{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:48:57Z","timestamp":1792144137779,"version":"4.4.0"},"reference-count":0,"publisher":"Armed Forces Medical Services","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saudi Medical Journal"],"abstract":"<jats:p>Non-diabetic chronic kidney disease (ND-CKD) complicated by resistant hypertension remains a high-risk phenotype even when renin\u2013angiotensin system blockade is optimized. This review synthesizes contemporary evidence for cardio-renal protection beyond traditional renin-angiotensin-aldosterone system inhibition (RAASi), with emphasis on mechanisms, clinical trial data, and pragmatic sequencing. Sodium\u2013glucose cotransporter 2 inhibitors provide hemodynamic and tubular benefits that translate into renal and heart failure risk reduction in many patients with ND-CKD. Non-steroidal mineralocorticoid receptor antagonism (MRA) like finerenone targets inflammatory and fibrotic signaling and may add incremental benefit when potassium is proactively managed. The GLP-1 receptor agonists offer cardiometabolic advantages with emerging kidney signals, particularly in patients with obesity and high cardiovascular risk. Modern potassium binders can preserve RAASi\/MRA intensity, and device-based blood pressure strategies (including renal denervation) may be considered in carefully selected resistant hypertension. We propose a stepwise implementation framework to maximize efficacy while minimizing adverse events through structured monitoring and multidisciplinary care.<\/jats:p>","DOI":"10.15537\/1658-3175.8819","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:25:31Z","timestamp":1783632331000},"page":"1277-1284","source":"Crossref","is-referenced-by-count":1,"title":["&lt;b&gt;Emerging Strategies for Cardio-Renal Protection Beyond RAAS Blockade: &lt;i&gt;Emphasis on Non-diabetic CKD and Resistant Hypertension&lt;\/b&gt;&lt;\/i&gt;"],"prefix":"10.15537","volume":"47","author":[{"given":"Fahad S.","family":"Alrashidi","sequence":"first","affiliation":[{"name":"Consultant, Internal Medicine\/Nephrology, Department of Medicine (Nephrology), Ad-Diriyah Hospital, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56029","published-online":{"date-parts":[[2026,7,6]]},"container-title":["Saudi Medical Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:26:25Z","timestamp":1792142785000},"score":1,"resource":{"primary":{"URL":"https:\/\/smj.researchcommons.org\/journal\/vol47\/iss8\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,6]]}},"URL":"https:\/\/doi.org\/10.15537\/1658-3175.8819","relation":{},"ISSN":["1658-3175"],"issn-type":[{"value":"1658-3175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]}}}