{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:48:54Z","timestamp":1792144134222,"version":"4.4.0"},"reference-count":0,"publisher":"Armed Forces Medical Services","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saudi Medical Journal"],"abstract":"<jats:p>Objective: To examine whether hematological and biochemical parameters assist in diagnosing cytomegalovirus (CMV) infections and differentiating between CMV-G and CMV-M. Cytomegalovirus causes distinct hematological changes that can serve as markers for diagnosis.\nMethods: A retrospective analysis was conducted on 54 patients infected with CMV (25 CMV-G and 29 CMV-M) and 82 healthy controls. Age, gender, and routine hematological and biochemical parameters were evaluated. Receiver operating characteristics (ROC) analysis and logistic regression were used for data analysis.\nResults: In comparison to controls, laboratory findings of patients with CMV-G revealed characteristic decreases in red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), and platelets (p &lt; 0.05); those with CMV-M showed reductions in the same parameters alongside elevation of monocytes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total iron-binding capacity (TIBC) and AST-to-platelet ratio index (APRI) (p &lt; 0.05). The most effective blood markers for differentiating CMV-G patients from controls were RBC, HGB, HCT, mean corpuscular hemoglobin (MCH), platelets, AST, ferritin, APRI and Fibrosis-4 (FIB-4) meanwhile, for CMV-M patients, distinguishing markers were RBC, HGB, HCT, MCH, monocytes, platelets, AST, TIBC, APRI and FIB-4. The best predictors for distinguishing CMV-M from CMV-G were TIBC, AST, HCT, monocytes, HGB, ALT, APRI and FIB-4 all with area under the curve values greater than 0.6 (p &lt; 0.05).\nConclusion: Hematological and biochemical indicators can successfully distinguish CMV infections, with TIBC, AST, HCT, monocytes, HGB, ALT, APRI and FIB-4 being potentially useful for discriminating CMV-M from CMV-G. These findings could help predict CMV-infected patients.<\/jats:p>","DOI":"10.15537\/1658-3175.8809","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:40:21Z","timestamp":1781455221000},"page":"1202-1209","source":"Crossref","is-referenced-by-count":0,"title":["A Predictive Model for Cytomegalovirus Infection Using Routine Hematological and Biochemical Parameters: &lt;i&gt;A Pilot Study&lt;\/i&gt;"],"prefix":"10.15537","volume":"47","author":[{"given":"Ahmad A.","family":"Shaikh","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mofareh H.","family":"Alabdaly","sequence":"additional","affiliation":[{"name":"Regional Laboratory of Jazan Health Cluster, Jazan, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil A.","family":"Ageeli","sequence":"additional","affiliation":[{"name":"Regional Laboratory of Jazan Health Cluster, Jazan, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan Z.","family":"Alasmari","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel M. Abo","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed H.","family":"Makkawi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56029","published-online":{"date-parts":[[2026,6,9]]},"container-title":["Saudi Medical Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:26:33Z","timestamp":1792142793000},"score":1,"resource":{"primary":{"URL":"https:\/\/smj.researchcommons.org\/journal\/vol47\/iss7\/12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":0,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,6,9]]}},"URL":"https:\/\/doi.org\/10.15537\/1658-3175.8809","relation":{},"ISSN":["1658-3175"],"issn-type":[{"value":"1658-3175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]}}}