Manuel","family":"Ramos-Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Dr. Balmis General University Hospital. Alicante Institute of Healthcare and Biomedical Research (ISABIAL), Alicante, Spain AND Clinical Medicine Department, Miguel Hern\u00e1ndez University of Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56029","published-online":{"date-parts":[[2026,5,14]]},"container-title":["Saudi Medical Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:26:50Z","timestamp":1792142810000},"score":1,"resource":{"primary":{"URL":"https:\/\/smj.researchcommons.org\/journal\/vol47\/iss6\/15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,5,14]]}},"URL":"https:\/\/doi.org\/10.15537\/1658-3175.8794","relation":{},"ISSN":["1658-3175"],"issn-type":[{"value":"1658-3175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]}}}