{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:10:59Z","timestamp":1790777459827,"version":"4.1.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Acta Veterinaria Hungarica"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>The complex interplay between <jats:italic>Mycoplasma synoviae<\/jats:italic> and chicken chondrocytes (CCH), which come into direct contact during infectious synovitis, has been examined at the level of gene expression. Our previous studies demonstrated a significant influence of <jats:italic>M. synoviae<\/jats:italic> on the level of CCH gene expression. Here, we show for the first time that <jats:italic>in vitro<\/jats:italic> co-cultivation of <jats:italic>M. synoviae<\/jats:italic> and CCH also induces upregulation of gene expression in this mycoplasma. We observed significantly increased expression of genes important for <jats:italic>M. synoviae<\/jats:italic> pathogenicity, including cysteine protease <jats:italic>cysP<\/jats:italic>, neuraminidase <jats:italic>nanH<\/jats:italic>, haemagglutinin <jats:italic>vlhA<\/jats:italic>, and the putative nuclease MS53_0284. Moreover, the pattern of gene expression was dependent on the infection environment. In CCH, significant changes in the expression of genes encoding catabolic enzymes of the cartilage extracellular matrix (cathepsins B, K and L, aggrecanase ADAM10, and matrix metalloproteinase MMP2) were demonstrated. Infection of CCH with <jats:italic>M. synoviae<\/jats:italic> also elevated the expression of the gene encoding peptidyl arginine deiminase, type III (PADI3), which is responsible for the post-translational citrullination of proteins.<\/jats:p>","DOI":"10.1556\/004.2016.003","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T17:21:08Z","timestamp":1456507268000},"page":"26-37","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.2","source":"Crossref","is-referenced-by-count":10,"title":["Mycoplasma and host interaction: In vitro gene expression modulation in Mycoplasma synoviae and infected chicken chondrocytes"],"prefix":"10.1556","volume":"64","author":[{"given":"Ivanka","family":"Cizelj","sequence":"first","affiliation":[{"name":"Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI-1230 Dom\u017eale, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daliborka","family":"Du\u0161ani\u0107","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI-1230 Dom\u017eale, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u0161an","family":"Ben\u010dina","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI-1230 Dom\u017eale, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojca","family":"Narat","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI-1230 Dom\u017eale, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Acta Veterinaria Hungarica"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/64\/1\/article-p26.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/004\/64\/1\/article-p26.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/004\/64\/1\/article-p26.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T20:53:33Z","timestamp":1686171213000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/004\/64\/1\/article-p26.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1556\/004.2016.003","relation":{},"ISSN":["0236-6290","1588-2705"],"issn-type":[{"value":"0236-6290","type":"print"},{"value":"1588-2705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]}}}