{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:48:45Z","timestamp":1792144125988,"version":"4.4.0"},"reference-count":0,"publisher":"Armed Forces Medical Services","issue":"10","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saudi Medical Journal"],"abstract":"<jats:p>Objectives: To describe the clinical profile of girls with central precocious puberty (CPP) and determine the factors associated with abnormal cranial magnetic resonance imaging (MRI) findings.Methods: This retrospective study included girls aged 8 years or younger with a diagnosis of CPP who received care at King Abdullah Specialized Children's Hospital in Riyadh, Kingdom of Saudi Arabia, between 2015 and 2023. Data on clinical presentation, biochemical results, imaging findings, and treatment were obtained from medical records. Logistic regression analysis was performed to determine variables associated with MRI utilization and the occurrence of abnormal MRI findings.Results: The cohort comprised 70 girls with CPP. The median age at breast development was 7.12 years, and pubertal onset occurred at \u22656 years in 84.3% of patients. Cranial MRI was obtained in 43 patients (61.4%), and abnormal findings were identified in 17 patients (24.3%). Pituitary gland enlargement (n = 6) and hypothalamic hamartoma (n = 4) were the most frequent abnormalities. Girls with a bone age-to-chronological age ratio &lt;1 year had lower odds of undergoing MRI (OR = 0.18, p-value = 0.009). Higher BMI z-scores were independently associated with abnormal MRI findings (OR = 1.95, p-value = 0.043). Other clinical and biochemical variables were not significantly associated with abnormal MRI results. GnRH analogue therapy was initiated in 81.4% of patients.Conclusion: Abnormal cranial MRI findings were identified in nearly one-quarter of girls with CPP. Higher BMI z-scores were associated with abnormal MRI findings, whereas age at puberty onset and other clinical variables did not reliably predict intracranial abnormalities.<\/jats:p>","DOI":"10.15537\/1658-3175.8855","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:20:46Z","timestamp":1790191246000},"page":"1657-1664","source":"Crossref","is-referenced-by-count":0,"title":["Cranial MRI in Girls With Central Precocious Puberty: Clinical Characteristics and Predictors of Abnormal Findings"],"prefix":"10.15537","volume":"47","author":[{"given":"Fahad N. Al","family":"Juraibah","sequence":"first","affiliation":[{"name":"Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; AND King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashael M.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem D.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; AND King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joud S.","family":"Albaraki","sequence":"additional","affiliation":[{"name":"Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; AND King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"AlDharman","sequence":"additional","affiliation":[{"name":"Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; AND King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala A.","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia AND King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagarajkumar","family":"Yenugadhati","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia AND College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah I.","family":"Alhammad","sequence":"additional","affiliation":[{"name":"Department of Radiology, King Abdullah Specialized Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angham N.","family":"Almutair","sequence":"additional","affiliation":[{"name":"Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; AND King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A. Al","family":"Alwan","sequence":"additional","affiliation":[{"name":"Pediatric Department, King Abdullah Specialist Children's Hospital, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; AND King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56029","published-online":{"date-parts":[[2026,9,14]]},"container-title":["Saudi Medical Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:25:26Z","timestamp":1792142726000},"score":1,"resource":{"primary":{"URL":"https:\/\/smj.researchcommons.org\/journal\/vol47\/iss10\/10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,14]]}},"URL":"https:\/\/doi.org\/10.15537\/1658-3175.8855","relation":{},"ISSN":["1658-3175"],"issn-type":[{"value":"1658-3175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]}}}