{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:02:21Z","timestamp":1792839741538,"version":"4.5.0"},"reference-count":0,"publisher":"Medical Communications Sp. z.o.o.","issue":"99","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Ultrason"],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:p>Aim: Chronic hepatitis C virus infections can lead to liver fibrosis. Appropriate treatment of chronic hepatitis C may result in significant fibrosis reversal. The best method to assess liver fibrosis is an invasive hepatic biopsy. Among non-invasive options, one of the most recent methods is two-dimensional shear- wave elastography, which allows real-time visualization of liver stiffness. The purpose of this study was to analyze changes in liver fibrosis among patients with hepatitis C virus receiving direct-acting antiviral therapy. Material and methods: Five different elastographic measurements in kilopascals were performed in a group of 50 patients before direct-acting antiviral treatment, at the end of treatment, and 24 weeks after the end of treatment, using an Aixplorer\u00ae (Supersonic Imagine, France) ultrasound device. The results were correlated with biochemical serum tests, specifically the Fibrosis-4 and AspAT-to-platelet ratio indices. Results: Time-dependent alterations of all of the parameters were observed, including a significant decrease in liver stiffness in comparison to baseline values (before treatment). A moderate correlation between liver stiffness measurement values and both Fibrosis-4 and AspAT-to-platelet ratio indices was observed. Interestingly, only liver stiffness and blood platelet count changed over time, regardless of the sex and age of the patient. Conclusions: Two-dimensional shear-wave elastography combined with non- invasive serologic tests like Fibrosis-4 and AspAT-to-platelet ratio indices is a sufficient tool for evaluating liver fibrosis regression during and after direct-acting antiviral therapy.<\/jats:p>","DOI":"10.15557\/jou.2024.0038","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T10:57:13Z","timestamp":1736765833000},"source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of liver fibrosis in HCV-infected patients using two-dimensional shear-wave elastography (2D-SWE) before and after antiviral treatment"],"prefix":"10.15557","volume":"24","author":[{"name":"Department of General and Pediatric Radiology, Wroc\u0142aw Medical University, Wroc\u0142aw, Poland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5477-1204","authenticated-orcid":false,"given":"Marcin","family":"Inglot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-2168","authenticated-orcid":false,"given":"Patryk","family":"Pozowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of General and Pediatric Radiology, Wroc\u0142aw Medical University, Wroc\u0142aw, Poland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-3676","authenticated-orcid":false,"given":"Paula","family":"Misiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Otolaryngology, Head and Neck Surgery, Wroc\u0142aw Medical University, Wroc\u0142aw, Poland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-1384","authenticated-orcid":false,"given":"Katarzyna","family":"Fleischer-Ste\u0328pniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Infectious Diseases and Hepatology, Wroclaw Medical University, Wroc\u0142aw, Poland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7624-631X","authenticated-orcid":false,"given":"\u0141ukasz","family":"Lewandowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Biochemistry and Immunochemistry, Wroclaw Medical University, Wroc\u0142aw, Poland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5652-4456","authenticated-orcid":false,"given":"Mateusz","family":"Bilski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of General and Pediatric Radiology, Wroc\u0142aw Medical University, Wroc\u0142aw, Poland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-485X","authenticated-orcid":false,"given":"Urszula","family":"Zaleska-Dorobisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of General and Pediatric Radiology, Wroc\u0142aw Medical University, Wroc\u0142aw, Poland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6250","published-online":{"date-parts":[[2024,12,31]]},"container-title":["Journal of Ultrasonography"],"original-title":[],"link":[{"URL":"https:\/\/jultrason.pl\/artykul.php?a=1258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T10:57:17Z","timestamp":1736765837000},"score":1,"resource":{"primary":{"URL":"https:\/\/jultrason.pl\/index.php\/issues\/volume-24-no-99-open-issue\/evaluation-of-liver-fibrosis-in-hcv-infected-patients-using-two-dimensional-shear-wave-elastography-2d-swe-before-and-after-antiviral-treatment#overlay"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,31]]},"references-count":0,"journal-issue":{"issue":"99","published-online":{"date-parts":[[2024,12,31]]},"published-print":{"date-parts":[[2024,12,31]]}},"URL":"https:\/\/doi.org\/10.15557\/jou.2024.0038","relation":{},"ISSN":["2084-8404","2451-070X"],"issn-type":[{"value":"2084-8404","type":"print"},{"value":"2451-070X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,31]]}}}