{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:06:28Z","timestamp":1744862788916,"version":"3.40.4"},"reference-count":0,"publisher":"Medical Communications Sp. z.o.o.","issue":"100","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Ultrason"],"published-print":{"date-parts":[[2025,4,4]]},"abstract":"<jats:p>Aim: Hypoplastic left heart syndrome is a  severe congenital heart defect that may be accompanied by\ntricuspid and mitral valve regurgitation. The aim of this paper is to identify a new ultrasound marker for\nevaluating the outcomes of fetuses with hypoplastic left heart syndrome. Material and methods: This was\na  single-center analysis of a  group of fetuses who underwent fetal ultrasound examinations at our tertiary center between 2016 and 2023. This study included 80 fetuses with hypoplastic left heart syndrome.\nThe gestational age of the studied fetuses ranged from 16.3 to 39.5 weeks. All anomalies and irregularities\naccompanying hypoplastic left heart syndrome were detected during the second and third trimesters of\npregnancy. Results: Among fetuses with hypoplastic left heart syndrome with tricuspid regurgitation, the\nmortality rate was 0% (0\/16) and the survival rate was 100% (16\/16). In contrast, in fetuses with hypoplastic\nleft heart syndrome with both tricuspid and mitral regurgitation, the mortality rate was 75% (3\/4) and the\nsurvival rate was 25% (1\/4). The incidence of death was significantly higher in the group of fetuses with\nhypoplastic left heart syndrome with both tricuspid and mitral regurgitation compared to the group with\ntricuspid regurgitation (Yates\u2019s chi-squared test: p = 0.003; Fisher\u2019s test: p = 0.0035). Conclusions: The coexistence of hypoplastic left heart syndrome with tricuspid and mitral regurgitation is significantly associated\nwith the death of newborns even when treatment and\/or surgery is performed. Therefore, the presence of\nmitral regurgitation in fetuses with hypoplastic left heart syndrome may serve as an additional ultrasound\nmarker for poor neonatal outcome.<\/jats:p>","DOI":"10.15557\/jou.2025.0009","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T07:35:01Z","timestamp":1744788901000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypoplastic left heart syndrome with mitral regurgitation: a new marker of poor fetal outcome"],"prefix":"10.15557","volume":"25","author":[{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital, Research Institute in Lodz, Poland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-0446","authenticated-orcid":false,"given":"S\u0142awomir","family":"Witkowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-2172","authenticated-orcid":false,"given":"Maria","family":"Respondek-Liberska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Medical Faculty, Ludwik Rydygier Collegium Medicum, Poland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3469-7064","authenticated-orcid":false,"given":"Iwona","family":"Strzelecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Diagnoses and Prevention of Fetal Malformations, Medical University of Lodz, Poland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6250","published-online":{"date-parts":[[2025,4,7]]},"container-title":["Journal Of Ultrasonography"],"original-title":[],"link":[{"URL":"https:\/\/jultrason.pl\/assets\/pdf\/artykuly\/jou-00086-2024-witkowski-pdf.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T07:35:02Z","timestamp":1744788902000},"score":1,"resource":{"primary":{"URL":"https:\/\/jultrason.pl\/index.php\/issues\/volume-25-no-100\/hypoplastic-left-heart-syndrome-with-mitral-regurgitation-a-new-marker-of-poor-fetal-outcome"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":0,"journal-issue":{"issue":"100","published-online":{"date-parts":[[2025,4,7]]},"published-print":{"date-parts":[[2025,4,4]]}},"URL":"https:\/\/doi.org\/10.15557\/jou.2025.0009","relation":{},"ISSN":["2084-8404","2451-070X"],"issn-type":[{"value":"2084-8404","type":"print"},{"value":"2451-070X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}